GENOA — Virgin Voyages sailings will be exclusively for passengers 18+, “which was a direct result of listening to future sailors and travel partners”, says the cruise line.Virgin Group Founder Sir Richard Branson and Virgin Voyages President and CEO Tom McAlpin hosted a ‘Ship Tease’ yesterday in Genoa at the keel laying ceremony for the first ship, scheduled to launch in 2020. The cruise line says it is now accepting US$500 refundable deposits for a pre-sale window at VirginVoyages.com.Live from Fincantieri’s shipyard, Sir Richard and Tom McAlpin arrived on stage via a 200-foot crane drop.“This is a very big day for Virgin Voyages, as an exciting new holiday option for travellers starts to get ship shape,” said Branson, adding: “She will be the most recognizable ship sailing the seven seas, delivering an irresistible sailor experience. We’re also committed to making sure our crew are the happiest at sea and will be proud to sail with us.”More news: War of words between Transat, Group Mach ramps upCEO McAlpin said the entire ship “will be built with an attention to detail, reflecting the craftsmanship and materiality inspired by super yachts.”Designed to feel more intimate and connected to the sea, 86% of all cabins will feature a sea terrace and 93% an ocean view, he said. “Virgin Voyages is creating a sophisticated ship and a transformational experience that offers our sailors a place where rejuvenating day-life meets exciting nightlife and everything in between.”Making first ship’s experience ‘Adult By Design’ was a decision driven by feedback “from future sailors and travel professionals, who are looking for a more elevated and premium experience, with a few Virgin style surprises.”The ship’s livery features a sleek silvery-grey hull with smoked glass and touches of Virgin’s signature red. Virgin Voyages’ first fleet will be known as the ‘Lady Ships’, a play on the term ‘your ladyship’, a nod to Virgin’s British heritage.McAlpin says the spirit of the ship will be represented by a mermaid design adorning the bow.More news: Marriott Int’l announces 5 new all-inclusive resorts in D.R. & MexicoConsistent with their commitment to have one of the cleanest fleets at sea, Virgin Voyages has also signed an agreement with Scanship, providers of advanced waste management systems. Travelweek Group Adults only for Virgin Voyages’ first ship, setting sail in 2020 Share Tags: Virgin Group Posted by Wednesday, November 1, 2017 << Previous PostNext Post >>
It’s been a rainy few days so far this week, and thoughts inevitably turn to grabbing a slice of sun on the continent. Our trio of tempting bargains this week all come in under the impressively low price of £54! Lanzarote from £42One place you’re virtually guaranteed to avoid the rain is the Canary Island of Lanzarote. The sunny year-round climate of this volcanic island is a permanent attraction to visitors, and there is something to suit everyone’s tastes along more than 200km of stunning Atlantic coastline. Find flights to LanzaroteNaples from £54The culinary attractions of the Neapolitan city are famous throughout the world, and extend far beyond simply pizza and pasta. The Campania region of Italy is also rich in art and culture and steeped in history, in addition to being located halfway between two major volcanic areas, the Phlegraean Fields, now a regional park, and Mount Vesuvius which is one of Italy’s three major active volcanoes. Find flights to NaplesToulouse from £50While this city in the southwest of France is most famous rugby and sausages, it has emerged as a major economic centre in the past 20 years thanks to major employers such as aviation industry leader Airbus. The city is now one of the wealthiest in France, and boasts an abundance of world-class restaurants, bars and cafés to explore, along with a pleasant May climate in the early 20C’s. Give it a go, at this price you’ve got nothing to lose! Find flights to ToulouseReturnOne wayMulti-cityFromAdd nearby airports ToAdd nearby airportsDepart14/08/2019Return21/08/2019Cabin Class & Travellers1 adult, EconomyDirect flights onlySearch flights Map RelatedLanzarote Focus: a closer look at the Island of FireThe small Canary Island of Lanzarote is best known as a sunshine holiday destinationIsland hopping in the Canary IslandsWhen most people visit the Canary Islands they visit only one, flying in and flying out from the very same airport. Perhaps they might gaze wistfully from the top of Teide on Tenerife or the peak of Pozo de las Nieves on Gran Canaria at the other islands beckoning across…Top 15 attractions and things to do in LanzaroteLooking for fun things to do in the sun in Lanzarote? Ok so the beaches are beautiful, but this Canary Island is a natural beauty full of volcanic vineyards, lava tunnels and other surprises. Here’s the top 15 things to see and do in Lanzarote that should definitely make it…
I sincerely hope you and all of yours have a fantastic holiday season. I’m very excited about 2015. If you haven’t seen my 25% guarantee, you’ll want to take a look at it. I’ve upped the ante here at Casey Research with this offer: if you don’t make at least 25% on this one stock by Thanksgiving of 2015 (November 26), you’ll get 100% of your money back—no questions asked. That’s a bold move, yes. I’ve personally put a lot of money on this one, and I think it’s a must-own stock for any serious speculator. Before I get started, on behalf of everyone at Casey Research, I’d like to wish all of you a happy holiday season. This is the last Casey Daily Dispatch of the year—it will return next Friday, January 2, with another thought-provoking subject from Paul Rosenberg. We thank you for reading and sharing these columns. Whenever some big news involving Russia or Putin hits the wires, I get media requests from around the world. This past week was exactly that, and one particular interview stood out in my mind. I was interviewed by someone I’ve never been interviewed by before—and David Knight did a fantastic job. He did his homework, hit me with some tough questions, and the end result is one of the best interviews I’ve done.
