Despite the “unpredictable” and highly technical nature of the 110-metre hurdles, 25-year-old Hansle Parchment believes he has enough experience and confidence to upstage his main rivals and win Jamaica’s’ first-ever gold in this event at this year’s Rio Olympics in Brazil.”Everyone is potentially a medal winner, it (110m hurdles) is a very unpredictable event and anyone can win,” said Parchment, adding “very, very difficult in my discipline. Sometimes you are very relaxed and that’s when you are running faster, sometimes you tense a bit and that’s when you slow down. So it’s unpredictable.”He first crafted his hunt for supremacy with gold at the 2011 World University Games.Parchment is now Jamaica’s most successful hurdler, courtesy of an Olympic bronze medal from the 2012 London Olympics and silver at the IAAF World Championships in Beijing, China, last year.”You don’t know when you will run fast. You just have to work on your technique and set goals each time, and go with God,” he continued.With regard to this summer’s Olympics in Rio de Janeiro, Brazil, he said of his target: “Gold. I am aiming for the highest, once I am healthy.”I am working really hard and I feel I can be among the top three,” he told The Gleaner.13-SECOND BARRIERThe former University of the West Indies athlete also holds a place in local history as the first Jamaican to break the magical 13-second barrier.”I am very positive, I feel good, and remaining healthy is the main aim for this season. Once I can keep healthy, I will perform very well and I am really looking towards the Olympics this year, I think it will be great for a lot of people,” Parchment said, while tipping himself to medal.Coached by the legendary Fitz Coleman, Parchment has already achieved what former outstanding Jamaican hurdles giants like Keith Gardner and Maurice Wignall before him did not.He, however, maintains not taking anything for granted.”I work tirelessly on getting my technique better each year. With this hard work that I am putting in, I want to give some really great performances this year.”
Ryanair has been granted an injunction from the High Court this morning (Weds) preventing a planned strike over the next two days by some of the airline’s pilots based in Ireland.Around 180 pilots who are members of the Irish Air Line Pilots’ Association, which is a branch of the Fórsa union, were due to take industrial action tomorrow and on Friday in a dispute over pay and conditions.It follows a ballot of eligible IALPA members which was passed by the overwhelming majority of those who took part. Ryanair sought an injunction preventing Fórsa and 11 named individuals from proceeding with the work stoppage, which was due to get under way after midnight tonight.According to RTE, during two days of High Court hearings, the airline argued a strike would be a breach of an agreement put in place following a series of strikes at Ryanair last year.It requires any matters of dispute between the two sides to be referred to an independent mediator and to go through a dispute resolutions process before industrial action can take place.Ryanair also claimed that the secret ballot that led to the vote in favour of industrial action was unlawful. However, the union strenuously denied this and told the court it had been conducted according to union rules and the law.It also claimed that its current pay claim is not covered by the terms of the 2018 agreement.Ryanair strikes halted as airline granted High Court injunction was last modified: August 21st, 2019 by Staff WriterShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)
SAN JOSE — Will Sharks captain Joe Pavelski return to the ice for tonight’s win-or-go-home Game 7 NHL playoff game against the Colorado Avalanche at the Shark Tank?One authority thinks there’s a good chance.“I’m 75 percent sure he will play,” his wife, Sarah Pavelski, said Wednesday morning. “He’s hoping to, but wants to see the doctors one more time this morning to be sure.“Joe is feeling good.” Pavelski’s return could provide a huge emotional boost in the Sharks’ quest for a …
ST. LOUIS — The Giants have enjoyed modest success mining the waiver wire for under-the-radar, unproven talents this year.They’re hoping infielder Corban Joseph can follow in the footsteps of players such as Alex Dickerson and Trevor Gott and make an impact in a new spot.The Giants announced Tuesday they’ve claimed Joseph off waivers from the Oakland A’s. To clear a space on the 40-man roster for Joseph, San Francisco transferred infielder Pablo Sandoval to the 60-day injured list.Sandoval …
The Mizoram police sent back eight young Rohingya women, suspected to be victims of human trafficking, to neighbouring Assam on Friday after they were arrested near the border of the two States in Kolasib district a day ago, police said. The women , aged between 18-22, were produced before a fast-track court, which fined them ₹50 each and ordered that they be pushed back to Assam, police said.The State police handed them to the Young Muslim Association of Bagha town in Assam’s Cachar district. The women have been identified as Toyabah Begum, Tasim, Noorkayash, Atariza, Swaminara Begum, Rubina, Sanwara Begum and Serkhu.
