Rajputs’ protest over abduction continues

first_imgMembers of the Rajput community continued their protest for the third day on Saturday demanding arrest of those involved in abduction of a bride, the police said.The protesters gathered outside the Sikar district collectorate demanding strict action against the culprits, they said. “A group has been protesting and demanding the arrest of the suspects. The search for the bride and the prime suspect is on. As a preventive measure, internet services were suspended in the area till 6 p.m. on Saturday,” Additional SP Devendra Kumar Sharma said. Five people have been detained in connection with the incident whereas prime accused Ankit Sevda is still on the run, he said. On Wednesday, bride Hansa Kanwar was abducted by a group of armed men at gunpoint when she and her husband were on the way to their home. Hansa and her elder sister Sonu got married on Tuesday to two brothers from Nagwa village. After the wedding, when they were returning in a car from Nagwa village, the accused attacked the vehicle and abducted Hansa. The incident had occurred near Rambashpura area which comes under the jurisdiction of Dhod police station.last_img read more

News Analysis: Why Vidyasagar is important to the hoi polloi of Bengal

first_img| Photo Credit: Rajeev Bhatt  One of his key achievements was to push the British Legislative Council on widow remarriage, opposed by the bhadralok ruling class and religious bodies. He advocated education for all – especially women– and raising of the marriageable age of the girl child, which too was challenged by the ruling class. He also campaigned against polygamy. Modern Indian laws, pertaining to the subjects, are shaped partly on discourses first underscored in public space by Vidyasagar for which he was isolated.Tormented by bhadralokBeing severely tormented by the English-speaking bhadrolok of the 19th century, he left Kolkata in his declining years. In an interview, published in a book, Puratan Prasanga [past subjects], Vidyasagar concluded that he would never “teach English to children” in perhaps next life.“The attack on Vidyasagar indicates two things. One, that women’s emancipation lost its meaning in today’s Bengal and two that the bell has tolled for the Bengali language, which evolved with him, indicating its death,” said Shibaji Bandopadhyay, an eminent Kolkata-based scholar.Throughout the day, the issue of bust demolition dominated the social media. On ground, political parties and the civil society staged demonstrations and rallies and BJP leaders sounded apologetic, off record.But it may not affect BJP in all the nine seats that go to the polls on May 19, as the event is not commanded by its leadership. While the party can be critically examined for staging an unimaginably big rally on a not so wide lane, the police can also be questioned for not managing to keep the students and the TMC’s black flag waving supporters inside, triggering the incident.The TMC, however, argued that they “have the right to protest democratically” while the BJP said “TMC triggered the violence.”The results in three Kolkata seats would indicate who gained and who did not, once the results are out on May 23.“The question, however, is whether Bengal will forgive the perpetrators. Bengal never forgave the Naxals for similar action,” said Partha Sengupta, a former Communist Party of India activist.Mr. Sengupta organised the civil society to place Vidyasagar’s head on the pedestal after it was chopped off by ultra-left activists in 1970, albeit to underscore a completely different political thought. Burnt motorcycle near the Vidyasagar College in Kolkata on May 14, 2019.center_img On May 14, Tuesday, a few men clad in saffron shirts broke away from a mega rally of BJP president Amit Shah and entered a nondescript building in central Kolkata. They attacked the building, smashing the bust of 19th century educationist and reformer Ishwar Chandra Bandopadhyay, who was conferred with the title Vidyasagar – the ocean of education.As the BJP denied that its cadre indulged in the vandalism, the civil society was furious and the entire social media space was flooded with responses. The reason lies in Vidyasagar’s – as he is usually referred to – contribution to the making of the modern Bengali society. He was not just a formidable intellectual but reformed a community in 19th century, much like Periyar Erode Venkatappa Ramasamy or Bhimrao Ramji Ambedkar.Bengalis mostly remember him for his pioneering work, Barna Parichay, a book to introduce Bengali to beginners. But the range of his work is vast — from developing the language, especially its modern prose form, to sustained campaigns against various social menaces.last_img read more