Recommended Link Justin’s note: Opportunities to make 50 times your money don’t come around often. But right now, one is staring us in the face. Today, we’re sharing a special essay from Casey Research founder Doug Casey. In it, Doug explains the rare opportunity shaping up in the gold market. As you’ll see, gold stocks could deliver historic gains in the years ahead…and now is the time to take advantage… By Doug Casey, founder, Casey Research My regular readers know why I believe the gold price is poised to move from its current level of around $1,250 per ounce to $1,500… $2,000… and eventually past $3,000. Right now, we are exiting the eye of the giant financial hurricane that we entered in 2007, and we’re going into its trailing edge. It’s going to be much more severe, different, and longer lasting than what we saw in 2008 and 2009. In a desperate attempt to stave off a day of financial reckoning during the 2008 financial crisis, global central banks began printing trillions of new currency units. The printing continues to this day. And it’s not just the Federal Reserve that’s doing it: it’s just the leader of the pack. The U.S., Japan, Europe, China… all major central banks are participating in the biggest increase in global monetary units in history. These reckless policies have produced not just billions, but trillions in malinvestment that will inevitably be liquidated. This will lead us to an economic disaster that will in many ways dwarf the Great Depression of 1929–1946. Paper currencies will fall apart, as they have many times throughout history. This isn’t some vague prediction about the future. It’s happening right now. The Canadian dollar has lost 33% of its value since 2013. The Australian dollar has lost 27% of its value during the same time. The Japanese yen and the euro have crashed in value. And the U.S. dollar is currently just the healthiest horse on its way to the glue factory. These moves show that we’re in the early stages of a currency crisis. But if you make the right moves, you could actually make windfall gains instead of suffering losses. Here’s how to do it… The huge winner during this crisis will be the only currency that has real value: gold. Gold has been used as money for thousands of years because it has a unique combination of qualities. Very briefly, it’s durable, easily divisible, convenient to carry, consistent around the world, and has value in and of itself. Just as important, governments can’t create gold out of thin air. It’s the only financial asset that’s not simultaneously someone else’s liability. When people wake up and realize that most banks and governments are bankrupt, they’ll flock to gold… just as they’ve done for centuries. Gold will rise multiples of its current value. I expect a 200% rise from current levels, at the minimum. There are many reasons, which we don’t have room to cover here, why gold could see a 400% or 500% gain. This should produce a corresponding bull market in gold stocks… perhaps of a magnitude we’ve never seen. A true mania for gold stocks could develop over the coming years. This could make anyone who buys gold stocks at their current depressed levels very rich. What History Teaches Us About Great Speculations Many of the best speculations have a political element to them. Governments are constantly creating distortions in the market, causing misallocations of capital. Whenever possible, the speculator tries to find out what these distortions are, because their consequences are predictable. They result in trends you can bet on. Because you can almost always count on the government to do the wrong thing, you can almost always safely bet against them. It’s as if the government were guaranteeing your success. The classic example, not just coincidentally, concerns gold. The U.S. government suppressed its price for decades while creating huge numbers of dollars before it exploded upward in 1971. Speculators who understood some basic economics positioned themselves accordingly. Over the next nine years, gold climbed more than 2,000% and many gold stocks climbed by more than 5,000%. The strategy that doesn’t work 99% of the time produces $2,100,000 A weird, newly revealed strategy could have made you $2.1 million DESPITE the fact that it doesn’t work on 99% of the stocks in the market. This strategy only works with a very, very small sub-niche of penny stocks, but it’s useless with blue chips, ETFs, dividend and tech stocks. However, within that small sub-niche, historical analysis shows this strategy would have a 95% accuracy rate and deliver average gains of 106%. Here’s the entire scoop on this unusual strategy, along with what specific sector of the market it profits from… Governments are constantly manipulating and distorting the monetary situation. Gold in particular, as the market’s alternative to government money, is always affected by that. So gold stocks are really a way to short government — or go long on government stupidity, as it were. The bad news is that governments act chaotically, spastically. The beast jerks to the tugs on its strings held by various puppeteers. But while it’s often hard to predict price movements in the short term, the long term is a near certainty. You can bet confidently on the end results of chronic government monetary stupidity. Mining stocks are extremely volatile for that very same reason. That’s good news, however, because volatility makes it possible, from time to time, to get not just doubles or triples but 10-baggers, 20-baggers, and even 100-to-1 shots. When gold starts moving higher, it’s going to direct a lot of attention towards gold stocks. When people get gold fever, they are not just driven by greed, they’re usually driven by fear as well, so you get both of the most powerful market motivators working for you at once. It’s a rare class of securities that can benefit from fear and greed at once. Remember that the Fed‘s pumping-up of the money supply ignited a huge bubble in tech stocks in the late ‘90s, and then an even more massive global bubble in real estate that burst in 2008. But they’re still creating tons of dollars. This will inevitably ignite other asset bubbles. Where? I can’t say for certain, but I say the odds are extremely high that as gold goes up, a lot of this funny money is going to pour into these gold stocks, which are not just a microcap area of the market but a nanocap area of the market. The combined market capitalization of the 10 biggest U.S.