About the authorCarlos VolcanoShare the loveHave your say Sergio Ramos hails Real Madrid ‘hunger’ for victory at Sevillaby Carlos Volcanoa month agoSend to a friendShare the loveSergio Ramos hailed Real Madrid’s “hunger” for victory at Sevilla.Karim Benzema scored the only goal of the game as Zinedine Zidane’s side bounced back from their 3-0 defeat to Paris Saint-Germain in midweek.”We knew how difficult the game was going to be as it’s been years since we won here,” Ramos told Movistar+ at full time.”We came with a very strong mentality and with the intention of making as few mistakes as possible.”Even though Sevilla had possession, we always knew we’d have little of the ball and when we did have it we took advantage of it.”We achieved the objective and we stayed calm this week, after everything that was said.”Real Madrid are always hungry to win.”The team is always very optimistic.”The team is improving.”This is very long, we’ve drawn level with Athletic Club in the table and we have to keep trying to improve as a team and especially to take chances like we did today.”
Grammy Award-winning powerhouse hip hop group The Roots and pop sensation Fifth Harmony will join a stellar music lineup that includes Jessie J, Nick Jonas, Meghan Trainor, Echosmith and The Vamps for the Nickelodeon HALO Awards, premiering Sunday, Nov. 30, at 7 p.m. (ET/PT).Jam-packed with one-of-a-kind performances, the hour-long special celebrates five kids who are “Helping and Leading Others” (HALO) in their communities. The concert will be capped by a must-see, all-star finale led by The Roots.Nickelodeon HALO Awards will also feature special appearances by Zendaya and Carlos PenaVega, along with stars from Nick’s hit series Instant Mom (Sydney Park), The Thundermans (Jack Griffo, Kira Kosarin), The Haunted Hathaways (Benjamin Flores Jr., Breanna Yde) and Victorious (Leon Thomas, Matt Bennett).Creator and executive producer Nick Cannon will host the festivities from New York’s Pier 36 and the event will air across Nick networks (Nickelodeon, TeenNick, Nicktoons), in addition to streaming live for the first time ever on Nick.com, the Nick App and Nick Radio.This year’s five Nickelodeon HALO Awards honorees are: • Lulu Cerone, 15, Los Angeles, Calif. ‐ Through her organization LemonAID Warriors, Lulu Cerone brainstorms, plans events and coordinates “PhilanthroParties,” which mix charity work with regular kids’ festivities using easy-to-follow toolkits. Following her own model, Cerone raised over $58,000 for water projects in Africa, $33,000 for local organizations, and has personally helped plan nearly 200 Philanthro-Parties across the U.S. • Yash Gupta, 18, Irvine, Calif. – After an accident left him without his eyeglasses for a week, Yash Gupta was inspired to start Sight Learning, an organization that collects and donates used eyeglasses, sets up eye exams, and gives the gift of sight to students around the world. Since 2010, Sight Learning has donated over 21,000 pairs of glasses to students in need across 14 states in the U.S. and in four countries. • Cassandra Lin, 16, Westerly, R.I. ‐ Cassandra Lin is the founder of Turn Grease into Fuel (TGIF), a sustainable program that collects waste cooking oil, from local residents and restaurants, then converts it into biodiesel fuel. The fuel is used to heat the homes of families in need. With 145 participating restaurants and businesses in 22 towns and 20 public receptacles throughout three states, TGIF has collected over 170,000 gallons of waste cooking oil and helped heat the homes of over 290 families to date. • Nicholas Lowinger, 16, Cranston, R.I. ‐ Gotta Have Sole – After an enlightening visit to a local homeless shelter, Nicholas Lowinger started Gotta Have Sole in 2010 to provide brand-new footwear to underprivileged children across the United States. To date, the organization works with shelters in 35 states and has provided brand-new shoes to over 21,500 underprivileged kids, giving them the confidence and means to go to school, socialize, succeed and live healthier, happier lives. • Alanna Wall, 14, Dayton, Ohio – Striving to brighten the lives of young girls, Alanna