Joe Huizenga Both these teams have had devastatin

first_imgJoe HuizengaBoth these teams have had devastating injuries this year. Ryan Lindley’s had the bulk of two games as starting QB under center now…they haven’t been pretty but I just have a hunch it finally comes together a bit more this week for the Cardinals.Basically, the Jets are a bigger mess…smile Cardinal fans, smile.Final Score: Cardinals 27, Jets 26 Top Stories John GambadoroDo they have to play? Can’t take the Cardinals on the road and bringing with them a pathetic 7-game losing streak, even against an inept Jets team. New York, embarrassed by New England on Thanksgiving Day, got a few extra days to get healthy and prepare for Arizona and that should be enough to squeak out a victory. Arizona will play hard; they haven’t quit on Ken Whisenhunt yet, but the lack of a quarterback is just killing them. I look for Lindley to improve some and a heavy dose of Beanie Wells. But this game comes down to who makes more mistakes not who makes more big plays, and that unfortunately is the Cardinals.Final Score: Jets 20, Cardinals 17 Katy HartleySo Lindley is starting and the Cards have lost their center… Looks to be another underwhelming performance by the offense… The defense might be able to keep it close, but typically the Cards struggle on the East coast – I think Jets have the edge with home field advantage.Final Score: Jets 24, Cardinals 17 0 Comments   Share   Dave BurnsTwo teams who win about as often as I hit the gym meet up on Sunday. Hard to pick a winner in this bunch. The Jets’ issues have been magnified because they’re the Jets, but they have the better QB, they’re at home, it’s a long trip for a Cardinals team that is riding a two month losing streak, and the Jets have the benefit of extra time to prepare. As bad as they are, there are more reasons to pick the Jets than the Cards.Final Score: Jets 20, Cardinals 17 The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo Adam GreenCardinals/Jets is the type of matchup dreams are made of.Horrible, horrible dreams.The Jets might be the only team in the NFL with a worse quarterback situation than the Cardinals, though any difference is pretty negligible. Mark Sanchez isn’t great, but he has some ability — we can’t for sure say the same for Ryan Lindley.This game will not be pretty.Final Score: Jets 20, Cardinals 13 Derrick Hall satisfied with D-backs’ buying and selling Carter NackeSunday is going to be ugly. The Jets have been struggling almost as bad as the Cardinals, and Sunday is going to be a toss-up. However, I’m predicting the upset. Cards D is going to come up big and a last-second Feely FG will seal the.Final Score: Cardinals 16, Jets 13 The Arizona Cardinals are 4-7. The New York Jets are 4-7.Someone has to win — or, rather, someone has to not-lose. Can the Cardinals end their losing streak in the Big Apple? The experts from ArizonaSports620 tell you what they think.Share your own prediction with a comment. Former Cardinals kicker Phil Dawson retires Vince MarottaThey’re still playing this game? OK, just kidding. Two 4-7 teams headed in the wrong direction, and there’s some speculation that the losing coach will also lose their job. Unlike the Jets, the Cardinals have been mostly competitive during their seven-game losing streak. Rex Ryan’s team has been blown out by an average of 24 points in their last three losses — including the Thanksgiving night debacle at the hands of the Patriots. Seriously, I laughed about Mark Sanchez’s butt sack and fumble for about 30 solid minutes. But going on the road to the East coast to play an early game is never easy, especially when you’re facing a team that’s a little more rested. If the Jets can overcome their heavy hearts in the wake of Fireman Ed stepping down as the most annoying fan, I mean, the unofficial team mascot, they’ll win.Final Score: Jets 20, Cardinals 17 James MelloThe Cardinals are better in every phase of the game at this point in the season. There are very few teams the Cardinals could say that about offensively, but the Jets are one of them. Offensively the Cards still have more talent because of a lack of receiving threats for the Jets. The Cardinals’ main goal offensively will be to just not lose the game. The defense of the Cards will be able to create problems early and often against the Jets. If they were able to intercept Matt Ryan five times, Mark Sanchez should be no issue. Arizona is better on special teams as well, which was shown by the consistent blunders on Thanksgiving by the Jets against New England. Low scoring game but Arizona wins.Final Score: Cardinals 14, Jets 10 Charlie FeinermanFinally, the Cardinals will end the losing streak. Ryan Lindley has a big game, showing his full potential with at least 250 yards, 3 touchdown passes and one interception. The Jets (unless it becomes Tebow Time) will gain a total of 150 yards against the Cardinals defense. Patrick Peterson finally get a punt return touchdown.Final Score: Cardinals 24, Jets 3 Grace expects Greinke trade to have emotional impact Dave DulbergThe Jets are 2-4 at home this season, with their four losses coming by an average of 22.7 points per game. The Cardinals are the first NFL team in history to a season 4-0 only to lose their next seven games. The scheduling gods have made it so that one of those awful statistics has to come to a screeching halt on Sunday. Unfortunately for Cardinals fans, brace yourself for loss No. 8. When Mark Sanchez is the more competent starting quarterback, you know you’re in for a long day. Ryan Lindley won’t throw four INTs this week, but he’ll turn the ball over just enough to keep Arizona from competing late.Final Score: Jets 24, Cardinals 14last_img read more

December 14 2003 QUADERNI Four notebooks written

first_imgDecember 14, 2003QUADERNI: Four notebooks written by Soleri have been published and are now available for sale in the Galleries at Arcosanti and Cosanti. These notebooks are part of the Quaderni, a series that will include writings on 126 topics when complete. All topics are summarized in the first Quaderno.[Photo: AA & Text: KH] Jewel Blackfeather, Book Initiatives Coordinator, and Selvam Rajamani, Graphic Designer, have been working to prepare the text and images for publication. The topics available now include Earthcasting, Ecominutiae and Eros.[Photo: AA & Text: KH]last_img

Rep Markkanen invites residents to meet and greets

first_img24Jun Rep. Markkanen invites residents to meet and greets Sunday, June 30th2 p.m. EDT at the Wakefield VFW, 107 US-2 in Wakefield;4:30 p.m. EDT at Twilly’s Restaurant, 13909 US-45 in Bruce Crossing; and6:45 p.m. EDT in the Blue Line Room at the Student Development Complex of Michigan Tech University, 1400 Townsend Drive in Houghton. Categories: Markkanen News             Rep. Greg Markkanen of Houghton announced he will be hosting four meet and greets for residents in the 110th district on Sunday, June 30 and will be joined by State Sen. Ed McBroom and U.S. Representative Jack Bergman.“I am excited to have the Senator and Congressman in our district,” Markkanen said. “These legislators have done outstanding work for our state and I look forward to seeing everyone.”The schedule is as follows:Friday, June 285 to 6 p.m. EDT at Keweenaw Coffee Works, 113 5th St. in Calumet.With Special Guest Ed McBroom. All times are listed in local time. Residents also may contact Rep. Markkanen at his Lansing office at (517) 373-0850 or read more

A range of Chello Zone channels in Europe the Mid

first_imgA range of Chello Zone channels in Europe, the Middle East and Africa have been rebranded as CBS services from today.Zone Romantica, Zone Reality and Zone Europa have been renamed as CBS Drama, CBS Reality and CBS Europa respectively under the extension of an agreement that originally applied to Chello Zone’s channels in the UK. The new-look channels will be reprogrammed to include series and TV movies from CBS’s library of over 70,000 hours of titles.last_img