Cyclone ‘Bulbul’: West Bengal govt pegs losses at ₹23,811 cr

first_imgWest Bengal has incurred a loss of ₹23,811 crore in the devastations caused by cyclone Bulbul that has affected around 35 lakh people in three districts, said a report the state government submitted to the visiting central team said on Saturday. The report was handed over to the members of the central team during a meeting with state Chief Secretary Rajiva Sinha at the secretariat and a separate report would be sent to the Centre. Members of the team called on the State government officials on Saturday, a day after they visited the cyclone-hit areas in North & South 24 Parganas and Purba Midnapore districts to assess the extent of damage caused by the storm.“The state has incurred a total loss of ₹23,811 crore in the three districts ravaged by cyclone Bulbul where over 35 lakhs of people have been directly affected. A total of 5,17,535 houses were damaged in the cyclone,” a senior official said, quoting from the report. Altogether 14,89,924 hectare of agricultural land have been damaged, it said adding that the power department has incurred a loss of ₹597 crore. As many as 4,35,000 tarpaulin and 6.2 lakh water pouches have been distributed by the state Public Health Engineering department, the report said.“Reports on losses incurred in North and South 24 Parganas and East Medinipur districts due to the storm and requirement in those areas were handed over to the central team. We would submit a separate report to the Centre,” the IAS officer said. The central team have made ground visits, conducted aerial surveys of the affected areas and met officials of the three affected officials.“We visited the areas affected by the cyclone to assess the extent of devastation. We have spoken to all the people concerned,” a member of the central team said.“We have taken note of what we have gathered from our meetings in these districts. We will now submit a report to the central government,” he said. The team members included joint secretary of Ministry of Home Affairs K.B. Singh, assistant director of department of expenditure under the Union finance ministry Sumit Agarwal, director of department of agriculture Narendra Kumar and deputy director of Union Power Ministry O.P. Suman. Cyclone Bulbul had made landfall late on November 9 between Sagar Islands in West Bengal and Khepupara in Bangladesh. Altogether 14 people, including fishermen of a capsized trawler, died in the calamity. West Bengal Chief Minister Mamata Banerjee had earlier welcomed the visit of the team to the cyclone-hit areas. After conducting an aerial survey of the cyclone-hit areas, she had said on Wednesday that the loss incurred by the state due to the catastrophe might go up to ₹50,000 crore.last_img read more

a month agoKeane and Carragher clash over Liverpool’s title failure

first_imgKeane and Carragher clash over Liverpool’s title failureby Paul Vegasa month agoSend to a friendShare the loveManchester United legend Roy Keane has enjoyed a dig at Jamie Carragher over Liverpool’s title failure.Keane and Carragher were both in the Sky Sports studio analysing Manchester United’s latest defeat to West Ham in the Premier League. “I was in this position at Liverpool where you are trying to catch teams,” he said.”Sometimes you just need that two or three players who can transform them. I think of Luis Suarez coming to Liverpool.”For three or four years we were finishing sixth and seventh, where United are and then almost won the title.”Sometimes that one player can make all the difference.”But Keane hit back with his own response and suggested finishing runners-up would never be enough for United.”Jamie, you said almost winning the title. You didn’t win a title. You are talking about Manchester United here,” Keane said.Carragher responded by saying it would help United ‘bridge the gap’ but Keane snapped back: “But Liverpool are still trying to bridge that gap.” About the authorPaul VegasShare the loveHave your saylast_img read more