Wall created Polished Girlz, an organization that brings trendy nail art parties to those with special needs and frequent hospitalizations. Since its inception in 2011, over 800 volunteers are currently painting girls’ nails in over 25 national chapters in North America.Nick.com/halo and the Nick App are the official digital destinations for all things HALO. Kids will be able to learn all about the HALO Awards, relive the best performances from last year’s show, watch videos featuring Nick Cannon and all of this year’s musical acts, flip through photo galleries featuring kids who have HALO’d, find out which celebs will have a front row seat to this year’s concert event, and score some exclusive sneak peeks before the show. On Nov. 30, kids can watch the concert special unfold through a live photo stream featuring images of their favorite Nick Stars, Nick Cannon, Meghan Trainor and more. Plus, for the first time ever, Nick.com and the Nick App will feature a live video stream of the HALO Awards so kids can watch the show anywhere.Currently in its sixth year, Nickelodeon HALO Awards is an annual awards show that recognizes real-life kids that are doing extraordinary things in their communities and “Helping and Leading Others” (HALO). In addition to being awarded a grant for their organization and scholarship funds, each HALO Award honoree is given an once-in-a-lifetime opportunity to meet and connect with celebrities that share their same passion for service.Presenting sponsors of the annual Nickelodeon HALO Awards are Green Giant, Reese’s Puffs Cereal and Dave & Buster’s.The Nickelodeon HALO Awards is produced by Superfly in association with Nickelodeon Productions. Nick Cannon, Alex Coletti, Jay Schmalholz and Shelly Sumpter Gillyard are executive producers.Nickelodeon, now in its 35th year, is the number-one entertainment brand for kids. It has built a diverse, global business by putting kids first in everything it does. The company includes television programming and production in the United States and around the world, plus consumer products, online, recreation, books and feature films. Nickelodeon’s U.S. television network is seen in almost 100 million households and has been the number-one-rated basic cable network for 19 consecutive years.
De Vijver Media’s new shareholder structure.Telenet has bought a 50% stake in Belgium’s De Vijver Media, after buying Finnish media group Sanoma’s shares for €26 million and making an additional €32 million cash investment in the firm.De Vijver Media CEO Wouter Vandenhaute and his business partner Erik Watté keep 25 % of De Vijver Media through their company W&W, while Belgian media group Corelio also retains 25 % of the company’s shares.De Vijver Media owns media company SBS Belgium, the channels VIER and VIJF and production house Woestijnvis.With the deal, Telenet said that its long-term backing will give SBS and Woestijnvis “the necessary breathing space to develop their strategy further,” as well as new financial and technological possibilities for the Flemish audiovisual sector to continue predicting local programmes.“Our objective is to offer Flemish viewers the best and most modern multimedia entertainment. A participation in De Vijver Media should make this possible. Of course, this is not an obvious step for a cable company, but I am convinced that the Flemish media landscape can only get stronger with this participation and that Flemish viewers will benefit,” said Telenet CEO John Porter.Wouter Vandenhaute, CEO of De Vijver Media added: “Telenet’s investment allows us to look at the future with confidence. Woestijnvis wants to remain a strong and innovative production house and VIER and VIJF want to continue growing. A television landscape with, in addition to a public broadcasting corporation, two commercial players, offers the best guarantee in the long term to provide quality to Flemish viewers, who have been spoiled these last two years. Telenet will not only give us the necessary support, their technological know-how can also seriously help us to carve out a strong position in a sector which will evolve more and more over the coming years.”
