Though the number of transfusion-transmitted WNV cases has decreased dramatically since testing began, a report in the Feb 2 Morbidity and Mortality Weekly Report detailed the cases of two South Dakota patients whose disease probably came from a single infected donor whose screening tests were negative at the time of donation. The CDC said the cases underscore the importance of clinical recognition, effective WNV blood screening strategies, and investigation coordination. The Procleix TIGRIS system, developed by Gen-Probe, Inc., San Diego, and marketed by Chiron Corp., Emeryville, Calif., was approved by the FDA on Mar 2 and uses Gen-Probe’s Procleix WNV assay, which is already being used in the company’s semiautomated screening system, Gen-Probe said in a March 2 press release. Mar 9, 2007 (CIDRAP News) The first fully automated test to screen donors of blood, tissue, and organs for West Nile virus (WNV) was recently approved by the US Food and Drug Administration (FDA). The automated system allows blood centers to process 1,000 individual blood samples in about 14 hours, Gen-Probe said. Blood testing sites typically use pooled samples to screen for WNV, then switch to individual donor testing once predetermined WNV prevalence triggers are met, the company said. “This is the latest step forward in what has been a very successful industry-government effort to keep blood safe from the emerging threat of West Nile virus,” he said in the press release. Mar 2 Gen-Probe press release WNV was first detected in the United States in 1999 and has since become endemic. For the 2006 season, 4,256 cases of West Nile virus have so far been reported to the Centers for Disease Control and Prevention (CDC); 1,449 cases involved West Nile encephalitis or meningitis, and 165 were fatal. People usually catch WNV from the bite of a mosquito that has picked up the pathogen from an infected bird or animal. Most people experience no symptoms or only mild illness, but the virus can cause serious infections of the brain and nervous system. Mar 2 FDA press release Development of a WNV blood test began in 2002 when researchers discovered that the virus could be transmitted in blood, and nationwide screening for the virus began in 2003. Testing detected about 1,400 potentially infectious blood donations from 2003 to 2005, according to the CDC. Feb 2 MMWR article on South Dakota caseshttp://www.cdc.gov/mmwr/preview/mmwrhtml/mm5604a4.htm CDC 2006 West Nile virus figures See also: The advantages of a fully automated system are that it can reduce the potential for human error, speed up donor screening, and enhance the safety of blood and tissue products, said Jesse Goodman, MD, director of FDA’s Center for Biologics Evaluation and Research, in a March 2 FDA press release.
Boston Celtics center Al Horford will not exercise the $30.1M option on his 2019-20 contract and become an unrestricted free agent, league sources tell ESPN. Horford and the Celtics both have interest in working toward a new deal in July, sources tell ESPN.— Adrian Wojnarowski (@wojespn) June 18, 2019Horford, 33, is coming off of a season in which he averaged 13.6 points and 6.7 rebounds while shooting 53.5 percent from the floor and 36.0 percent from beyond the arc.He is starting to get older and the team may want to restructure his deal so it can have more flexibility in free agency. Related News NBA free agency rumors: Kings prioritizing center, but unlikely to pursue Nikola Vucevic Al Horford and the Celtics want to extend their relationship.Boston’s center will decline his $30.1 million option this offseason and become an unrestricted free agent, but he is doing so in hopes of working out a new deal with the Celtics, according to ESPN. However, Rozier reportedly is open to returning if Irving doesn’t, so the Celtics likely will need a little bit more money to re-sign the guard.If Horford takes a pay cut then Rozier would likely be able to get his money.The Celtics currently are $16 million over the salary cap, according to Spotrac, but if Irving (option figure: $21.3 million) leaves then they would have some money to spend, especially if Horford agrees to a more team-friendly deal. Kyrie Irving is expected to decline his option as well and hit the open market with the Nets the reported favorite to land the guard in free agency.Jaylen Brown, Marcus Smart and Jayson Tatum are expected to remain in Boston, but players such as Marcus Morris and Terry Rozier could find themselves with new teams. NBA free agency: Patrick Beverley says he’s open to signing with Bulls