The Warriors Odds Of Going 739

As things stand coming out of the All-Star break, the Warriors will probably catch Michael Jordan’s 1995-96 Bulls, which own the record of 72 wins, and are a little better than a coin flip to pass them.Last time we checked in on Golden State’s run to 73 was back in December, when the model gave the Warriors a 54 percent chance of getting at least 72 wins and a 44.1 percent chance of at least 73. A little more than two months later, the Warriors are 48-4 and those chances are 69.8 percent to hit 72 and an even 54 percent to reach 73. From where we sit, at least, the Warriors now appear likely to break the ’96 Bulls’ record. WINSSIMSCHANCE OF EXACTLY THIS MANY WINSCHANCE OF AT LEAST THIS MANY WINS 57880.299.9 593940.899.3 64530.199.9 72785715.769.8 68631712.631.2 591<0.1%100.0% 7112182.43.3 7028075.68.9 676341.398.9 6223724.794.0 64502210.082.2 611<0.1>99.9 75575411.520.9 582030.499.7 The Warriors are shooting 46.3 percent from three on “wide open” (defender more than 6 feet away) threes, best in the league. They also lead the league in “open” threes at 41 percent and “tight” coverage threes at 37.3 percent. They do fall to fourth in “very tight” threes (36.1 percent) but have taken only 36 of those all season. Curry’s 646 3-point attempts last season were more than those Miller and Bird seasons combined — and he’s on pace to demolish that number this year. 6321<0.1>99.9 7632076.49.3 782430.50.5 50,000 CARM-Elo simulations of the Spurs’ season with data through Feb. 18Before Thursday night’s loss, the Spurs’ chance for 70 wins was 19.4 percent. With the loss, it fell to 8.9 — still absurdly high, but well back of the Warriors.Andrew Flowers and Jay Boice contributed research. 723790.80.9 According to nbaminer.com, Curry has scored 10 straight points for his team 10 times, the most in the league (James Harden is second with nine); he’s scored 15 straight team points three times (Harden is second again, two) and 20 straight once (only Paul George has also done that this season). Curry has scored five straight unanswered points 55 times (Harden is second with 47, followed by George and Klay Thompson at 30).2Reggie Jackson is the only player to score 15 unanswered points this season. Only three players have done it since the 1996-7 season — Jackson this year, Jamal Crawford in 2013-14 and Brandon Jennings in 2012-13.Probably the most alarming thing about the Warriors this season is how thoroughly they are outpacing the Spurs, another omega-level team stalking around the league. Also according to nbaminer.com, the Warriors’ average first-quarter margin is +6.04. The Spurs are second at +2.98. The Spurs remain ahead of the Warriors on the overall marks, +12.7 to +12.5, but this difference is more than accounted for in the fourth quarter, where the Warriors are -0.12 and the Spurs are an NBA-best +2.56. The Warriors’ average margin per overtime period is +4.0, best in the league.And here’s the same display of possible records we generated for the Warriors above, but for the Spurs. 71599612.081.7 73855917.154.0 67710514.245.4 50,000 CARM-Elo simulations of the Warriors’ season with data through Feb. 18 5511<0.1100.0 74803116.136.9 542<0.1100.0 (While we’re digging out old charts, get a load of Draymond in these.) 73680.10.1 If the Warriors completely gave up the 3-pointer and shot none of them per game from this point forward, the Timberwolves, who take the fewest threes per game, would need 50 games to catch up in attempts and 83 games to catch up in makes, pulling even right around the 137th game of the season. Steph Curry is 11 for 24 on threes from 30 feet or more, according to nbawowy.com. Six of those shots (and one of the makes) were from beyond half court, meaning he’s 10 for 18 between 30 feet and the center line. (The rest of the Warriors are 1 for 14 from 30-plus.) Consider this a reminder that Ben Morris dug into Steph’s imperious shot selection in December. 