Source:https://www.augusta.edu/mcg/ Reviewed by James Ives, M.Psych. (Editor)Nov 28 2018A lipid that helps keep skin cell turnover on track may help restore healthy turnover in psoriasis, investigators say.Topical application of the lipid phosphatidylglycerol, or PG, on a mouse model of psoriasis reduced inflammation as well as characteristic, raised skin lesions, they report in the Journal of Investigative Dermatology.They had already shown that PG has a role in both regulating the function of the major cell type in our skin called keratinocytes and suppressing skin inflammation.Now they have the first evidence that PG inhibits toll-like receptor activation by the antimicrobial peptides produced by those skin cells, says Dr. Wendy B. Bollag, cell physiologist in the Department of Physiology at the Medical College of Georgia at Augusta University.Toll-like receptors are a family of receptors that detect external invaders as well as internal damage signals then activate an immune response. Our skin is our largest organ and front line of defense, and a variety of skin cell types make antimicrobial peptides, which function like an endogenous antibiotic to help the skin protect us.The common skin condition psoriasis upsets the works by increasing both the production of skin cells and production of these antimicrobials by those cells.In some patients it may be a problematic immune system that initiates the vicious cycle of skin cells producing proteins called cytokines that call in more immune cells that make more cytokines that cause skin cells to make even more cytokines and excessively proliferate, says Bollag. In others, the antimicrobials may initiate the vicious cycle.Either way, more antimicrobials get produced which is probably beneficial since psoriasis also impairs the skin’s ability to prevent invaders.But these high levels of antimicrobials also produce an inflammatory response much like an invader’s might, resulting in the red, flaky patches that typically surface on high-touch areas like the elbows, forearms and knees and also show up on the scalp and elsewhere, says Bollag, the study’s corresponding author.Because at higher levels, the body sees these protective antimicrobial peptides as danger-associated molecular patterns, or DAMPS, which, as the name indicates, it views as signs of danger. DAMPS then activate toll-like receptors.It’s the increased and chronic level in psoriasis that heightens the awareness and response, says first author Dr. Vivek Choudhary, molecular biologist and physiologist in the MCG Department of Physiology.Once toll-like receptors get activated, the immune system makes proinflammatory cytokines that bring in T cells, which help drive the immune system attacks.”It’s actually T cells that help maintain the disease,” Bollag says, “But we are thinking that the innate immune system is sort of what initiates it,” she says of that toll-like receptor activation.In the continuing vicious cycle, all the immune action prompts the skin cells to actually make more antimicrobials in response to the perceived danger. “It’s a natural system that has kind of gone haywire,” she says.The investigators used S100A9 as their representative antimicrobial. In psoriasis, the levels of S100A9 correlate with the severity of the disease and, when treatment works, blood levels of S100A9 decrease.Related StoriesArtificial intelligence better than humans in diagnosing pigmented skin lesionsScientists discover how resistance to the chemotherapy drug 5-fluorouracil arisesHair loss could soon be a thing of the past, say researchersThey found that both in keratinocytes as well as inflammation-promoting immune cells called macrophages, PG suppressed activation of toll-like receptors by DAMPS, in this case S100A9.Next steps include finding a version of PG that can more easily permeate the skin since the larger lipid is a bit too big to easily pass through the natural barrier. Interestingly, psoriasis hinders the barrier function so PG can initially get through, but when the condition improves, PG’s access deteriorates, the investigators note.They suspect PG’s inhibition of toll-like receptors doesn’t just happen in psoriasis, but that constant fine tuning of the immune response is among its usual functions.”You want to be able to dial it up, but not go overboard,” Bollag says. “We think that may be part of the job of PG, to basically keep the immune system from going from zero to 60 in one second flat.”This is particularly important in body areas regularly exposed to the elements like the skin, lungs and gastrointestinal tract, she says. Maybe part of the problem with psoriasis is that this fine control no longer works well, she says.Inflammation in the absence of an infection is a hallmark of psoriasis. The resulting inflammation produces a “feed forward” response: Keratinocytes start to excessively proliferate and abnormally differentiate and the skin thickens.PG enables the normal differentiation of new skin cells as cells make their way up multiple layers, reach the surface and old cells slough off.PG is made from glycerin, a natural alcohol, water attractor and key component of many lipids, which helps skin look better and aids this healthy production and maturation of high-turnover skin cells. Glycerin is transported by aquaporin-3, which the MCG investigators believe is decreased in psoriasis versus healthy skin.Today there are a variety of topical treatments for psoriasis, including vitamin D analogues and glucocorticoids, but nothing that works great for all patients, Bollag says. Part of the problem likely is that psoriasis causes vary and the reality that they are mostly not understood. Systemic drugs also are given that generally suppress the immune response, which have obvious side effects like leaving patients susceptible to infection and cancer.Bollag doesn’t think PG will be a magic bullet either, but may one day be a good option for patients with mild disease or as an adjunct to other therapies.PG is also a component of surfactant, which enables the airs sacs in the lungs to properly inflate so we can breathe. It’s been shown to inhibit inflammation in the lungs induced by microorganisms and that it works there as well through toll-like receptors. Bollag notes these new findings about what happens in the skin are likely applicable to similar conditions, where this so-called “sterile inflammation” occurs in response to substances naturally found in the body.