-listed gold stocks is less than 6% of the size of Facebook. I’ve said it before, and I’ll say it again: When the public gets the bit in its teeth and wants to buy gold stocks, it’s going to be like trying to siphon the contents of the Hoover Dam through a garden hose. Gold stocks, as a class, are going to be explosive. Now, you’ve got to remember that most of them are junk. Most will never, ever find an economical deposit. But it’s hopes and dreams that drive them, not reality, and even those without merit can still go up 10, 20, or 30 times your entry price. And companies that actually have the goods can go much higher than that. You buy gold, the metal, because you’re prudent. It’s for safety, liquidity, insurance. The gold stocks, even though they explore for or mine gold, are at the polar opposite of the investment spectrum; you buy them for their extreme volatility, and the chance they offer for spectacular gains. It’s rather paradoxical, actually. Why Gold Stocks Are an Ideal “Asymmetric Bet” Because these stocks have the potential to go 10, 50, or even 100 times your entry price, they offer something called “asymmetry.” You probably learned about symmetry in grade school. It’s when the parts of something have equal form and size. For example, cut a square in half and the two parts are symmetrical. Symmetry is attractive in some forms. The more symmetrical someone’s face is, the more physically attractive they are considered to be. Symmetry is often attractive in architecture. But when it comes to investing and speculating in the financial markets, the expert financial operator eschews symmetry. Symmetry is for suckers. The expert financial operator hunts for extreme asymmetry. An asymmetric bet is one where the potential upside of a position greatly exceeds its potential downside. If you risk $1 for the chance of making $20, you’re making an asymmetric bet. Amateur investors too often risk 100% of their money in the pursuit of a 10% return. These are horrible odds. But the financially and statistically illiterate take them. You might do better in a casino or most sports betting. It’s one of the key reasons most people struggle in the market. I’ve always been more attracted to asymmetric bets… where I stand a good chance of making 10, 50, even 100 times the amount I’m risking. I’m not interested in even bets. I’m only taking the field if my potential upside is much, much greater than my potential downside. Because of the extreme asymmetry gold stocks offer—because of their extreme upside potential when they’re cheap—you don’t have to take a big position in them to make a huge impact on your net worth. A modest investment of $25,000 right now could turn into $500,000 in five years. It has happened before and it will happen again. Right now gold stocks are near a historic low. I’m buying them aggressively. At this point, it’s possible that the shares of a quality exploration company or a quality development company (i.e., one that has found a deposit and is advancing it toward production) could still go down 10, 20, 30, or even 50 percent. But there’s an excellent chance that the same stock will go up by 10, 50, or even 100 times. I hate to use such hard-to-believe numbers, but that is the way this market works. When the coming resource bubble is ignited, the odds are excellent we’ll be laughing all the way to the bank in a few years. No one, including me, knows that the Mania Phase is just around the corner. But I’ve operated in this market for over 40 years. This is a very reasonable time to be buying these stocks. And it’s absolutely a good time to start educating yourself about them. There’s an excellent chance a truly massive bubble is going to be ignited in this area. If so, the returns are going to be historic. Regards, Doug Casey Founder, Casey Research Justin’s note: Casey Research’s resident gold stock specialist, Louis James, has just unveiled a proprietary strategy for selecting small gold stocks. Over a 30-year historical backtest, the strategy had a 95% success rate. Remarkably, the strategy even produced winning plays during gold’s $700 drop from 2011 to 2015. So, if the Mania Phase Doug predicts takes off, the asymmetrical gains you’ll see from these small gold stocks could hand you 10, 50, or even 100 times your money. Here, I explain the full story on Louis’ strategy so you can review it for yourself… — Ledbetter Lee’s 1906 penny stock secret Ledbetter Lee worked with the legendary Rockefeller family in the early 20th century, though he’s all but forgotten by history. Despite that, Ledbetter’s creation helps predict which tiny penny stocks will go up. In fact, historical analysis shows this little-used tool would have helped produce gains of 291%… 327%… 674%… 345%… and 236%. Here’s how… — Recommended Link
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Disabled people and other campaigners have reacted with shock, anger and concern to government proposals to consider forcing all sick and disabled people on out-of-work disability benefits to take part in “mandatory” activity.Disability News Service (DNS) revealed last week that the new work, health and disability green paper suggests that all claimants of employment and support allowance (ESA) with the highest support needs could be told to stay in regular touch with their local jobcentre, or risk having their benefits sanctioned.The green paper, Improving Lives, says ministers “could consider implementing a ‘keep-in-touch’ discussion with work coaches” for all people in the ESA support group, which “could provide an opportunity for work coaches to offer appropriate support tailored to the individual’s current circumstances” and “could be explored as a voluntary or mandatory requirement”.Paragraph 114 of the green paper goes on to say that such contact could use “digital and telephone channels in addition to face-to-face contact, depending on which was more appropriate for the individual and their circumstances”.Penny Mordaunt (pictured), minister for disabled people, appeared to confirm the proposal in the Commons this week, after she was asked about the future provision of employment advice for people in the support group.She told MPs the government was “consulting to establish if a ‘keep in touch’ discussion would be of benefit for this group, and if so, how and by whom should it be delivered, to ensure it meets the needs of individuals in this group”.Many disabled people reacted with horror to the story on the DNS website.Guy Stewart said: “Sanctions! Making us believe that our inability to gain work is our fault, when it absolutely is not, is cruel, but neatly fits into a government that constantly initiates dogma driven policy, rather then evidence driven policy.”“Sparkz_” said: “Will people have to phone from their hospital bed to keep in touch?”In response to Sparkz_, Jeffrey Davies said: “Been there done that, Atos at its best, in the high [dependency] unit. Ouch.”Rowan Farmer said: “I’m now wishing my life away, I’m 61 and thanks to the government I have another five years of stress and worry about assessments, appeals, benefits sanctions, poverty and homelessness, so much so that I’m actually looking forward to reaching 66 just to get rid of the added stress on top of several chronic, deteriorating and very painful illnesses!”Brian Mcardle added: “Now you know why [Theresa] May wants rid of the Human Rights Act.”Among those to comment on the story on Facebook was Erika Garratt, who encouraged other disabled people to take part in the consultation*.She said: “Filled in the form to tell them how ridiculous this idea is. We should all do this. “I am in the support group and this scares me so much.”Keith Evans, who is also in the ESA support group, said: “I’d rather jack ESA in than be forced to work that surely would kill me.”Beth Von Black replied to Evans: “That’s what they want. They want to scare us so much that we stop claiming what we’re entitled to!”She added later: “I’ve answered a few questions in the consultation and sent it off; angry that us long term disabled are being hounded into employment regardless of the fact that we cannot work!”There was also strong opposition to the proposal on Twitter.Professor Susan L Parish, professor of disability policy at Brandeis University in Massachusetts, in the United States, said: “This failed miserably in the #USA, so they’ll try it in the #UK.”Tracey Herrington said: “What a surprise – another unethical u turn. Who are they actually kidding when talking about personalised support… This is a direct attack.”Rick Meister tweeted: “Are the Tories about 2 sink 2 yet another low re