7712242.52.9 651380.399.8 625<0.1>99.9 6925855.294.9 In order to match the best 3-point-percentage season of Reggie Miller’s career (42.9 percent), Steph Curry (45.4 percent from three on 10.8 per game) would have to miss 31 straight threes; to match Larry Bird’s best (42.7 percent) he’d need to miss 34 straight; to match LeBron’s mark this season (27.4 percent) he would have to miss 354 straight 3-point shots. 66715314.359.7 Oh, here’s a scatter plot of 3-point attempts vs. 3-point percentage since the 1979-80 season, the first year of the 3-pointer: 532<0.1100.0 This foolishness: The Warriors create 70.4 points per game through assists. The rest of the league has a fairly linear progression from the bottom on up — the Lakers are the worst, at 43.2, and the figure creeps up team by team until it stops with the Hawks, in second place, at 60.3. That isn’t adjusted for tempo (the Warriors play at the second-fastest pace in the league), but the Dubs are also comfortably in first in percentage of passes that are assists, are secondary assists or lead to free throws. 6114502.996.9 WINSSIMSCHANCE OF EXACTLY THIS MANY WINSCHANCE OF AT LEAST THIS MANY WINS 6335447.189.3 65622812.572.1 608091.698.5 56360.1100.0 7040088.089.8 Our colleagues at ESPN Stats & Info once again have a less optimistic outlook, today giving the Warriors a 37 percent chance of hitting 73 or more wins. The explanation for the difference in the two models is the same as it was in December, when we were also more bullish than our colleagues: We devised a different rating system, called CARM-Elo, which allows good (or bad) runs of play in the simulations to inform a team’s simulated strength through the rest of the simulated season. Basically, this means that it allows for extreme performance to be reflected in the results, and the Warriors are certainly extreme.Still, all of the back-and-forth over exactly how good the Warriors are is more than a little backward. Any serious debate over whether Golden State is an all-time team dried up months ago; all that’s left now is the dreary accounting of decimal points next to the team’s name. Screw that. NBA nerds slapfighting over some grandiose meaning of the Warriors is boring — it’s the spectacle that matters, the crossovers and no-looks and nonsense transition threes, and how those feats of skill translate to the stat sheet. That in mind, here’s a bunch of Warriors facts aimed at appreciating the wild mess they’re accomplishing this season, rather than simply measuring it.The Warriors would have to miss their next 545 3-pointers to bring their team mark of 42.4 percent down to the level of the league-worst Lakers, at 31.5 percent. 6813682.797.7 663140.699.6 521<0.1%100.0% 601<0.1>99.9 6947919.618.5 Remember that two-month stretch in the summer of 2009 when Steph Curry might have gone to the Knicks, before Donnie Walsh and Mike D’Antoni went around telling anyone who would stand still long enough to hear it exactly why Curry would be a superstar? And remember how disappointing it was, then, when Curry landed on a Warriors team that didn’t use him at all in the way fans dreamed he might be used by the Pringles ‘stache? Well, Curry found his way into the seven-seconds-or-less offense anyway. By NBA.com’s count (which can lag a game or two behind), the Warriors have taken 299 threes in the first seven seconds of the shot clock and made 48.5 percent of them. The next closest by percentage is Indiana, at 42.5 on 167 attempts; Houston, first in attempts with 301 (in four more games than Golden State) has made 38.9 percent of its own; and the Thunder have found a way to make just 31.6 percent on 171 attempts. On all field goals in the seven-seconds-or-less window,1NBA.com doesn’t have free-throw data for these, for some reason. the Warriors have a 68 percent effective field-goal percentage — the next closest is the Cavs, at 63.4 percent. The Knicks, meanwhile, are last in the league at 51.4 percent. read more