A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) R. Esfandyarpour, A. Kashi, M. Nemat-Gorgani, J. Wilhelmy, R. W. Davis Proceedings of the National Academy of Sciences Apr 2019, 201901274; DOI: 10.1073/pnas.1901274116 https://www.pnas.org/content/early/2019/04/24/1901274116 Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome F Ciregia, L Kollipara, L Giusti, R P Zahedi, C Giacomelli, M R Mazzoni, G Giannaccini, P Scarpellini, A Urbani, A Sickmann, A Lucacchini & L Bazzichi Translational Psychiatry volume 6, page e904 (2016) https://www.nature.com/articles/tp2016184 Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics Dorottya Nagy-Szakal, Dinesh K. Barupal, Bohyun Lee, Xiaoyu Che, Brent L. Williams, Ellie J. R. Kahn, Joy E. Ukaigwe, Lucinda Bateman, Nancy G. Klimas, Anthony L. Komaroff, Susan Levine, Jose G. Montoya, Daniel L. Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn & W. Ian Lipkin Scientific Reportsvolume 8, Article number: 10056 (2018) https://www.nature.com/articles/s41598-018-28477-9 Ron Davis is the senior author of a paper that describes a blood test that may be able to identify chronic fatigue syndrome. Image Credit: Steve Fisch By Dr. Ananya Mandal, MDApr 29 2019People suffering from chronic fatigue syndrome (CFS) have been up until now treated with scepticism at best. Their symptoms have been negated as vague and their debilitating condition has not received the status of being proven in a test. No more now!Researchers from Stanford University School of Medicine have devised a blood based test that can accurately identify blood biomarkers that determine that a person is suffering from this condition. This provides a scientific proof that the disease does exist.Lead author and researcher Ron Davis, a professor of biochemistry and of genetics said in a statement, “Too often, this disease is categorized as imaginary.” On visits to the doctor the patient is usually prescribed a battery of tests for the liver, kidney and heart, blood and immune cells. He explained, “All these different tests would normally guide the doctor toward one illness or another, but for chronic fatigue syndrome patients, the results all come back normal.” In their endeavours, Davis and Rahim Esfandyarpour, a former Stanford research associate and now faculty at University of California-Irvine, along with others have devised a blood based test to detect CFS. The test basically looks at the response of the immune cells to stress. The team in their pilot study took blood samples of 40 people. Of these 20 were diagnosed to be suffering from CFS based on their symptoms. The tests results could accurately pinpoint all the cases of CFS and did not make a diagnosis in any of the healthy persons.The researchers hope that this test could soon be modified and studied in depth to develop drugs to treat the condition as well. The team is using similar principles to look for drugs that could potentially help people with this condition. The study titled “A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS),” described the study findings and the results were published in the journal Proceedings of National Academy of Sciences.DiagnosisTypically CFS is diagnosed on the basis of symptoms. There is extreme exhaustion, unexplained pain, sensitivity to light, fever, irritable bowel syndrome, lymph node swelling, sleep problems, problems of cognition etc. the problems are seen in the gastrointestinal system, immune system, hormone system, heart and the brain. All other disease conditions need to be ruled out before CFS is formally diagnosed. CFS is also called myalgic encephalomyelitis and can be called ME/CFS. In the United States alone there are over 2 million people who are diagnosed with CFS says Davis. Davis says that his own son suffers from the condition for over a decade and their study was an effort to help people like his son.For their test the team used a “nanoelectronic assay.” When the healthy plasma cells and immune cells are subjected to stress, there are minimal changes in energy. The devise sends in thousands of tiny currents into the plasma samples causing the immune cells to respond and react. The reactions of cells from CFS patients are different from those of healthy persons. The device is accurate enough to pick up