YouView the UK digital TV jointventure platform

first_imgYouView, the UK digital TV joint-venture platform used primarily by BT and TalkTalk TV customers, aims to tap artificial intelligence and voice-based navigation to identify who is watching and present content based on who is watching and factors such as the time of day, according to Sion Wynn Jones, product director, YouView.Speaking at the OTT TV World Summit in London, Wynn Jones said that for viewers who do not know what they want to watch, the key is to delivering engagement is to provide great content discovery, and YouView will bring AI technology to bear on this problem.“What we need to do is use technology to…infer who is in front of the TV”, he said.YouView has now completed “the instrumentation of data on the platform”. Historic consumption data can be used to surface content that users want to watch while AI can also be brought to bear by analysing the way individual users search for content in particular contexts.As part of this drive, YouView has been working with Amazon on the use of voice search. Wynn Jones said that analysing who is speaking, what is the time of day and who else is likely to be in the room will enable YouView to surface content that could appeal to whoever is watching at any given time.While a number of on-demand apps on the YouView service have their own log-ins and search mechanisms, Wynn Jones said that YouView was working to simplify multiple log-in processes together with public broadcast partners. He said multiple log-ins for apps would “not prevent us from playing a role and our partners do see value in this”.He said that YouView’s public service broadcaster partners were “comfortable that we will respect their position as PSBs”Wynn Jones said that YouView’s main objective is to make “complexity simple” for its users. For users who know what they want to watch, the goal is “to get that content to them as quickly as possible”, through things like watch lists. Identifying who is likely to be in the room at a given time will also facilitate this, he said.Wynn Jones said that 21% of YouView homes watch over nine and a half hours of TV a day, although the platform operator has yet to identify how actively the service is being used for all of that time within those homes.last_img read more

I sincerely hope you and all of yours have a fanta

first_img I sincerely hope you and all of yours have a fantastic holiday season. I’m very excited about 2015. If you haven’t seen my 25% guarantee, you’ll want to take a look at it. I’ve upped the ante here at Casey Research with this offer: if you don’t make at least 25% on this one stock by Thanksgiving of 2015 (November 26), you’ll get 100% of your money back—no questions asked. That’s a bold move, yes. I’ve personally put a lot of money on this one, and I think it’s a must-own stock for any serious speculator. Before I get started, on behalf of everyone at Casey Research, I’d like to wish all of you a happy holiday season. This is the last Casey Daily Dispatch of the year—it will return next Friday, January 2, with another thought-provoking subject from Paul Rosenberg. We thank you for reading and sharing these columns. Whenever some big news involving Russia or Putin hits the wires, I get media requests from around the world. This past week was exactly that, and one particular interview stood out in my mind. I was interviewed by someone I’ve never been interviewed by before—and David Knight did a fantastic job. He did his homework, hit me with some tough questions, and the end result is one of the best interviews I’ve done.last_img read more

Recommended Link

first_img Recommended Link Justin’s note: Opportunities to make 50 times your money don’t come around often. But right now, one is staring us in the face. Today, we’re sharing a special essay from Casey Research founder Doug Casey. In it, Doug explains the rare opportunity shaping up in the gold market. As you’ll see, gold stocks could deliver historic gains in the years ahead…and now is the time to take advantage… By Doug Casey, founder, Casey Research My regular readers know why I believe the gold price is poised to move from its current level of around $1,250 per ounce to $1,500… $2,000… and eventually past $3,000. Right now, we are exiting the eye of the giant financial hurricane that we entered in 2007, and we’re going into its trailing edge. It’s going to be much more severe, different, and longer lasting than what we saw in 2008 and 2009. In a desperate attempt to stave off a day of financial reckoning during the 2008 financial crisis, global central banks began printing trillions of new currency units. The printing continues to this day. And it’s not just the Federal Reserve that’s doing it: it’s just the leader of the pack. The U.S., Japan, Europe, China… all major central banks are participating in the biggest increase in global monetary units in history. These reckless policies have produced not just billions, but trillions in malinvestment that will inevitably be liquidated. This will lead us to an economic disaster that will in many ways dwarf the Great Depression of 1929–1946. Paper currencies will fall apart, as they have many times throughout history. This isn’t some vague prediction about the future. It’s happening right now. The Canadian dollar has lost 33% of its value since 2013. The Australian dollar has lost 27% of its value during the same time. The Japanese yen and the euro have crashed in value. And the U.S. dollar is currently just the healthiest horse on its way to the glue factory. These moves show that we’re in the early stages of a currency crisis. But if you make the right moves, you could actually make windfall gains instead of suffering losses. Here’s how to do it… The huge winner during this crisis will be the only currency that has real value: gold. Gold has been used as money for thousands of years because it has a unique combination of qualities. Very briefly, it’s durable, easily divisible, convenient to carry, consistent around the world, and has value in and of itself. Just as important, governments can’t create gold out of thin air. It’s the only financial asset that’s not simultaneously someone else’s liability. When people wake up and realize that most banks and governments are bankrupt, they’ll flock to gold… just as they’ve done for centuries. Gold will rise multiples of its current value. I expect a 200% rise from current levels, at the minimum. There are many reasons, which we don’t have room to cover here, why gold could see a 400% or 500% gain. This should produce a corresponding bull market in gold stocks… perhaps of a magnitude we’ve never seen. A true mania for gold stocks could develop over the coming years. This could make anyone who buys gold stocks at their current depressed levels very rich. What History Teaches Us About Great Speculations Many of the best speculations have a political element to them. Governments are constantly creating distortions in the market, causing misallocations of capital. Whenever possible, the speculator tries to find out what these distortions are, because their consequences are predictable. They result in trends you can bet on. Because you can almost always count on the government to do the wrong thing, you can almost always safely bet against them. It’s as if the government were guaranteeing your success. The classic example, not just coincidentally, concerns gold. The U.S. government suppressed its price for decades while creating huge numbers of dollars before it exploded upward in 1971. Speculators who understood some basic economics positioned themselves accordingly. Over the next nine years, gold climbed more than 2,000% and many gold stocks climbed by more than 5,000%. The strategy that doesn’t work 99% of the time produces $2,100,000 A weird, newly revealed strategy could have made you $2.1 million DESPITE the fact that it doesn’t work on 99% of the stocks in the market. This strategy only works with a very, very small sub-niche of penny stocks, but it’s useless with blue chips, ETFs, dividend and tech stocks. However, within that small sub-niche, historical analysis shows this strategy would have a 95% accuracy rate and deliver average gains of 106%. Here’s the entire scoop on this unusual strategy, along with what specific sector of the market it profits from… Governments are constantly manipulating and distorting the monetary situation. Gold in particular, as the market’s alternative to government money, is always affected by that. So gold stocks are really a way to short government — or go long on government stupidity, as it were. The bad news is that governments act chaotically, spastically. The beast jerks to the tugs on its strings held by various puppeteers. But while it’s often hard to predict price movements in the short term, the long term is a near certainty. You can bet confidently on the end results of chronic government monetary stupidity. Mining stocks are extremely volatile for that very same reason. That’s good news, however, because volatility makes it possible, from time to time, to get not just doubles or triples but 10-baggers, 20-baggers, and even 100-to-1 shots. When gold starts moving higher, it’s going to direct a lot of attention towards gold stocks. When people get gold fever, they are not just driven by greed, they’re usually driven by fear as well, so you get both of the most powerful market motivators working for you at once. It’s a rare class of securities that can benefit from fear and greed at once. Remember that the Fed‘s pumping-up of the money supply ignited a huge bubble in tech stocks in the late ‘90s, and then an even more massive global bubble in real estate that burst in 2008. But they’re still creating tons of dollars. This will inevitably ignite other asset bubbles. Where? I can’t say for certain, but I say the odds are extremely high that as gold goes up, a lot of this funny money is going to pour into these gold stocks, which are not just a microcap area of the market but a nanocap area of the market. The combined market capitalization of the 10 biggest U.S.-listed gold stocks is less than 6% of the size of Facebook. I’ve said it before, and I’ll say it again: When the public gets the bit in its teeth and wants to buy gold stocks, it’s going to be like trying to siphon the contents of the Hoover Dam through a garden hose. Gold stocks, as a class, are going to be explosive. Now, you’ve got to remember that most of them are junk. Most will never, ever find an economical deposit. But it’s hopes and dreams that drive them, not reality, and even those without merit can still go up 10, 20, or 30 times your entry price. And companies that actually have the goods can go much higher than that. You buy gold, the metal, because you’re prudent. It’s for safety, liquidity, insurance. The gold stocks, even though they explore for or mine gold, are at the polar opposite of the investment spectrum; you buy them for their extreme volatility, and the chance they offer for spectacular gains. It’s rather paradoxical, actually. Why Gold Stocks Are an Ideal “Asymmetric Bet” Because these stocks have the potential to go 10, 50, or even 100 times your entry price, they offer something called “asymmetry.” You probably learned about symmetry in grade school. It’s when the parts of something have equal form and size. For example, cut a square in half and the two parts are symmetrical. Symmetry is attractive in some forms. The more symmetrical someone’s face is, the more physically attractive they are considered to be. Symmetry is often attractive in architecture. But when it comes to investing and speculating in the financial markets, the expert financial operator eschews symmetry. Symmetry is for suckers. The expert financial operator hunts for extreme asymmetry. An asymmetric bet is one where the potential upside of a position greatly exceeds its potential downside. If you risk $1 for the chance of making $20, you’re making an asymmetric bet. Amateur investors too often risk 100% of their money in the pursuit of a 10% return. These are horrible odds. But the financially and statistically illiterate take them. You might do better in a casino or most sports betting. It’s one of the key reasons most people struggle in the market. I’ve always been more attracted to asymmetric bets… where I stand a good chance of making 10, 50, even 100 times the amount I’m risking. I’m not interested in even bets. I’m only taking the field if my potential upside is much, much greater than my potential downside. Because of the extreme asymmetry gold stocks offer—because of their extreme upside potential when they’re cheap—you don’t have to take a big position in them to make a huge impact on your net worth. A modest investment of $25,000 right now could turn into $500,000 in five years. It has happened before and it will happen again. Right now gold stocks are near a historic low. I’m buying them aggressively. At this point, it’s possible that the shares of a quality exploration company or a quality development company (i.e., one that has found a deposit and is advancing it toward production) could still go down 10, 20, 30, or even 50 percent. But there’s an excellent chance that the same stock will go up by 10, 50, or even 100 times. I hate to use such hard-to-believe numbers, but that is the way this market works. When the coming resource bubble is ignited, the odds are excellent we’ll be laughing all the way to the bank in a few years. No one, including me, knows that the Mania Phase is just around the corner. But I’ve operated in this market for over 40 years. This is a very reasonable time to be buying these stocks. And it’s absolutely a good time to start educating yourself about them. There’s an excellent chance a truly massive bubble is going to be ignited in this area. If so, the returns are going to be historic. Regards, Doug Casey Founder, Casey Research Justin’s note: Casey Research’s resident gold stock specialist, Louis James, has just unveiled a proprietary strategy for selecting small gold stocks. Over a 30-year historical backtest, the strategy had a 95% success rate. Remarkably, the strategy even produced winning plays during gold’s $700 drop from 2011 to 2015. So, if the Mania Phase Doug predicts takes off, the asymmetrical gains you’ll see from these small gold stocks could hand you 10, 50, or even 100 times your money. Here, I explain the full story on Louis’ strategy so you can review it for yourself…center_img — Ledbetter Lee’s 1906 penny stock secret Ledbetter Lee worked with the legendary Rockefeller family in the early 20th century, though he’s all but forgotten by history. Despite that, Ledbetter’s creation helps predict which tiny penny stocks will go up. In fact, historical analysis shows this little-used tool would have helped produce gains of 291%… 327%… 674%… 345%… and 236%. Here’s how… — Recommended Linklast_img read more