chronically ill/disabled? Any such scheme must be voluntary… help, not threats!”Warren Belcher said: “This is so devastating, I can’t begin to think of the consequences and I’m dreading the impact this will have for so many people I care about.”And Hannah Smith tweeted: “How is this even ethical? Surely defeats the whole point [of] ESA in the first place.”Disability Rights UK (DR UK) said the green paper would “pave the way for success only if it leads to a complete overhaul” of the work capability assessment, one which produces “a system that encourages and supports people to try work where they feel they can, rather than threatening people with sanctions if they do not comply with (sometimes meaningless) activities”.It said the government would only be able to halve the disability employment gap if employers changed their behaviour, but it pointed to the green paper’s failure to announce any new incentives or requirements on employers, such as requiring the public sector to award contracts to companies with a good track record in employing disabled people, or providing a “comprehensive” helpline for small employers.It called for “more enforcement of the Equality Act in relation to those employers who simply continue to discriminate”, and said that the government’s strategy “will only work if employers are nudged and required to employ disabled people in greater numbers”.It welcome proposals such as expanding employment-related peer support, more tailored job support and work experience for young disabled people.But DR UK warned that research by the Employment Related Service Association (ERSA) suggested a cut in funding – in the move from the current Work Programme and Work Choice to the new Work and Health Programme – from £750 million in 2013-14 to less than £130 million in 2017-18.The ERSA research suggests this will lead to a drop in the number of disabled people accessing such support from 300,000 from 2012-15 to 160,000 from 2017-20.Although DR UK said it was “absolutely opposed” to plans to cut payments to new claimants in the ESA work-related activity group from next April, it said that investing all of the savings from this policy into employment support “could help strengthen the support offer to disabled people”.Philip Connolly, DR UK’s policy and development manager, said: “We have waited almost three years for this green paper and disabled people deserve a plan as ambitious as the government’s manifesto commitment [on halving the disability employment gap]; the green paper isn’t that plan.“The government’s response to its consultation on the green paper is the chance to really deliver on a plan.”Jonathan Bartley, co-leader of the Green party, and the father of a disabled son, was highly critical of the green paper.He said: “It is extremely concerning that the DWP is considering forcing ‘mandatory activity’ on all sick and disabled people.“It is barbaric to expect someone with a terminal illness, or who has no chance of getting better, to maintain contact with a ‘work coach’.“The Green party believes society should care for those who are most in need, not place damaging and unnecessary demands on them.“We call on the Labour party and the Lib Dems to join us in opposing these proposals.”A DWP spokesman repeatedly refused to clarify the meaning of paragraph 114, but said: “People in the support group have limited capability for work-related activity, but this does not mean that they should be left without any support at all.“And we want to hear views from as broad a range of disabled people, disability charities, and anyone else with something to contribute, on what more can be done to support this group.”*A consultation on the green paper will run until 17 February 2017, and among the ways to comment are via an online survey and by emailing firstname.lastname@example.org
WHEN Sydney Roosters come to town next month it will be a repeat of the first ever World Club Challenge match.Saints headed out on tour to Australia in 1976 to take on the Eastern Suburbs – who later became Saints opponents in this year’s World Club Series.The Saints of 1975-76 were dubbed ‘Dad’s Army’ because of a large portion of the squad was over 30-years-old, writes Alex Service.Experience is everything, however, and the team ended the campaign as Challenge Cup winners in the searing heat of Wembley Stadium and later beat First Division Champions Salford in the Premiership final.Captain Kel Coslett and the lads were really buzzing after their achievements and looked forward to a unique three-week tour Down Under to play a match against Queensland at Lang Park, Eastern Suburbs at the Sydney Cricket ground and finish off over in Auckland.Former Saints’ full-back Geoff Pimblett was, quite naturally delighted at the prospect of going to Australia and New Zealand.He says: “It was a fantastic experience for the lads, but it would have been better if we had say, just a week’s rest to recover from our own domestic matches and then jetted off Down Under.“But we had six weeks’ delay before the trip and we’d lost a bit of momentum by then – a great pity.”The party flew from Heathrow on June 17 to Brisbane with stops at Amsterdam, Vienna, Bahrain and Singapore. The first match was on June 22 at Lang Park, against a Queensland side which included some familiar names such as Greg Veivers, Ross Strudwick and John Lang.Despite holding a nine-point lead at one stage, Saints were a tired team when the Maroons clinched a 21-15 victory in the last few minutes.So on to Sydney and the unofficial World Club Championship match against Eastern Suburbs on June 29, coached by the famous Jack Gibson.Despite some early flurries, the Saints failed to make a real impression on the game and Easts, with the likes of Captain Artie Beetson earning the $5,000 dollar Man-of-the-Match award, were far too good on the night and won 25-2.The crowd numbered 26,856, including a large number of ex-pats, cheering on the visitors.“We had a few chances just before half-time, but we couldn’t take them,” recalls Geoff, “which was a great shame and they dominated after half-time.“We stayed at Bondi Junction and you remember daft things like ordering prawn cocktail for breakfast. It was all-inclusive and you could eat what you wanted, but we hadn’t seen things like that before.”Then it was on to Auckland and the slithering mud of Carlaw Park, before returning home on July 7.“We cut them [Auckland] up time and time again but couldn’t finish them off”, adds Geoff. “We ended up losing 20-13, but we’d had enough by then. If only we could have toured earlier – at our peak. Mind you, what memories, When you can sit in Bradman’s seat at the Sydney Cricket Ground – that’s what it is all about!”Saints will face Sydney Roosters at Langtree Park on Friday February 19 (8pm) as part of the prestigious World Club Series – and tickets are now on sale.They are priced at:Hattons Solicitors West Terrace, East Terrace and Family Stands:Adult – £22.50OAP and Young Adult – £15.50Junior – £10Solarking South and Totally Wicked North Stands:Gold: Adult – £30, OAP and Young Adult – £22.50, Junior – £12Silver: Adult – £28, OAP and Young Adult – £20.50, Junior – £12Bronze: Adult – £25, OAP and Young Adult – £18.50, Junior – £10Tickets can be bought by popping into the Ticket Office at Langtree Park, by calling 01744 455 052 or online here.A package for all three games (Leeds v North Queensland, Wigan v Brisbane) costs £60 and can be purchased by visiting www.rugbyleaguetickets.co.uk or calling the Rugby League Ticket Hotline on 0844 856 1113.