these nano-signals and correlate it with the health of the sample. The bigger the electrical signals sent out from the cells – more is the change at a cellular level explain the researchers. They add that this means that the cells are “flailing” under stress and are not able to process the stress adequately. The spikes were clearly seen in the results of the samples from CFS patients compared to those from healthy controls. The team used “supervised machine learning algorithms” or artificial intelligence technology to rapidly detect these spikes. This made the test reliable as well as accurate.Related StoriesIntermittent fasting shown to improve blood glucose levelsNovel technique that uses nanotechnology and photonics prevents bacterial infections on surgical implantsRadiometer’s ABL9 blood gas analyzer awarded Red Dot Design AwardDavis said, “We don’t know exactly why the cells and plasma are acting this way, or even what they’re doing. But there is scientific evidence that this disease is not a fabrication of a patient’s mind. We clearly see a difference in the way healthy and chronic fatigue syndrome immune cells process stress.” The team is now recruiting more number of patients to expand their pilot study and to see if it works in large populations accurately.Esfandyarpour said, “Using the nanoelectronics assay, we can add controlled doses of many different potentially therapeutic drugs to the patient’s blood samples and run the diagnostic test again.” Thus he explained how they could use their nanotechnology based test to also screen for potential drugs to treat CFS. If the drugs worked, then they probably would reduce the spikes on the test he said. At present they have found a drug that could help restore healthy functions of the immune cells and the plasma. They hope that soon the drug could be tried on human patients in clinical trials wherein its benefits could be proved. The drug in question currently is approved by the Food and Drug Administration (FDA), they add.The study received funds from the Open Medicine Foundation.Bottom-up proteomicsA few years back researchers F. Ciregia and colleagues from University of Pisa, Leibniz-Institut für Analytische Wissenschaften, Germany, Università Cattolica, Rome, University of Aberdeen, IRCCS-Fondazione Santa Lucia, Rome and more collaborated to find mitochondrial changes that could help detect CFS.Their study titled, “Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome,” was published in the journal Translational Psychiatry back in 2016.The team looked at the cellular structures of a pair of twins’ saliva samples. They studied their mitochondrial proteins. Using “Nano-liquid chromatography electrospray ionization mass spectrometry (nano-LC-MS)” they studied the mitochondria that came from the platelets of the blood samples of the twins. They selected 3 proteins from the samples and correlated it with saliva samples from 45 healthy controls and 45 patients with CFS. The three proteins were “aconitate hydratase (ACON), ATP synthase subunit beta (ATPB) and malate dehydrogenase (MDHM)”.Results revealed that there was a rise in the ATPB and ACON proteins in patients with CFS. Authors conclude, “these results suggest that our potential markers could be one of the criteria to be taken into account for helping in diagnosis.” They also hoped that this test would help develop tailored treatments for patients with CFS.Metabolomic biomarkersIn a more recent study by Dorottya Nagy-Szakal from Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York and colleagues studied markers for CFS. Their study titled “Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics,” was published in July 2018 in the journal Nature Scientific Reports.The team discovered biomarkers from plasma as well as stool that could help detect CFS. They included 50 CFS patients and 50 healthy controls in their study. Their study showed that there was altered levels of “choline, carnitine and complex lipid metabolites.” Patients with CFS tended to have raised levels of plasma ceramide, they wrote.The authors hoped that from their study diagnostic tests could be devised for patients with CFS by detection of these biomarkers from stool and plasma samples and in future treatments could be strategized as well.References