Editors Note This story was originally published

first_imgEditor’s Note: This story was originally published on November 26, 2017 and has been updated.This week, an Instagram user who goes by the name of Jossa Johansson has come under fire for the caption of a post with a photo of herself embracing a little girl from Kibera, Kenya.”One of the happiest moment in your life was probably when you met me and my friends,” wrote Johansson. “I am sorry to tell you that there is a very slim chance we will ever meet again.”Johansson went on to write, “In two years you are going to meet a grown man that you have never met before and you two are going to have a child … if you are lucky … he will probably leave you alone … in your small home made of mud and tree’s. You will probably sell your body to someone else to earn money for your child.”She concluded: “I just want you to know there is hope, there is. Dreaming could be your saviour, dreaming could keep you alive. Dear child, keep safe.”Kenyans and other Africans and members of the African diaspora have called the post “pathetic” and “disgusting.”A tweet with screen grabs of the post has gone viral, with more than 37,500 retweets and 82,100 likes in just four days. “People in Kenya are not all desperate,” wrote one Twitter user.Johansson has since deleted the post and made her account private.The uproar reinforces the message of a joint campaign aimed at volunteers in developing countries: Think before you snap that photo (and write that caption).The campaign, launched just last fall, offers guidelines and a cheeky video to first-time travelers or young volunteers eager to capture every moment of their vacation or mission on Facebook or Instagram. It was created by Radi-Aid, a project of the Norwegian Students’ and Academics’ International Assistance Fund (SAIH) that fights stereotypes in aid and development, and by Barbie Savior, an Instagram parody account.According to the campaigners, the selfie takers may not realize that their posts, from the photo to the caption to the hashtags, can perpetuate stereotypes and rob the subject of dignity or privacy. A seemingly innocent selfie with African kids, for example, can perpetuate the idea that only Western aid, charity and intervention can “save the world,” says Beathe Ogard, president of SAIH in Norway. These children are portrayed as helpless and pitiful, Ogard says, while the volunteer is made out to be the superhero who will rescue them from their misery.Both Radi-Aid and Barbie Savior have gained a cult following for using satire and humor to tackle poverty porn, voluntourism and the white-savior complex. Radi-Aid, for example, made a viral video in 2016 titled “Who Wants To Be A Volunteer?” about a reality show whose grand prize is the chance to “Save Africa!” It has more than a million views.Barbie Savior spoofs volunteer photography by recreating popular images using Barbie dolls and Photoshop. A recent entry portrayed Barbie sitting on a pit toilet. The caption: “Did you know that 112 percent of the people living in the country of Africa don’t have access to toilets? #squatitlikeitshot.” The account has more than 120,000 followers.Despite their efforts, Barbie Savior and Radi-Aid have continued to observe “simplified and unnuanced photos playing on the white-savior complex, portraying Africa as a country, the faces of white Westerners among a myriad of poor African children, without giving any context at all,” Ogard says. The proliferation of these posts, she suspects, is the result of social media becoming a big part of how we communicate.That’s what makes the guidelines so crucial, says Adeela Warley, CEO of CharityComms, a network of communications professionals working in U.K.-based nonprofits. “In the age of instant communications, it’s too easy to press ‘go,’ ” she says. “You still see so many images that make [impoverished people] look passive and helpless as opposed to empowered. People need to take the time to think about the stories their [social media posts] are telling.”Ogard and the co-founder of Barbie Savior, Emily Worrall, hope that the guide will make young volunteers and travelers more aware of what they’re posting. Advice in the ten-point checklist includes: Be respectful of different cultures and traditions, avoid sweeping generalizations, challenge perceptions.The campaigners also want photo-takers to question their own intentions. Are they just posting the photos for “likes”?Worrall recalls her own experience a decade ago. When she was 17, she went on a volunteer trip to Uganda. She shared photos of herself and the orphans she was helping with her family and friends. They showered her with praise. “They told me, ‘Wow, you’re doing such amazing work.’ They put me on a pedestal,” she says. At the time, she didn’t consider the children’s privacy or vulnerability. Years later, it became inspiration for this Barbie Savior post:That image is one of many cliched visual tropes that Ogard and Worrall have observed. They shared examples of the kinds of photos volunteers should avoid when traveling to the developing world:Photos of volunteers giving candy or high fives to children. These can give the viewer the impression that such small gestures can change a child’s life when “in reality it has no impact. A lot of these people make empty promises and never come back to the community,” says Worrall, who has worked in Uganda as a development consultant for seven years. She recreated the image for Barbie Savior in August 2016.Photos of children on playgrounds. “We’re constantly reproducing these images that have no respect for informed consent,” Ogard says. “In Norway, I would never show up at a school and take a selfie with kids playing.”Photos of sick children in hospital beds. The campaigners illustrate this point in their animated video. The young volunteer takes a selfie with a sick child in a hospital bed while bored hospital staffers look on. “It completely disregards the child’s needs,” Worrall says.For years, communicators in the field of global development have been working to fight stereotype-reinforcing images in charity ads through awareness campaigns and codes of ethics. But few specifically address social media or are geared toward young people.Susan Krenn is the executive director of Johns Hopkins University’s Center for Communication Programs, and her work centers on global development and public health programs overseas. While the university has a cultural orientation program for students traveling abroad, there are no hard and fast rules for how to portray their experience on social media. “I have not seen a resource like this,” she says of the guidelines. “We’d use it. It’s quite helpful, clear and easy.”Ogard and Worrall don’t want the guidelines to discourage volunteers from posting photos on social media. They just want photo-takers to reflect on what they’re sharing. Ask for a subject’s consent, they say. Show your social followers something different.If you need inspiration, Worrall says, check out some of the positive imagery from charities that received a Golden Radiator award in Radi-Aid’s annual contest for the best and worst charity ads. These ads, like those from an NGO called Mama Hope, show local people actively engaged in helping others in their community.If you’re staying with a family in a low-income environment and they allow you to take a photo with their children, use it as a “great opportunity to challenge stereotypes,” Worrall says. That might mean providing details and context — names, locations, personal stories — in an extended caption on social media.And if a child gets excited when they see you pull out your tablet or smartphone and ask to take a photo with you, that doesn’t mean it’s OK to do so. “It’s a cop out to say, well, they want it,” Worrall says. “A child can’t make that kind of decision.””Think of how they would view the photo if they found it at 25 years old,” she adds. “How would it make them feel?”Your TurnHave you ever felt conflicted about taking a selfie with children in low-income countries? Share your experience with @NPRGoatsandSoda on Twitter. Copyright 2018 NPR. To see more, visit read more