Modern Times Group MTG has unveiled a new financ

first_imgModern Times Group (MTG) has unveiled a new financial reporting structure as part of its ongoing transformation from a broadcaster into a ‘digital entertainment company’.The Nordic pay and free TV operator will now operate through four reporting segments: Nordic Entertainment; International Entertainment; Studios; and MTGx Ventures.MTG reorganised the management of its MTGx unit late last year, unifying its Play and Viaplay services under viaplay CEO Jonas Karlén and naming Arnd Benninghoff as MTG executive vice-president and CEO of MTGx Ventures, reporting to Mathias Hermansson, the unit’s new executive chairman. Those management changes also saw the departure of Rikard Steiber, MTG’s executive vice-president and chief digital officer.“The transformation of the Group is all about driving and shaping the fast moving changes in consumer behaviour and the video entertainment industry. This disclosure structure reflects the way in which our business is now organised and managed, as well as the way in which we expect the business to develop,” said Jørgen Madsen Lindemann, MTG’s president and CEO.“We have common revenue streams and cost bases in each of these segments, and the new structure allows us to better share investments such as content and technology across multiple platforms.”last_img read more

STAR PREVIEW Chelsea v Man U

first_img[dropcap]T[/dropcap]wo matches today and who would have thought that Bournemouth v Arsenal (1.30pm) would have much more interest in terms of the title race than Chelsea v Man U (4pm).But, as the league table shows, that’s exactly where we are at with Leicester the new Premier League favourites after their heroics at the Etihad yesterday where Man City were woeful. And that’s certainly not taking anything away from Leicester who continue to play entertaining football and make the most of their chances.Louis van Gaal will be looking over his shoulder today, not at Chelsea, but at their former boss Jose Mourinho who continues to linger in the shadows.The Portuguese has already been linked with Man U and latest reports are that communications have begun between the two parties. Mourinho has teased the situation further this morning by saying “But for sure, I will be back soon.”In terms of the match – as our ten year stats show – it’s usually close and low scoring apart from a bonkers Capital One match in 2012 that finished 5-4 to Chelsea. Today’s reverse fixture finished 0-0 at Old Trafford in December.Eden Hazard is expected to return to Chelsea’s starting XI but Pedro is doubtful. Loic Remy and Radamel Falcao are injured and recent signings Alexandre Pato and Matt Miazga both lack match fitness.Man U are still without the services of Marcos Rojo, Bastian Schweinsteiger, Antonio Valencia, Phil Jones and Luke Shaw.Chelsea v Man UtdPremier League16:00 Sky Sports 1 / Sky Sports 1 HDHEAD TO HEAD RECORD(Maximum 10 matches)Dec 2015 PREMIER Man Utd 0-0 ChelseaApr 2015 PREMIER Chelsea 1-0 Man UtdOct 2014 PREMIER Man Utd 1-1 ChelseaJan 2014 PREMIER Chelsea 3-1 Man UtdAug 2013 PREMIER Man Utd 0-0 ChelseaMay 2013 PREMIER Man Utd 0-1 ChelseaApr 2013 FA CUP Chelsea 1-0 Man UtdMar 2013 FA CUP Man Utd 2-2 ChelseaOct 2012 CAPITAL ONE CUP Chelsea 5-4 Man UtdOct 2012 PREMIER Chelsea 2-3 Man UtdChelsea have become draw specialists – their last three Premier League home games have finished all-square and whilst another draw is a tempter I feel with the return of Hazard this could make the difference and am taking Chelsea to grab all three points.This will condemn Manchester United to their worst points tally EVER in the Premier League at this stage of the season. It might just prompt a certain some-ONE to emerge from the shadows.RECOMMENDED BETS (scale of 1-50 points)BACK CHELSEA for 8 points at around 23/20 with Star SportsRETURN SINCE START OF WORLD CUP: PROFIT 16.69 POINTSWhat’s your view? CALL STAR SPORTS 08000 521 321last_img read more