Once you’ve had your fill of food, retailers are ready and waiting for you to do some turkey-fueled shopping. Take a look at some of the tech deals that you can jump on next weekend.Related: Holiday 2018 Spending Could Reach $1 TrillionAmazonAn Echo Spot for $89.99The new Echo Show for $179.99A Sony RX100 V camera for $892A Samsung Galaxy S9 64GB phone for $644.35WalmartA PS4 console with the new Spiderman game included for $199A Samsung 11.6-inch Chromebook 3 for $99.99A Samsung 50 inch Class 4K (2160P) UHD Smart LED TV for $327.99A Google Home Hub for $149Best BuyAn LG 60 inch Class LED UK6090 Series 2160p Smart 4K UHD TV with HDR for $549.99A Dell Inspiron 2-in-1 13.3 inch Touch-Screen Laptop for $699.99A 64GB Apple 10.5-Inch iPad Pro with Wi-Fi for $649.99AppleA refurbished HomePod for $299Office DepotAn HP 15-db0051od Laptop for $399An Epson WorkForce Pro WF-4740 Wireless All-In-One Printer, Copier, Scanner, Fax for $199.99A Dell 27 inch HD LCD Monitor for $119.99Logitech Z150 2-Piece Speakers for $14.99StaplesA VARO Portable WiFi + Bluetooth Multi-Room Speaker for $19.99A Seagate STDR5000102 5TB USB 3.0 Back Up Plus Portable Drive for $199.99A NETGEAR Arlo Smart Home Security Camera System for $119.99 1 min read Staff Writer. Covers leadership, media, technology and culture. Add to Queue Stock up on some new gadgets at a discount. Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals November 15, 2018 Entrepreneur Staff Black Friday –shares Here Are the Best Black Friday Tech Deals Image credit: mar1koff | Getty Images Next Article Nina Zipkin Register Now »
Source:https://www.augusta.edu/mcg/ Reviewed by James Ives, M.Psych. (Editor)Nov 28 2018A lipid that helps keep skin cell turnover on track may help restore healthy turnover in psoriasis, investigators say.Topical application of the lipid phosphatidylglycerol, or PG, on a mouse model of psoriasis reduced inflammation as well as characteristic, raised skin lesions, they report in the Journal of Investigative Dermatology.They had already shown that PG has a role in both regulating the function of the major cell type in our skin called keratinocytes and suppressing skin inflammation.Now they have the first evidence that PG inhibits toll-like receptor activation by the antimicrobial peptides produced by those skin cells, says Dr. Wendy B. Bollag, cell physiologist in the Department of Physiology at the Medical College of Georgia at Augusta University.Toll-like receptors are a family of receptors that detect external invaders as well as internal damage signals then activate an immune response. Our skin is our largest organ and front line of defense, and a variety of skin cell types make antimicrobial peptides, which function like an endogenous antibiotic to help the skin protect us.The common skin condition psoriasis upsets the works by increasing both the production of skin cells and production of these antimicrobials by those cells.In some patients it may be a problematic immune system that initiates the vicious cycle of skin cells producing proteins called cytokines that call in more immune cells that make more cytokines that cause skin cells to make even more cytokines and excessively proliferate, says Bollag. In others, the antimicrobials may initiate the vicious cycle.Either way, more antimicrobials get produced which is probably beneficial since psoriasis also impairs the skin’s ability to prevent invaders.But these high levels of antimicrobials also produce an inflammatory response much like an invader’s might, resulting in the red, flaky patches that typically surface on high-touch areas like the elbows, forearms and knees and also show up on the scalp and elsewhere, says Bollag, the study’s corresponding author.Because at higher levels, the body sees these protective antimicrobial peptides as danger-associated molecular patterns, or DAMPS, which, as the name indicates, it views as signs of danger. DAMPS then activate toll-like receptors.It’s the increased and chronic level in psoriasis that heightens the awareness and response, says first author Dr. Vivek Choudhary, molecular biologist and physiologist in the MCG Department of Physiology.Once toll-like receptors get activated, the immune system makes proinflammatory cytokines that bring in T cells, which help drive the immune system attacks.”It’s actually T cells that help maintain the disease,” Bollag says, “But we are thinking that the innate immune system is sort of what initiates it,” she says of that toll-like receptor activation.In the continuing vicious cycle, all the immune action prompts the skin cells to actually make more antimicrobials in response to the perceived danger. “It’s a natural system that has kind of gone haywire,” she says.The investigators used S100A9 as their representative antimicrobial. In psoriasis, the levels of S100A9 correlate with the severity of the disease and, when treatment works, blood levels of S100A9 decrease.Related StoriesArtificial intelligence better than humans in diagnosing pigmented skin lesionsScientists discover how resistance to the chemotherapy drug 5-fluorouracil arisesHair loss could soon be a thing of the past, say researchersThey found that both in keratinocytes as well as inflammation-promoting immune cells called macrophages, PG suppressed activation of toll-like receptors by DAMPS, in this case S100A9.Next steps include finding a version of PG that can more easily permeate the skin since the larger lipid is a bit too big to easily pass through the natural barrier. Interestingly, psoriasis hinders the barrier function so PG can initially get through, but when the condition improves, PG’s access deteriorates, the investigators note.They suspect PG’s inhibition of toll-like receptors doesn’t just happen in psoriasis, but that constant fine tuning of the immune response is among its usual functions.”You want to be able to dial it up, but not go overboard,” Bollag says. “We think that may be part of the job of PG, to basically keep the immune system from going from zero to 60 in one second flat.”This is particularly important in body areas regularly exposed to the elements like the skin, lungs and gastrointestinal tract, she says. Maybe part of the problem with psoriasis is that this fine control no longer works well, she says.Inflammation in the absence of an infection is a hallmark of psoriasis. The resulting inflammation produces a “feed forward” response: Keratinocytes start to excessively proliferate and abnormally differentiate and the skin thickens.PG enables the normal differentiation of new skin cells as cells make their way up multiple layers, reach the surface and old cells slough off.PG is made from glycerin, a natural alcohol, water attractor and key component of many lipids, which helps skin look better and aids this healthy production and maturation of high-turnover skin cells. Glycerin is transported by aquaporin-3, which the MCG investigators believe is decreased in psoriasis versus healthy skin.Today there are a variety of topical treatments for psoriasis, including vitamin D analogues and glucocorticoids, but nothing that works great for all patients, Bollag says. Part of the problem likely is that psoriasis causes vary and the reality that they are mostly not understood. Systemic drugs also are given that generally suppress the immune response, which have obvious side effects like leaving patients susceptible to infection and cancer.Bollag doesn’t think PG will be a magic bullet either, but may one day be a good option for patients with mild disease or as an adjunct to other therapies.PG is also a component of surfactant, which enables the airs sacs in the lungs to properly inflate so we can breathe. It’s been shown to inhibit inflammation in the lungs induced by microorganisms and that it works there as well through toll-like receptors. Bollag notes these new findings about what happens in the skin are likely applicable to similar conditions, where this so-called “sterile inflammation” occurs in response to substances naturally found in the body.