Disabled people and other campaigners have reacted

first_imgDisabled people and other campaigners have reacted with shock, anger and concern to government proposals to consider forcing all sick and disabled people on out-of-work disability benefits to take part in “mandatory” activity.Disability News Service (DNS) revealed last week that the new work, health and disability green paper suggests that all claimants of employment and support allowance (ESA) with the highest support needs could be told to stay in regular touch with their local jobcentre, or risk having their benefits sanctioned.The green paper, Improving Lives, says ministers “could consider implementing a ‘keep-in-touch’ discussion with work coaches” for all people in the ESA support group, which “could provide an opportunity for work coaches to offer appropriate support tailored to the individual’s current circumstances” and “could be explored as a voluntary or mandatory requirement”.Paragraph 114 of the green paper goes on to say that such contact could use “digital and telephone channels in addition to face-to-face contact, depending on which was more appropriate for the individual and their circumstances”.Penny Mordaunt (pictured), minister for disabled people, appeared to confirm the proposal in the Commons this week, after she was asked about the future provision of employment advice for people in the support group.She told MPs the government was “consulting to establish if a ‘keep in touch’ discussion would be of benefit for this group, and if so, how and by whom should it be delivered, to ensure it meets the needs of individuals in this group”.Many disabled people reacted with horror to the story on the DNS website.Guy Stewart said: “Sanctions! Making us believe that our inability to gain work is our fault, when it absolutely is not, is cruel, but neatly fits into a government that constantly initiates dogma driven policy, rather then evidence driven policy.”“Sparkz_” said: “Will people have to phone from their hospital bed to keep in touch?”In response to Sparkz_, Jeffrey Davies said: “Been there done that, Atos at its best, in the high [dependency] unit. Ouch.”Rowan Farmer said: “I’m now wishing my life away, I’m 61 and thanks to the government I have another five years of stress and worry about assessments, appeals, benefits sanctions, poverty and homelessness, so much so that I’m actually looking forward to reaching 66 just to get rid of the added stress on top of several chronic, deteriorating and very painful illnesses!”Brian Mcardle added: “Now you know why [Theresa] May wants rid of the Human Rights Act.”Among those to comment on the story on Facebook was Erika Garratt, who encouraged other disabled people to take part in the consultation*.She said: “Filled in the form to tell them how ridiculous this idea is. We should all do this. “I am in the support group and this scares me so much.”Keith Evans, who is also in the ESA support group, said: “I’d rather jack ESA in than be forced to work that surely would kill me.”Beth Von Black replied to Evans: “That’s what they want. They want to scare us so much that we stop claiming what we’re entitled to!”She added later: “I’ve answered a few questions in the consultation and sent it off; angry that us long term disabled are being hounded into employment regardless of the fact that we cannot work!”There was also strong opposition to the proposal on Twitter.Professor Susan L Parish, professor of disability policy at Brandeis University in Massachusetts, in the United States, said: “This failed miserably in the #USA, so they’ll try it in the #UK.”Tracey Herrington said: “What a surprise – another unethical u turn. Who are they actually kidding when talking about personalised support… This is a direct attack.”Rick Meister tweeted: “Are the Tories about 2 sink 2 yet another low re chronically ill/disabled? Any such scheme must be voluntary… help, not threats!”Warren Belcher said: “This is so devastating, I can’t begin to think of the consequences and I’m dreading the impact this will have for so many people I care about.”And Hannah Smith tweeted: “How is this even ethical? Surely defeats the whole point [of] ESA in the first place.”Disability Rights UK (DR UK) said the green paper would “pave the way for success only if it leads to a complete overhaul” of the work capability assessment, one which produces “a system that encourages and supports people to try work where they feel they can, rather than threatening people with sanctions if they do not comply with (sometimes meaningless) activities”.It said the government would only be able to halve the disability employment gap if employers changed their behaviour, but it pointed to the green paper’s failure to announce any new incentives or requirements on employers, such as requiring the public sector to award contracts to companies with a good track record in employing disabled people, or providing a “comprehensive” helpline for small employers.It called for “more enforcement of the Equality Act in relation to those employers who simply continue to discriminate”, and said that the government’s strategy “will only work if employers are nudged and required to employ disabled people in greater numbers”.It welcome proposals such as expanding employment-related peer support, more tailored job support and work experience for young disabled people.But DR UK warned that research by the Employment Related Service Association (ERSA) suggested a cut in funding – in the move from the current Work Programme and Work Choice to the new Work and Health Programme – from £750 million in 2013-14 to less than £130 million in 2017-18.The ERSA research suggests this will lead to a drop in the number of disabled people accessing such support from 300,000 from 2012-15 to 160,000 from 2017-20.Although DR UK said it was “absolutely opposed” to plans to cut payments to new claimants in the ESA work-related activity group from next April, it said that investing all of the savings from this policy into employment support “could help strengthen the support offer to disabled people”.Philip Connolly, DR UK’s policy and development manager, said: “We have waited almost three years for this green paper and disabled people deserve a plan as ambitious as the government’s manifesto commitment [on halving the disability employment gap]; the green paper isn’t that plan.“The government’s response to its consultation on the green paper is the chance to really deliver on a plan.”Jonathan Bartley, co-leader of the Green party, and the father of a disabled son, was highly critical of the green paper.He said: “It is extremely concerning that the DWP is considering forcing ‘mandatory activity’ on all sick and disabled people.“It is barbaric to expect someone with a terminal illness, or who has no chance of getting better, to maintain contact with a ‘work coach’.“The Green party believes society should care for those who are most in need, not place damaging and unnecessary demands on them.“We call on the Labour party and the Lib Dems to join us in opposing these proposals.”A DWP spokesman repeatedly refused to clarify the meaning of paragraph 114, but said: “People in the support group have limited capability for work-related activity, but this does not mean that they should be left without any support at all.“And we want to hear views from as broad a range of disabled people, disability charities, and anyone else with something to contribute, on what more can be done to support this group.”*A consultation on the green paper will run until 17 February 2017, and among the ways to comment are via an online survey and by emailing read more