STAR PREVIEW Chelsea v Derby County

first_imgPROFIT/LOSS SINCE JAN 1 2017: PROFIT 177.97 points(not including Premier League ante-post) Both Maurizio Sarri and Frank Lampard had huge challenges to go with their big managerial posts this season, but both head into November having made an excellent start as Chelsea and Derby clash ahead of their Carabao Cup clash tonight.Sarri’s Chelsea side have gone unbeaten in all competitions so far, keeping pace with the leaders in the Premier League and winning all three of their Europa League games. One of their most impressive performances came in the EFL Cup, when they won 2-1 at Liverpool thanks to the magic of Eden Hazard. Hazard will miss out tonight but the Blues – as evidenced by their Europa League performances – have a strong squad to choose from.Maurizio Sarri may need to drop Willian after starting the past nine games in all competitions, along with Pedro after his stomach ache on Saturday, Emerson and Fabregas are still likely to start in midfield whilst Reuben-Loftus Cheek – fresh from a hat-trick against BATE – will take his place in the starting XI.Frank Lampard’s Derby have really hit form since a rocky start, and the former Chelsea man will be expecting a special welcome following his exploits there. Derby are one of several clubs involved in the Championship title race and they dominated their encounter with Middlesbrough over the weekend, with a staggering 80% possession in the first 20 minutes. That was five games unbeaten and, in this competition, they managed to beat none other than Manchester United in the last round too, winning on penalties after a 2-2 draw in normal time.The hosts needed a 95th-minute header from substitute Marouane Fellaini to send the match to penalties and Derby would have been entirely deserving of going through in 90 minutes. Mason Mount has been given permission to play against his parent club whilst Fikayo Tomori is also available, and Derby will line up with a strong team.That should be enough to put anyone off trying to squeeze value out of Chelsea at very short prices on any of the handicap lines, or indeed at around 1/4 on the match odds.Chelsea v DerbyCarabao Cup, 19:45Live on Sky SportsHEAD TO HEAD RECORD(Maximum 10 matches)DEC 2014 CAPITAL ONE CUP Derby 1-3 ChelseaJAN 2014 FA CUP Derby 0-2 ChelseaMAR 2008 PREMIER LEAGUE Chelsea 6-1 DerbyNOV 2007 PREMIER LEAGUE Derby 0-2 ChelseaMAR 2002 PREMIERSHIP Chelsea 2-1 DerbyOCT 2001 PREMIERSHIP Derby 1-1 ChelseaAPR 2001 PREMIERSHIP Derby 0-4 ChelseaDEC 2000 PREMIERSHIP Derby 4-1 DerbyMAY 2000 PREMIERSHIP Chelsea 4-0 DerbyOCT 1999 PREMIERSHIP Derby 3-1 ChelseaMAY 1999 PREMIERSHIP Chelsea 2-1 DerbyDEC 1998 PREMIERSHIP Derby 2-2 ChelseaThis could also be a game with plenty of goals. Chelsea (31) and Derby (30) have combined to score 61 goals in all competitions this season. That makes the 13/10 on Over 3.5 of interest whilst the 23/20 on Derby with a two-goal start is also interesting. This looks a match to be enjoyed, and perhaps the best bet might be to aim high and go for Over 3.5 goals.RECOMMENDED BETS (scale of 1-100 points)BACK OVER 3.5 GOALS 5 points at 13/10 with starsports.betlast_img read more

Here Are the Best Black Friday Tech Deals

first_img Once you’ve had your fill of food, retailers are ready and waiting for you to do some turkey-fueled shopping. Take a look at some of the tech deals that you can jump on next weekend.Related: Holiday 2018 Spending Could Reach $1 TrillionAmazonAn Echo Spot for $89.99The new Echo Show for $179.99A Sony RX100 V camera for $892A Samsung Galaxy S9 64GB phone for $644.35WalmartA PS4 console with the new Spiderman game included for $199A Samsung 11.6-inch Chromebook 3 for $99.99A Samsung 50 inch Class 4K (2160P) UHD Smart LED TV for $327.99A Google Home Hub for $149Best BuyAn LG 60 inch Class LED UK6090 Series 2160p Smart 4K UHD TV with HDR for $549.99A Dell Inspiron 2-in-1 13.3 inch Touch-Screen Laptop for $699.99A 64GB Apple 10.5-Inch iPad Pro with Wi-Fi for $649.99AppleA refurbished HomePod for $299Office DepotAn HP 15-db0051od Laptop for $399An Epson WorkForce Pro WF-4740 Wireless All-In-One Printer, Copier, Scanner, Fax for $199.99A Dell 27 inch HD LCD Monitor for $119.99Logitech Z150 2-Piece Speakers for $14.99StaplesA VARO Portable WiFi + Bluetooth Multi-Room Speaker for $19.99A Seagate STDR5000102 5TB USB 3.0 Back Up Plus Portable Drive for $199.99A NETGEAR Arlo Smart Home Security Camera System for $119.99 1 min read Staff Writer. Covers leadership, media, technology and culture. Add to Queue Stock up on some new gadgets at a discount. Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals November 15, 2018 Entrepreneur Staffcenter_img Black Friday –shares Here Are the Best Black Friday Tech Deals Image credit: mar1koff | Getty Images Next Article Nina Zipkin Register Now »last_img read more