Source:https://news.iu.edu/stories/2018/12/iupui/releases/03-hoosier-firefighters-cancer-cardiovascular-mortality.html Reviewed by Kate Anderton, B.Sc. (Editor)Dec 3 2018Hoosier firefighters face a significantly higher risk of dying from cancer than non-firefighters in Indiana, according to a study that shows death from malignant cancers was the leading cause of death for Indiana firefighters between 1985 and 2013.Of 2,818 Indiana firefighters who died between 1985 and 2013, 30.4 percent died from malignant cancers. The study found the firefighters experienced an estimated 20 percent increase in the odds of dying due to malignant cancers compared to non-firefighters.This study is unique in that it is one of the first to match an exposed firefighter population to an independent comparison group of non-firefighters from a general population.Related StoriesResearchers identify potential drug target for multiple cancer typesAdding immunotherapy after initial treatment improves survival in metastatic NSCLC patientsLiving with advanced breast cancerThe research findings are in the paper “Excess mortality among Indiana firefighters, 1985-2013,” which was published in the American Journal of Industrial Medicine.”The purpose of this study was to examine patterns of chronic disease deaths among Indiana firefighters from 1985 to 2013 compared to non-firefighters,” said Carolyn Muegge, a doctoral candidate in the Richard M. Fairbanks School of Public Health at IUPUI, who is also a research scientist at the National Institute for Public Safety Health in Indianapolis and first author on the paper.”Firefighters are exposed to toxic agents, increasing their risk for cancer and cardiovascular disease,” Muegge said. “We examined the odds of cancer and cardiovascular mortality of firefighters relative to a matched group of non-firefighters from the general population.”To compare firefighters and non-firefighters, each firefighter death record was matched to four non-firefighter death records by age at time of death, sex, race, ethnicity and year of death.Heart disease was the second leading cause of firefighters’ deaths, accounting for 824, or 29.2 percent, of the deaths. There was no difference in the odds of death due to cardiovascular diseases between firefighters and non-firefighters.When the causes of deaths of firefighters between 1983 and 2013 are looked at in five-year increments, research shows heart disease had been the leading cause of Indiana firefighters’ deaths until 1995, when “the burden of cancer significantly surpassed heart disease,” the paper stated.Heart disease was the leading cause of death in the non-firefighter comparison group, at 29.6 percent, followed by malignant cancers at 27.1 percent.According to the researchers, the leading cause of firefighter deaths — cancer and heart disease — underscore the need for implementing and expanding cancer and heart disease risk factor reduction programs and policies for firefighters.
Source:http://www.asrc.cuny.edu/ Reviewed by James Ives, M.Psych. (Editor)Apr 12 2019A newly published paper in the Lancet journal EBioMedicine identifies a link between high levels of blood lipids and worsening of disease in multiple sclerosis (MS) patients who are overweight or obese.The longitudinal investigation, conducted by researchers at the Advanced Science Research Center(ASRC) at The Graduate Center of The City University of New York’s Neuroscience Initiative in collaboration with clinicians at the Icahn School of Medicine at Mount Sinai, followed recently diagnosed MS patients for two years. The researchers found that individuals who were overweight or obese had higher levels of blood lipids called ceramides, which placed markers on the DNA of monocytes, making them proliferate. Monocytes are blood cells that can travel to the brain and damage nerve fibers, and two years into their diagnosis, study participants with higher levels of ceramides and monocytes also had greater loss of motor skills and more brain injury.”Our study identifies important correlations between ceramide levels, body mass index, and disease progression in MS patients,” said ASRC Neuroscience Initiative Director Patrizia Casaccia, a professor at The Graduate Center. “We found that overweight and obese individuals with MS have higher ceramide levels than people with the disease who are not overweight and also than individuals who are overweight or obese but otherwise in healthy conditions. This is important because we and others had previously identified ceramides in the cerebro-spinal fluid surrounding the brain of MS patients, and we attributed their increased abundance to the body’s efforts to recycle the damaged myelin. In this study, however, we also detect higher ceramide levels in the blood of overweight and obese MS patients than we did in patients with normal body mass index, suggesting that overabundant lipids can be derived not only from damaged brain cells, but also from excessive dietary intake of saturated fats.”MethodologyTwo cohorts of patients — a primary one and a validation group — were recruited from the Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Mount Sinai and the National Institutes of Health to participate in the study. For the first group, 54 therapy-naïve MS patients 18 to 60 years old with high or normal body mass indexes (BMIs) were evaluated using brain MRI to identify signs of brain damage; a clinical assessment to ascertain weight, disabilities and other vital information; and blood tests to analyze the types of circulating lipids and white blood cells. An independent validation group of 91 MS patients from the National Institute of Health with the same characteristics and additional control cohorts of healthy individuals within the same BMI range were similarly evaluated.Related StoriesResearchers move closer to finding the root cause of MSStudy investigates the influence of surgery, anesthesia on MS relapse riskMice study suggests potential treatment approach for MS in humansResearchers found that MS patients with high BMIs had higher ceramide levels and more circulating monocytes than were evident in healthy individuals with the same BMIs. High-BMI MS patients showed worsening disability and more brain lesions at the MRI compared to their normal BMI counterparts. The researchers went on to find that ceramides can enter inside immune cells called monocytes and change the way these cells read the genetic information encoded in the DNA. These epigenetic changes were also found in monocytes circulating in the blood of MS patients with high BMI.SignificanceThe detection of ceramides inside the nucleus of blood cells and the ability of these lipids to induce epigenetic changes suggests that saturated fatty acids may have long-lasting functional effects, which over time steer the MS disease course towards worsening disability. In short, bad dietary habits may have negative consequences in healthy subjects, but they have an even more pronounced deleterious effect on patients with MS because the degrading myelin can accumulate and further increase ceramide levels.”This study gives us a much-needed view into the environmental influences that can affect and change the behavior of cells in an individual’s body,” said Kamilah Castro, the paper’s first author and a graduate student in professor Casaccia’s lab. “Our findings suggest that increased levels of saturated fat as a result of dietary habits are one likely cause of the epigenetic changes that advance MS, which gives us a starting point for a potential intervention.”The researchers’ findings support the concept of nutri-epigenomics (the ability of food to modify the way genomic information is interpreted by each cell) and the idea that lifestyle factors such as diet and weight can function as disease modifiers. Additional studies on larger cohorts are needed to validate the current findings. Further investigation is also needed to determine whether specific dietary interventions and weight management could be useful in helping MS patients manage and slow the progression of their disease and better respond to disease-modifying treatments.”This translational study is exciting from a clinical perspective as it sheds light on a potentially important mechanism that can help explain our clinical observations regarding obesity and MS prognosis,” said Ilana Katz Sand, associate medical director of the Corinne Goldsmith Dickinson Center for MS at Mount Sinai. “We look forward to continuing to work on this important topic through future clinical studies to evaluate the impact of weight management and dietary intervention in MS.”