6 Startup Events and News to Watch This Week

first_img Add to Queue 3 min read October 7, 2013 Austin Startup Week kicks off with a battle of the bands, the Shutdown threatens to thwart D.C.-area businesses, great minds connect at the Inc. 500|5000 awards, students party hard at College Fest… This week’s notable news and startup events for entrepreneurs:1. Austin Startup Week: Kick off the Austin Startup Week with a battle of the bands competition hosted by the Austin Technology Council on Oc. 7. For the rest of the time, discussions dubbed “Co-Founders Wanted” and “Intro to the Austin Startup Scene,” among others, offer to keep you in the know and networked up the wazoo. (Austin, Texas, Oct. 7 – 11)2. Shutdown continues: The U.S. federal government shutdown heads into its second week. Small businesses continue to feel the burn. (Oct. 1 – present) Surveys sink: And if last week was any indication, government surveys, upon which many business owners have come to rely for a gauge on the U.S. economy, will also be delayed. Last week, two surveys on construction spending and manufactured goods and the monthly jobs report were delayed. This week, four more surveys will get sidetracked. Private companies shelve workers too: Though not a federal agency, Lockheed Martin plans to furlough about 3,000 employees this week due to the government shutdown. Various other defense contractors including United Technologies also said they’d furlough workers if the shutdown continued.3. Create a power partnership: Join the Impact HUB for a free introductory workshop, the first in a four-part series, aimed at helping you build “a more effective and satisfying” business partnership. (San Francisco, Oct. 8)4. Get down to business at Inc. 500|5000: Check out the Inc. 500|5000 conference and awards ceremony where the “brightest, most successful” business minds come together to celebrate achievements in private enterprise. This three-day event also features high-level keynote speakers and networking opportunities. (Washington D.C., Oct. 10 – 12)5. Tap the college market: Join the party or the exhibition at College Fest, which claims to be the “most attended back-to-school even in New England.” With more than 17,000 students in attendance, brands are lining up to put their products in the hands of this sought after demographic. (Boston, Mass., Oct. 12-13)6. Meet up with tech treps in NYC: Meet, mingle and make lasting relationships with some of Silicon Alley’s leading entrepreneurs at the NY Tech Meetup, for a night of live demos and networking. Aimed at promoting the NY tech scene and innovative, sustainable businesses, this event is a bargain at $10 a head. (New York, Oct. 8) The only list that measures privately-held company performance across multiple dimensions—not just revenue. Image credit: ATC Battle of the Bands –shares Apply Now » 6 Startup Events and News to Watch This Week Opinions expressed by Entrepreneur contributors are their own. 2019 Entrepreneur 360 List Technology Austin Startup Week kicks off with a battle of the bands, hosted
by Austin Technology Council. Next Article Brad Crescenzolast_img read more

Google Faces Lawsuit Over Kids InApp Purchases

first_img Next Article Register Now » Staff Writer. Covers leadership, media, technology and culture. –shares Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Entrepreneur Staff Google Faces Lawsuit Over Kids’ In-App Purchases center_img Google Nina Zipkin A class-action suit was filed against Google last week by parents of children who downloaded free or low-cost apps and games in the Google Play store and proceeded to rack up some sizable in-app fees. A New York woman’s 5-year-old son downloaded a 99-cent offering from Marvel Games called Marvel Run Jump Smash! to a Samsung Galaxy tablet and bought $65.95 worth of in-app purchases, according to a GigaOm report.Per a recent change to the Google Play store in February, app descriptions (including the game in question) now include a line letting users know whether or not they include in-app purchases. However, as it stands now, while you have to enter your password to buy apps, Google allows users to make further purchases for up to 30 minutes afterwards.   Related: French Courts Force Google to Air Indiscretion on Homepage The attorneys behind the suit allege that many apps in the Google Play store are geared toward young consumers, and that they are “engineered to be highly addictive and require the purchase of in-game currency at times to continue playing. The games frequently permit the purchase of in-game currency in large amounts – as much as $100 per purchase or more.”Apple has also been the subject of similar complaints. Last year, the company paid $5 million to settle a comparable private class-action lawsuit, and also reached a $32.5 million settlement with the Federal Trade Commission in January. Apple now requires users to provide their passwords before making any in-app purchase. The Google case was also filed with the court where the Apple case was settled, the U.S. District Court for the Northern District of California.  Related: Life Coaches, Gamification and Augmented Reality: What to Expect in Mobile This Year 2 min read Add to Queue March 11, 2014last_img read more

Verizon Readies Bid for Yahoos Web Business While Google Also Looking for

first_img Free Webinar | July 31: Secrets to Running a Successful Family Business This story originally appeared on Reuters Register Now » –shares Verizon Communications Inc. is ready to make a bid for Yahoo’s web business, and hopes to make a merger more successful by also making an offer for a stake in Yahoo’s Japan subsidiary, Bloomberg reported on Thursday, citing a source familiar with the matter.The telecom giant is planning to make a first-round bid for Yahoo’s web business next week, the news organization said.Alphabet Inc.’s Google unit is also mulling a bid for Yahoo’s core business, Bloomberg reported, citing a source. However, Bloomberg said many companies that had been seen as likely investors in Yahoo were not planning a bid, including AT&T Inc., Comcast Corp. and Microsoft Corp.Shares of Yahoo fell just over 1 percent to $36.17.Verizon, Yahoo and Google declined to comment for this story. AT&T, Comcast and Microsoft could not be reached immediately for comments.Verizon showed interest in Yahoo’s core business as early as December, when Chief Financial Officer Fran Shammo said the company would “see if there is a strategic fit” for its holdings, which include mail, news, sports and advertising technology.Yahoo launched an auction of its core business in February after it shelved plans to spin off its stake in Chinese ecommerce giant Alibaba Group Holding Ltd.The offer to purchase Yahoo’s 35.5 percent stake in Yahoo Japan could put Verizon one step ahead of any rival bidders.The offer will also likely leave Yahoo Chief Executive Officer Marissa Mayer out of the mix, since Verizon CEO Lowell McAdam said in a recent television appearance that merging Yahoo’s assets with AOL assets under the leadership of AOL CEO Tim Armstrong “would be a good thing for investors.”The New York Post reported last month that Mayer has been working to team up with private equity firms to create a “package deal” that sells the company and keeps her at the helm.Verizon shares were down 2.84 percent.(By Deborah M. Todd; Additional reporting by Rishika Sadam in Bengaluru; Editing by David Gregorio) Learn how to successfully navigate family business dynamics and build businesses that excel. Add to Queue Yahoo!center_img Image credit: Katherine Welles / Shutterstock Verizon Readies Bid for Yahoo’s Web Business, While Google Also Looking for a Piece April 7, 2016 Reuters 2 min read Next Article last_img read more

Arvind Fashions Partners With Nucleus Vision to Create a More Seamless and

first_imgArvind Fashions Partners With Nucleus Vision to Create a More Seamless and Personalized Shopping Experience PRNewswireMay 10, 2019, 6:55 pmMay 10, 2019 Deploys Nucleus Vision’s Proprietary Sensor Technology in Gap, Nautica & U.S. Polo Assn. Stores to Offer a Personalized Shopping Experience to Consumers As modern-day shoppers are inclining more towards personalization, Indian clothing retail chain Arvind Fashions Limited is exploring new ways to understand their customers better. Arvind, a licensee of numerous international fashion brands, has signed an MoU with Nucleus Vision, an IoT & Blockchain company, to initiate a pilot project aiming to offer a personalized experience to their shoppers.Following the partnership, Arvind will implement Nucleus Vision’s proprietary sensor technology in their Gap, Unlimited and US Polo. Assn. stores to strengthen customer analytics.“We see tremendous interest from the customers for a more evolved and personalized shopping experience. Nucleus Vision’s revolutionary technology will give us valuable insights into our customer behavior, which will help us improve customer satisfaction and increase revisits,” said Rukaiya Rangwala, COO, Digital Centre of Excellence, Arvind Fashions Limited.Marketing Technology News: Brainshark Wins in The American Business Awards for 8th Year in a Row“We look forward to expanding the scope of our relationship with Arvind Fashions Limited. This is a big step towards our goal to associate with the leading players in the Indian retail market to help them create better shopper experience,” said Abhishek Pitti, Founder & CEO of Nucleus Vision.The current Indian retail market amounts to an approximate of USD 800 billion and is estimated to reach USD 1.1 trillion by 2020. Personalization plays a major role in the gigantic market as 63% of Indian consumers prefer personalized experience, according to a report by Forrester-Epsilon. Through this association with Nucleus Vision, Arvind Fashions Limited intends to offer its consumers a more personalized retail shopping experience and therefore tap into new opportunities.Marketing Technology News: Pureport Announces Feature Enhancements to Its On-Demand Cloud Connectivity PlatformArvind Fashions Limited is India’s largest fashion and retail company, home to over 20 national and international brands. With 1500 stand-alone stores and 5000 departmental and multi-brand stores across India, Arvind Fashions Limited is a pioneer in introducing global brands into India.The company has successfully introduced ARROW, the first international menswear brand in India in 1993 and today licenses several brands like GAP, GANT, Nautica, Aeropostale, U.S Polo Association, The Children’s Place, Ed Hardy, Sephora among others.  Arvind Fashions was responsible for establishing Flying Machine, India’s first iconic, home-grown youth apparel brand in 1980.The company also houses its own leading brands like Unlimited, True Blue, The Arvind Store, among others. With unique capabilities in sourcing, design, product development, strong distribution footprint, retail capabilities, channel linkages and management teams, Arvind Fashions is a trendsetter across segments- casualization, tweens, kids, beauty and athleisure.Marketing Technology News: New Research Reveals More Than Half of Marketers Are Not Delivering the Right Content Abhishek PittiArvindchain Arvind FashionsMarketing TechnologyNewsNucleus Visionpersonalization Previous ArticleCaptify and Publicis Media Release New Research Revealing Global Beauty Trends That Will Transform The Larger FMCG EcosystemNext Articleo9 Solutions Continues to Deliver Value with its Premier AI-powered Platform for Integrated Planning and Digital Operationslast_img read more

Researchers are developing brandnew method to cure brain tumors

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Apr 22 2019Scientists from Far Eastern Federal University (FEFU) in cooperation with colleagues from Blokhin Russian Cancer Research Center (Moscow), Switzerland, and Sweden for the first time studied proteins, which constitute WNT signaling pathway of the cancer stem cells of glioblastoma multiforme (GBM CD133+ CSCs), one of the most aggressive brain tumors. Researchers revealed a number of proteins, which are potential targets to attack during complex antitumor therapy. A related article was published in Oncology Reports.Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors that is extremely resistant to therapy. On average, patients with such diagnosis live for 15 months. Only 27% of patients live more than two years following the diagnosis. According to scientists, tumor resistance to treatment is associated with cancer stem cells, and, in particular, with the activation of WNT signaling pathways in them.WNT signaling pathways in human cells are responsible for a number of essential functions, including cell proliferation, i.e. their reproduction, and the ability to differentiate into other types of cells. Unfortunately, they can contribute to the proliferation of cancer cells.”The behavior of the stem cells of glioblastoma multiforme is an urgent spot calling for research in modern medicine. Irradiation, cytostatics, and contemporary targeted chemotherapy are almost ineffective against cancer stem cells. Our idea is to use radiation simultaneously with drugs that suppress DNA retrieval process in cancer cells, followed by aggressive chemotherapy, one of the strategic objectives of which is to attack cancer stem cells.” said Igor Bryukhovetskiy, the author of the research idea, the Director of the Department of Fundamental Medicine in the FEFU School of Biomedicine.Related StoriesHow cell-free DNA can be targeted to prevent spread of tumorsUsing machine learning algorithm to accurately diagnose breast cancerNew study to ease plight of patients with advanced cancerThe scientist emphasized that he and his colleagues for the first time have managed to study proteins that form the WNT signaling pathway and directly interact with its components in human CD133 + stem cells of glioblastoma multiforme. The researchers found out that the set of proteins (proteome) in glioblastoma stem cells differs fundamentally from the one in other types of tumor cells. Scientists have also recognized other potential targets, the massive suppression of which can lead to a significant improvement of complex antitumor therapy outcome. These important results need further refinement during new in-depth research.How to affect the glioblastoma cancer stem cells is a conundrum far from a trivial. To crack one has engaged the world best laboratories.”In our research, we proceed from the fact we have proved previously: cancer stem cells execute their full potential when building up a bloodstream of a tumor, significantly accelerating its growth rate. Suppression of WNT-signaling proteins will allow increasing the effectiveness of anti-angiogenic therapy, i.e. treatment directed against the formation of new microvessels based on the vascular network already existing in the tissue. Such therapy is an integral part of the modern protocol for the comprehensive treatment of glioblastoma. The results of our studies can be brought into clinical practice in the near future.” summed up Igor Bryukhovetsky. Source: read more

Blood based test using AI and nanotechnology devised for chronic fatigue syndrome

first_img A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) R. Esfandyarpour, A. Kashi, M. Nemat-Gorgani, J. Wilhelmy, R. W. Davis Proceedings of the National Academy of Sciences Apr 2019, 201901274; DOI: 10.1073/pnas.1901274116 Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome F Ciregia, L Kollipara, L Giusti, R P Zahedi, C Giacomelli, M R Mazzoni, G Giannaccini, P Scarpellini, A Urbani, A Sickmann, A Lucacchini & L Bazzichi Translational Psychiatry volume 6, page e904 (2016) Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics Dorottya Nagy-Szakal, Dinesh K. Barupal, Bohyun Lee, Xiaoyu Che, Brent L. Williams, Ellie J. R. Kahn, Joy E. Ukaigwe, Lucinda Bateman, Nancy G. Klimas, Anthony L. Komaroff, Susan Levine, Jose G. Montoya, Daniel L. Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn & W. Ian Lipkin Scientific Reportsvolume 8, Article number: 10056 (2018) Ron Davis is the senior author of a paper that describes a blood test that may be able to identify chronic fatigue syndrome. Image Credit: Steve Fisch By Dr. Ananya Mandal, MDApr 29 2019People suffering from chronic fatigue syndrome (CFS) have been up until now treated with scepticism at best. Their symptoms have been negated as vague and their debilitating condition has not received the status of being proven in a test. No more now!Researchers from Stanford University School of Medicine have devised a blood based test that can accurately identify blood biomarkers that determine that a person is suffering from this condition. This provides a scientific proof that the disease does exist.Lead author and researcher Ron Davis, a professor of biochemistry and of genetics said in a statement, “Too often, this disease is categorized as imaginary.” On visits to the doctor the patient is usually prescribed a battery of tests for the liver, kidney and heart, blood and immune cells. He explained, “All these different tests would normally guide the doctor toward one illness or another, but for chronic fatigue syndrome patients, the results all come back normal.”center_img In their endeavours, Davis and Rahim Esfandyarpour, a former Stanford research associate and now faculty at University of California-Irvine, along with others have devised a blood based test to detect CFS. The test basically looks at the response of the immune cells to stress. The team in their pilot study took blood samples of 40 people. Of these 20 were diagnosed to be suffering from CFS based on their symptoms. The tests results could accurately pinpoint all the cases of CFS and did not make a diagnosis in any of the healthy persons.The researchers hope that this test could soon be modified and studied in depth to develop drugs to treat the condition as well. The team is using similar principles to look for drugs that could potentially help people with this condition. The study titled “A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS),” described the study findings and the results were published in the journal Proceedings of National Academy of Sciences.DiagnosisTypically CFS is diagnosed on the basis of symptoms. There is extreme exhaustion, unexplained pain, sensitivity to light, fever, irritable bowel syndrome, lymph node swelling, sleep problems, problems of cognition etc. the problems are seen in the gastrointestinal system, immune system, hormone system, heart and the brain. All other disease conditions need to be ruled out before CFS is formally diagnosed. CFS is also called myalgic encephalomyelitis and can be called ME/CFS. In the United States alone there are over 2 million people who are diagnosed with CFS says Davis. Davis says that his own son suffers from the condition for over a decade and their study was an effort to help people like his son.For their test the team used a “nanoelectronic assay.” When the healthy plasma cells and immune cells are subjected to stress, there are minimal changes in energy. The devise sends in thousands of tiny currents into the plasma samples causing the immune cells to respond and react. The reactions of cells from CFS patients are different from those of healthy persons. The device is accurate enough to pick up these nano-signals and correlate it with the health of the sample. The bigger the electrical signals sent out from the cells – more is the change at a cellular level explain the researchers. They add that this means that the cells are “flailing” under stress and are not able to process the stress adequately. The spikes were clearly seen in the results of the samples from CFS patients compared to those from healthy controls. The team used “supervised machine learning algorithms” or artificial intelligence technology to rapidly detect these spikes. This made the test reliable as well as accurate.Related StoriesIntermittent fasting shown to improve blood glucose levelsNovel technique that uses nanotechnology and photonics prevents bacterial infections on surgical implantsRadiometer’s ABL9 blood gas analyzer awarded Red Dot Design AwardDavis said, “We don’t know exactly why the cells and plasma are acting this way, or even what they’re doing. But there is scientific evidence that this disease is not a fabrication of a patient’s mind. We clearly see a difference in the way healthy and chronic fatigue syndrome immune cells process stress.” The team is now recruiting more number of patients to expand their pilot study and to see if it works in large populations accurately.Esfandyarpour said, “Using the nanoelectronics assay, we can add controlled doses of many different potentially therapeutic drugs to the patient’s blood samples and run the diagnostic test again.” Thus he explained how they could use their nanotechnology based test to also screen for potential drugs to treat CFS. If the drugs worked, then they probably would reduce the spikes on the test he said. At present they have found a drug that could help restore healthy functions of the immune cells and the plasma. They hope that soon the drug could be tried on human patients in clinical trials wherein its benefits could be proved. The drug in question currently is approved by the Food and Drug Administration (FDA), they add.The study received funds from the Open Medicine Foundation.Bottom-up proteomicsA few years back researchers F. Ciregia and colleagues from University of Pisa, Leibniz-Institut für Analytische Wissenschaften, Germany, Università Cattolica, Rome, University of Aberdeen, IRCCS-Fondazione Santa Lucia, Rome and more collaborated to find mitochondrial changes that could help detect CFS.Their study titled, “Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome,” was published in the journal Translational Psychiatry back in 2016.The team looked at the cellular structures of a pair of twins’ saliva samples. They studied their mitochondrial proteins. Using “Nano-liquid chromatography electrospray ionization mass spectrometry (nano-LC-MS)” they studied the mitochondria that came from the platelets of the blood samples of the twins. They selected 3 proteins from the samples and correlated it with saliva samples from 45 healthy controls and 45 patients with CFS. The three proteins were “aconitate hydratase (ACON), ATP synthase subunit beta (ATPB) and malate dehydrogenase (MDHM)”.Results revealed that there was a rise in the ATPB and ACON proteins in patients with CFS. Authors conclude, “these results suggest that our potential markers could be one of the criteria to be taken into account for helping in diagnosis.” They also hoped that this test would help develop tailored treatments for patients with CFS.Metabolomic biomarkersIn a more recent study by Dorottya Nagy-Szakal from Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York and colleagues studied markers for CFS. Their study titled “Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics,” was published in July 2018 in the journal Nature Scientific Reports.The team discovered biomarkers from plasma as well as stool that could help detect CFS. They included 50 CFS patients and 50 healthy controls in their study. Their study showed that there was altered levels of “choline, carnitine and complex lipid metabolites.” Patients with CFS tended to have raised levels of plasma ceramide, they wrote.The authors hoped that from their study diagnostic tests could be devised for patients with CFS by detection of these biomarkers from stool and plasma samples and in future treatments could be strategized as well.Referenceslast_img read more