Reviewed by Alina Shrourou, B.Sc. (Editor)Apr 22 2019Scientists from Far Eastern Federal University (FEFU) in cooperation with colleagues from Blokhin Russian Cancer Research Center (Moscow), Switzerland, and Sweden for the first time studied proteins, which constitute WNT signaling pathway of the cancer stem cells of glioblastoma multiforme (GBM CD133+ CSCs), one of the most aggressive brain tumors. Researchers revealed a number of proteins, which are potential targets to attack during complex antitumor therapy. A related article was published in Oncology Reports.Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors that is extremely resistant to therapy. On average, patients with such diagnosis live for 15 months. Only 27% of patients live more than two years following the diagnosis. According to scientists, tumor resistance to treatment is associated with cancer stem cells, and, in particular, with the activation of WNT signaling pathways in them.WNT signaling pathways in human cells are responsible for a number of essential functions, including cell proliferation, i.e. their reproduction, and the ability to differentiate into other types of cells. Unfortunately, they can contribute to the proliferation of cancer cells.”The behavior of the stem cells of glioblastoma multiforme is an urgent spot calling for research in modern medicine. Irradiation, cytostatics, and contemporary targeted chemotherapy are almost ineffective against cancer stem cells. Our idea is to use radiation simultaneously with drugs that suppress DNA retrieval process in cancer cells, followed by aggressive chemotherapy, one of the strategic objectives of which is to attack cancer stem cells.” said Igor Bryukhovetskiy, the author of the research idea, the Director of the Department of Fundamental Medicine in the FEFU School of Biomedicine.Related StoriesHow cell-free DNA can be targeted to prevent spread of tumorsUsing machine learning algorithm to accurately diagnose breast cancerNew study to ease plight of patients with advanced cancerThe scientist emphasized that he and his colleagues for the first time have managed to study proteins that form the WNT signaling pathway and directly interact with its components in human CD133 + stem cells of glioblastoma multiforme. The researchers found out that the set of proteins (proteome) in glioblastoma stem cells differs fundamentally from the one in other types of tumor cells. Scientists have also recognized other potential targets, the massive suppression of which can lead to a significant improvement of complex antitumor therapy outcome. These important results need further refinement during new in-depth research.How to affect the glioblastoma cancer stem cells is a conundrum far from a trivial. To crack one has engaged the world best laboratories.”In our research, we proceed from the fact we have proved previously: cancer stem cells execute their full potential when building up a bloodstream of a tumor, significantly accelerating its growth rate. Suppression of WNT-signaling proteins will allow increasing the effectiveness of anti-angiogenic therapy, i.e. treatment directed against the formation of new microvessels based on the vascular network already existing in the tissue. Such therapy is an integral part of the modern protocol for the comprehensive treatment of glioblastoma. The results of our studies can be brought into clinical practice in the near future.” summed up Igor Bryukhovetsky. Source:https://www.dvfu.ru/en/
A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) R. Esfandyarpour, A. Kashi, M. Nemat-Gorgani, J. Wilhelmy, R. W. Davis Proceedings of the National Academy of Sciences Apr 2019, 201901274; DOI: 10.1073/pnas.1901274116 https://www.pnas.org/content/early/2019/04/24/1901274116 Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome F Ciregia, L Kollipara, L Giusti, R P Zahedi, C Giacomelli, M R Mazzoni, G Giannaccini, P Scarpellini, A Urbani, A Sickmann, A Lucacchini & L Bazzichi Translational Psychiatry volume 6, page e904 (2016) https://www.nature.com/articles/tp2016184 Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics Dorottya Nagy-Szakal, Dinesh K. Barupal, Bohyun Lee, Xiaoyu Che, Brent L. Williams, Ellie J. R. Kahn, Joy E. Ukaigwe, Lucinda Bateman, Nancy G. Klimas, Anthony L. Komaroff, Susan Levine, Jose G. Montoya, Daniel L. Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn & W. Ian Lipkin Scientific Reportsvolume 8, Article number: 10056 (2018) https://www.nature.com/articles/s41598-018-28477-9 Ron Davis is the senior author of a paper that describes a blood test that may be able to identify chronic fatigue syndrome. Image Credit: Steve Fisch By Dr. Ananya Mandal, MDApr 29 2019People suffering from chronic fatigue syndrome (CFS) have been up until now treated with scepticism at best. Their symptoms have been negated as vague and their debilitating condition has not received the status of being proven in a test. No more now!Researchers from Stanford University School of Medicine have devised a blood based test that can accurately identify blood biomarkers that determine that a person is suffering from this condition. This provides a scientific proof that the disease does exist.Lead author and researcher Ron Davis, a professor of biochemistry and of genetics said in a statement, “Too often, this disease is categorized as imaginary.” On visits to the doctor the patient is usually prescribed a battery of tests for the liver, kidney and heart, blood and immune cells. He explained, “All these different tests would normally guide the doctor toward one illness or another, but for chronic fatigue syndrome patients, the results all come back normal.” In their endeavours, Davis and Rahim Esfandyarpour, a former Stanford research associate and now faculty at University of California-Irvine, along with others have devised a blood based test to detect CFS. The test basically looks at the response of the immune cells to stress. The team in their pilot study took blood samples of 40 people. Of these 20 were diagnosed to be suffering from CFS based on their symptoms. The tests results could accurately pinpoint all the cases of CFS and did not make a diagnosis in any of the healthy persons.The researchers hope that this test could soon be modified and studied in depth to develop drugs to treat the condition as well. The team is using similar principles to look for drugs that could potentially help people with this condition. The study titled “A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS),” described the study findings and the results were published in the journal Proceedings of National Academy of Sciences.DiagnosisTypically CFS is diagnosed on the basis of symptoms. There is extreme exhaustion, unexplained pain, sensitivity to light, fever, irritable bowel syndrome, lymph node swelling, sleep problems, problems of cognition etc. the problems are seen in the gastrointestinal system, immune system, hormone system, heart and the brain. All other disease conditions need to be ruled out before CFS is formally diagnosed. CFS is also called myalgic encephalomyelitis and can be called ME/CFS. In the United States alone there are over 2 million people who are diagnosed with CFS says Davis. Davis says that his own son suffers from the condition for over a decade and their study was an effort to help people like his son.For their test the team used a “nanoelectronic assay.” When the healthy plasma cells and immune cells are subjected to stress, there