Multifunctional nanoparticles could revolutionize treatments for complex bone diseases

first_imgThe researchers have filed two patents for their technology so far and are preparing to conduct clinical studies of the nanoplatform over the coming years, aiming for the eventual commercialization of the system and its deployment in clinical therapy.‘The development of a single technology for the treatment of three different but frequently associated diseases, particularly among elderly people, will favor the industrial scale-up process, promoting the transition of nanotechnology-based treatments from research to healthcare,’ Vallet-Regi says. The idea is to create a toolbox in order to be able to select the appropriate building blocks of therapeutic agents and targeting mechanisms according to the disease being treated. This will enable us to customize nanoparticles specifically for each bone pathology, allowing the creation of a library of nanomedicines suitable for clinical trials and eventually clinical use.”Maria Vallet-Regi, Universidad Complutense de Madrid in Spain Activated by a doctorUsing the toolbox, doctors would be able to deploy nanoparticles of mesoporous silica, a robust and versatile nanomaterial, as customisable carriers for treatments, such as antibiotics to treat infections or proteolytic enzymes to break up cancer cells.These nanoparticles would then be injected into the patient, find their way to the afflicted area and be activated – providing targeted, effective therapy with lower toxicity and fewer side effects for people suffering from bone cancers, bacterial infections or bone density loss caused by osteoporosis.Crucially, the nanoparticles carrying therapeutic agents must reach their targets, which requires the development and incorporation of compounds capable of targeting specific cells and penetrating cell walls or traversing the biofilms created by bacteria. The nanoparticles can then be activated by a doctor to release their load of therapeutic agents directly at the site of the diseased bone using external stimuli such as ultrasound, ultraviolet light or magnetic signals.Related StoriesResearch sheds light on sun-induced DNA damage and repairEngineered stem cells offer new treatment for metastatic bone cancerLong-term follow-up of childhood cancer survivors is essential to maintain bone healthTo treat osteoporosis, a degenerative bone disease estimated to affect 200 million people worldwide, the VERDI team is planning to use the nanoparticles to deliver molecules capable of silencing certain genes associated with the disease in order to limit bone loss and promote bone formation. The nanoparticles will be designed with unique masking properties to enable them to penetrate the cell membrane and reach the cytoplasm inside. Early tests of a similar nanosystem in animal models in a separate project led by Vallet-Regi have already had highly promising results, demonstrating the accumulation of therapeutic nanoparticles at the site of neuroblastomas, a cancer that affects nerve tissue.From research to healthcare Reviewed by James Ives, M.Psych. (Editor)May 24 2019Diseases such as bone cancer and osteoporosis are frequently complex, with two or more disorders occurring simultaneously. To address the associated treatment challenges, the EU-funded VERDI project is developing an innovative multifunctional nanoplatform that would be capable of healing a number of currently hard-to-treat bone diseases using a unique, versatile and scalable system.Led by Maria Vallet-Regi at the Universidad Complutense de Madrid in Spain, the project marks a significant milestone on the path to effectively deploying nanotechnology-based treatments in healthcare.center_img The challenges we are addressing are immensely varied, since we are tackling three different bone pathologies each with its own peculiarities. For example, in bone cancer we find heterogeneous tumor cells difficult to treat with only one drug; in bone infection, bacteria develop a biofilm that impedes antibiotics from reaching their target; and in osteoporosis we must deal with accelerated resorption, the breakdown of bone tissue.”Maria Vallet-Regi Source:European Commissionlast_img read more

Deutsche Post digs deep to master parcel boom

German logistics group Deutsche Post DHL said net profits were down 5.2 percent year-on-year between January and March Explore further Citation: Deutsche Post digs deep to master parcel boom (2018, May 8) retrieved 18 July 2019 from German logistics group Deutsche Post DHL confirmed its annual forecasts Tuesday, showing confidence although first-quarter profits slipped in the midst of a package boom spurred by online shopping. SAP more ambitious after soaring Q1 profits © 2018 AFP This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Net profits lost 5.2 percent year-on-year between January and March, at 600 million euros, the group said, adding that the shrinkage was down to the introduction of new accounting rules.Operating, or underlying profit added 2.3 percent, reaching 905 million euros, while revenues slid 0.9 percent, reaching 14.7 billion.Deutsche Post noted that operating profits had fallen in its packages and ecommerce division, saying investments in items like electric delivery vans and international logistics improvements to keep pace with the boom in demand had eaten into the result.Meanwhile unfavourable exchange rates undermined income from business outside the eurozone.”Overall we had a good start into the year, although we have a lot of work ahead of us for the remainder of 2018,” chief executive Frank Appel said.Ecommerce would remain “the most important growth driver for our businesses,” he added, keeping the group “confident” of reaching its full-year targets.In 2018, Deutsche Post forecasts a 10-percent increase in operating profit to around 4.15 billion euros, on track for its longer-term goal to exceed 5.0 billion by 2020. read more