are minimal changes in energy. The devise sends in thousands of tiny currents into the plasma samples causing the immune cells to respond and react. The reactions of cells from CFS patients are different from those of healthy persons. The device is accurate enough to pick up these nano-signals and correlate it with the health of the sample. The bigger the electrical signals sent out from the cells – more is the change at a cellular level explain the researchers. They add that this means that the cells are “flailing” under stress and are not able to process the stress adequately. The spikes were clearly seen in the results of the samples from CFS patients compared to those from healthy controls. The team used “supervised machine learning algorithms” or artificial intelligence technology to rapidly detect these spikes. This made the test reliable as well as accurate.Related StoriesIntermittent fasting shown to improve blood glucose levelsNovel technique that uses nanotechnology and photonics prevents bacterial infections on surgical implantsRadiometer’s ABL9 blood gas analyzer awarded Red Dot Design AwardDavis said, “We don’t know exactly why the cells and plasma are acting this way, or even what they’re doing. But there is scientific evidence that this disease is not a fabrication of a patient’s mind. We clearly see a difference in the way healthy and chronic fatigue syndrome immune cells process stress.” The team is now recruiting more number of patients to expand their pilot study and to see if it works in large populations accurately.Esfandyarpour said, “Using the nanoelectronics assay, we can add controlled doses of many different potentially therapeutic drugs to the patient’s blood samples and run the diagnostic test again.” Thus he explained how they could use their nanotechnology based test to also screen for potential drugs to treat CFS. If the drugs worked, then they probably would reduce the spikes on the test he said. At present they have found a drug that could help restore healthy functions of the immune cells and the plasma. They hope that soon the drug could be tried on human patients in clinical trials wherein its benefits could be proved. The drug in question currently is approved by the Food and Drug Administration (FDA), they add.The study received funds from the Open Medicine Foundation.Bottom-up proteomicsA few years back researchers F. Ciregia and colleagues from University of Pisa, Leibniz-Institut für Analytische Wissenschaften, Germany, Università Cattolica, Rome, University of Aberdeen, IRCCS-Fondazione Santa Lucia, Rome and more collaborated to find mitochondrial changes that could help detect CFS.Their study titled, “Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome,” was published in the journal Translational Psychiatry back in 2016.The team looked at the cellular structures of a pair of twins’ saliva samples. They studied their mitochondrial proteins. Using “Nano-liquid chromatography electrospray ionization mass spectrometry (nano-LC-MS)” they studied the mitochondria that came from the platelets of the blood samples of the twins. They selected 3 proteins from the samples and correlated it with saliva samples from 45 healthy controls and 45 patients with CFS. The three proteins were “aconitate hydratase (ACON), ATP synthase subunit beta (ATPB) and malate dehydrogenase (MDHM)”.Results revealed that there was a rise in the ATPB and ACON proteins in patients with CFS. Authors conclude, “these results suggest that our potential markers could be one of the criteria to be taken into account for helping in diagnosis.” They also hoped that this test would help develop tailored treatments for patients with CFS.Metabolomic biomarkersIn a more recent study by Dorottya Nagy-Szakal from Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York and colleagues studied markers for CFS. Their study titled “Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics,” was published in July 2018 in the journal Nature Scientific Reports.The team discovered biomarkers from plasma as well as stool that could help detect CFS. They included 50 CFS patients and 50 healthy controls in their study. Their study showed that there was altered levels of “choline, carnitine and complex lipid metabolites.” Patients with CFS tended to have raised levels of plasma ceramide, they wrote.The authors hoped that from their study diagnostic tests could be devised for patients with CFS by detection of these biomarkers from stool and plasma samples and in future treatments could be strategized as well.References
BP faces total costs of around $65 billion, including fines and compensation, from the Gulf of Mexico oil spill disaster in 2010. © 2018 AFP And BP said in a statement it also expects to be hit by an additional $3.0 billion of Gulf-related costs this year, up from a previous estimate of $2.0 billion.This brings BP’s total cost linked to the disaster—including fines and compensation to businesses—to around $65 billion at the end of 2017.”With the claims… work very nearly done, we now have better visibility into the remaining liability,” BP chief financial officer Brian Gilvary said in a statement. “The charge we are taking as a result is fully manageable within our existing financial framework, especially now that we have the company back into balance” on higher oil prices, he added.Following the announcement, BP’s share price traded down 1.7 percent at 523.6 pence on London’s FTSE 100 index, which was flat overall in morning deals.BP saw its fortunes and reputation ravaged by the devastating oil spill disaster eight years ago caused by an explosion at the Deepwater Horizon drilling rig that the company leased.The blast killed 11 men off the coast of Louisiana and caused 134 million gallons (507 million litres) of oil to spew into Gulf waters, sparking the worst environmental catastrophe in US history. BP says oil spill compensation fund running out Explore further British energy giant BP said Tuesday it will take an additional charge of $1.7 billion (1.4 billion euros) in the fourth quarter of 2017 linked to the Gulf of Mexico oil spill disaster in 2010. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: BP hit by new $1.7bn Gulf oil spill charge (2018, January 16) retrieved 18 July 2019 from https://phys.org/news/2018-01-bp-17bn-gulf-oil.html
Explore further Citation: Airline technology supplier says outage has been fixed (2019, May 14) retrieved 17 July 2019 from https://phys.org/news/2019-05-airline-technology-supplier-outage.html Travel-technology provider Sabre says the problem that prevented some airline travelers from checking in for flights has been fixed. A Sabre spokeswoman said Tuesday that the problem originated with one of the company’s network suppliers, CenturyLink.Cassidy Smith of Sabre says the glitch affected airlines that connect with Sabre through CenturyLink’s network.Smith declined to identify the affected airlines. Some JetBlue customers complained they were unable to check in for flights.CenturyLink did not immediately respond to phone and email messages seeking comment.FlightStats says about 1,900 U.S. flights were delayed by early afternoon on the East Coast, although it’s unclear how many are related to the Sabre failure.Sabre suffered a similar outage that affected several U.S. airlines on April 29. © 2019 The Associated Press. All rights reserved. Several US airlines hit by brief computer-related outage This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.