Google braces for huge EU fine over Android

first_img‘Financial incentives’In the Android file, the European Commission has accused Google of requiring mobile manufacturers such as Samsung and Huawei to pre-install its search engine and Google Chrome browser on phones, and to set Google Search as the default, as a condition of licensing some Google apps.Google Search and Chrome are as a result pre-installed on the “significant majority” of devices sold in the EU, the commission says. Google is facing a massive fine from the EU this week for abusing its dominant market position EU Competition Commissioner Margrethe Vestager spoke by telephone with Google chief Sundar Pichai on Tuesday night to tell him about the decision in advance, a source close to the matter told AFP.Vestager is expected to announce that Google abused its dominant position in the market by making tie-ups with phone makers like South Korea’s Samsung and China’s Huawei.Two European sources told AFP the fine would be “several billion euros” without giving further details. EU rules say Google could be fined up to 10 percent of parent company Alphabet’s annual revenue, which hit $110.9 billion in 2017.”The fine is based on the length of the infraction, but also on whether antitrust authorities believe there was an intention to commit the offence, and whether they excluded competitors or not,” said another source close to the matter.The European Commission, the 28-nation EU’s executive arm, refused to comment.The long-awaited decision comes as fears of a transatlantic trade war mount due to President Donald Trump’s shock decision to impose tariffs on European steel and aluminium exports.Denmark’s Vestager has targeted a series of Silicon Valley giants in her four years as the 28-nation European Union’s antitrust chief, winning praise in Europe but angering Washington.The case against Android is the most significant of three complaints by the EU against the search titan, which has already been hit with a record-breaking 2.4-billion-euro fine in a Google shopping case.Brussels has repeatedly targeted Google over the past decade amid concerns about the Silicon Valley giant’s dominance of internet search across Europe, where it commands about 90 percent of the market. EU competition commissioner Margrethe Vestager is expected to say Google abused its dominant market position and to impose a multi- billion dollar fine on the internet giant The complaint formally lodged in April also accuses Google of preventing manufacturers from selling smartphones that run on rival operating systems based on the Android open source code.Google also gave “financial incentives” to manufacturers and mobile network operators if they pre-installed Google Search on their devices, the commission said.Vestager’s other scalps include Amazon and Apple.The EU’s biggest ever punishment targeted Apple in 2016 when it ordered the iconic maker of iPhones and iPads to pay Ireland 13 billion euros ($16 billion) in back taxes that it had avoided by a tax deal with Dublin.The EU has also taken on Facebook over privacy issues after it admitted that millions of users may have had their data hijacked by British consultancy firm Cambridge Analytica, which was working for Trump’s 2016 election campaign.The Google decision comes just one week before European Commission chief Jean-Claude Juncker is due to travel to the United States for crucial talks with Trump on the tariffs dispute and other issues.Transatlantic tensions are also high after Trump berated NATO allies over defence spending at a summit last week, over his summit with Russian leader Vladimir Putin, and over the US president’s pull-out from the Iran nuclear agreement and Paris climate deal. Explore further © 2018 AFP EU set to fine Google billions over Android: sources Citation: Google braces for huge EU fine over Android (2018, July 18) retrieved 18 July 2019 from Google prepared Wednesday to be hit with huge EU fine for freezing out rivals of its Android mobile phone system in a ruling that could spark new tensions between Brussels and Washington. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Google employees sign protest letter over China search engine NYT

first_imgHundreds of Google employees have signed a protest letter over the company’s reported work on a censor-friendly search engine to get back into China, The New York Times said Thursday. Explore further © 2018 AFP Reports: Google won’t renew Pentagon contract to use AI The employees are demanding more transparency so they can understand the moral implications of their work, said the Times, which obtained a copy of the letter.It has been signed by 1,400 employees and is circulating on the company’s internal communications system, the newspaper said, quoting three people who are familiar with the document.The letter argues that the search engine project and Google’s apparent willingness to accept China’s censorship requirements “raise urgent moral and ethical issues.””Currently we do not have the information required to make ethically-informed decisions about our work, our projects, and our employment,” they say in the letter, according to the Times.Employee anger flared with a report earlier this month in The Intercept that Google is secretly building a search engine that will filter content banned in China and thus meet Beijing’s tough censorship rules.Google withdrew its search engine from China eight years ago due to censorship and hacking.The new project is said to be codenamed “Dragonfly.”The tech giant had already come under fire this year from thousands of employees who signed a petition against a $10-million contract with the US military, which was not renewed.With the secret project, Google employees are reportedly worried that they might unknowingly be working on technology that could help China hide information from its people.”We urgently need more transparency, a seat at the table, and a commitment to clear and open processes: Google employees need to know what we’re building,” the protest letter says, according to the Times.At a townhall gathering of employees on Thursday, Google CEO Sundar Pichai said the firm was committed to transparency, and that while it was “exploring many options”, it was “not close to launching a search product in China,” the Financial Times reported, citing a person present at the meeting.center_img Google employees are reportedly concerned about a secret censor-friendly search engine project for China Citation: Google employees sign protest letter over China search engine: NYT (2018, August 17) retrieved 18 July 2019 from This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Electronic driving systems dont always work tests show

first_img Testing finds flaws with electronic car safety systems Testing by AAA shows that electronic driver assist systems on the road today may not keep vehicles in their lanes or spot stationary objects in time to avoid a crash. © 2018 The Associated Press. All rights reserved. Explore further Citation: Electronic driving systems don’t always work, tests show (2018, November 15) retrieved 17 July 2019 from The tests brought a warning from the auto club that drivers shouldn’t think that the systems make their vehicles self-driving, and that they should always be ready to take control.AAA also said that use of the word “pilot” by automakers in naming their systems can make some owners believe the vehicles can drive themselves.”These systems are made as an aid to driving, they are not autonomous, despite all of the hype around vehicle autonomy,” said Greg Brannon, AAA’s director of automotive engineering. “Clearly having ‘pilot’ in the name may imply a level of unaided driving, which is not correct for the current state of the development of these systems.”The test results released Thursday come after several highly publicized crashes involving Tesla vehicles that were operating on the company’s system named “Autopilot.” The National Transportation Safety Board is investigating some of the crashes, including a March fatality that involved a Model X that struck a freeway barrier near Mountain View, California.The AAA findings are the second tests showing that the systems can’t handle every situation in real-world driving, including some that are relatively common. In August, the Insurance Institute for Highway Safety released tests that showed similar problems to the AAA study.The auto club tested the systems on four vehicles that had adaptive cruise control, lane-keeping assist and automatic emergency braking. Vehicles tested included the 2018 Mercedes-Benz S Class, the 2018 Nissan Rogue, a 2017 Tesla Model S and a 2019 Volvo XC40. In addition to Tesla’s Autopilot, Volvo calls its system “Pilot Assist,” while Nissan’s is named “ProPilot Assist.”Automakers generally say they tell drivers that their cars aren’t fully self-driving and that they should always be alert and ready to intervene.AAA says the vehicles drifted out of lanes and hugged lane markers, struggling with moderate traffic, curved roads and streets with busy intersections. Three of the four would have failed to avoid a crash when the vehicle ahead of them changed lanes and a simulated stopped vehicle was ahead.”As a result we had to take evasive action,” said Brannon.Only the Tesla system brought the vehicle to a complete stop in all five track test runs, but driver intervention was needed for the others, the AAA report said.The vehicles’ owner’s manuals say that spotting a stationary vehicle after a lead vehicle changes lanes is a design limitation for the systems, Brannon said. But he said researchers expected the vehicles to see stopped vehicles and react in time.Automakers generally say that the systems are designed to supplement a human driver and they make it clear the vehicles don’t drive themselves.Nissan said its system name contains the word “assist,” showing that it’s designed to help the driver.”Mercedes-Benz has always stressed that this technology is designed to assist the driver, not to encourage customers to ignore their responsibilities as drivers,” the automaker said in a statement.Tesla says that it reminds drivers to keep their hands on the wheel. “Tesla has always been clear that Autopilot doesn’t make the car impervious to all accidents,” the company said in a statement earlier this year.A message was left Thursday seeking comment from Volvo.Brannon said that despite their shortcomings, the systems have great potential to save lives and stop crashes from happening.”Anything that can serve as a backstop to a good driver is going to enhance the safety of the system, of the driver,” he said. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. In this March 23, 2018 file photo provided by KTVU, emergency personnel work a the scene where a Tesla electric SUV crashed into a barrier on U.S. Highway 101 in Mountain View, Calif. The test results by AAA released Thursday, Nov. 15, 2018, come after several highly publicized crashes involving Tesla vehicles that were operating on the company’s system named “Autopilot.” The National Transportation Safety Board is investigating some of the crashes, including the March fatality that involved a Model X that struck a freeway barrier. (KTVU via AP, File)last_img read more