6 Startup Events and News to Watch This Week

first_img Add to Queue 3 min read October 7, 2013 Austin Startup Week kicks off with a battle of the bands, the Shutdown threatens to thwart D.C.-area businesses, great minds connect at the Inc. 500|5000 awards, students party hard at College Fest… This week’s notable news and startup events for entrepreneurs:1. Austin Startup Week: Kick off the Austin Startup Week with a battle of the bands competition hosted by the Austin Technology Council on Oc. 7. For the rest of the time, discussions dubbed “Co-Founders Wanted” and “Intro to the Austin Startup Scene,” among others, offer to keep you in the know and networked up the wazoo. (Austin, Texas, Oct. 7 – 11)2. Shutdown continues: The U.S. federal government shutdown heads into its second week. Small businesses continue to feel the burn. (Oct. 1 – present) Surveys sink: And if last week was any indication, government surveys, upon which many business owners have come to rely for a gauge on the U.S. economy, will also be delayed. Last week, two surveys on construction spending and manufactured goods and the monthly jobs report were delayed. This week, four more surveys will get sidetracked. Private companies shelve workers too: Though not a federal agency, Lockheed Martin plans to furlough about 3,000 employees this week due to the government shutdown. Various other defense contractors including United Technologies also said they’d furlough workers if the shutdown continued.3. Create a power partnership: Join the Impact HUB for a free introductory workshop, the first in a four-part series, aimed at helping you build “a more effective and satisfying” business partnership. (San Francisco, Oct. 8)4. Get down to business at Inc. 500|5000: Check out the Inc. 500|5000 conference and awards ceremony where the “brightest, most successful” business minds come together to celebrate achievements in private enterprise. This three-day event also features high-level keynote speakers and networking opportunities. (Washington D.C., Oct. 10 – 12)5. Tap the college market: Join the party or the exhibition at College Fest, which claims to be the “most attended back-to-school even in New England.” With more than 17,000 students in attendance, brands are lining up to put their products in the hands of this sought after demographic. (Boston, Mass., Oct. 12-13)6. Meet up with tech treps in NYC: Meet, mingle and make lasting relationships with some of Silicon Alley’s leading entrepreneurs at the NY Tech Meetup, for a night of live demos and networking. Aimed at promoting the NY tech scene and innovative, sustainable businesses, this event is a bargain at $10 a head. (New York, Oct. 8) The only list that measures privately-held company performance across multiple dimensions—not just revenue. Image credit: ATC Battle of the Bands –shares Apply Now » 6 Startup Events and News to Watch This Week Opinions expressed by Entrepreneur contributors are their own. 2019 Entrepreneur 360 List Technology Austin Startup Week kicks off with a battle of the bands, hosted
by Austin Technology Council. Next Article Brad Crescenzolast_img read more

Lipid that helps keep skin cell turnover on track may aid in

first_img Source:https://www.augusta.edu/mcg/ Reviewed by James Ives, M.Psych. (Editor)Nov 28 2018A lipid that helps keep skin cell turnover on track may help restore healthy turnover in psoriasis, investigators say.Topical application of the lipid phosphatidylglycerol, or PG, on a mouse model of psoriasis reduced inflammation as well as characteristic, raised skin lesions, they report in the Journal of Investigative Dermatology.They had already shown that PG has a role in both regulating the function of the major cell type in our skin called keratinocytes and suppressing skin inflammation.Now they have the first evidence that PG inhibits toll-like receptor activation by the antimicrobial peptides produced by those skin cells, says Dr. Wendy B. Bollag, cell physiologist in the Department of Physiology at the Medical College of Georgia at Augusta University.Toll-like receptors are a family of receptors that detect external invaders as well as internal damage signals then activate an immune response. Our skin is our largest organ and front line of defense, and a variety of skin cell types make antimicrobial peptides, which function like an endogenous antibiotic to help the skin protect us.The common skin condition psoriasis upsets the works by increasing both the production of skin cells and production of these antimicrobials by those cells.In some patients it may be a problematic immune system that initiates the vicious cycle of skin cells producing proteins called cytokines that call in more immune cells that make more cytokines that cause skin cells to make even more cytokines and excessively proliferate, says Bollag. In others, the antimicrobials may initiate the vicious cycle.Either way, more antimicrobials get produced which is probably beneficial since psoriasis also impairs the skin’s ability to prevent invaders.But these high levels of antimicrobials also produce an inflammatory response much like an invader’s might, resulting in the red, flaky patches that typically surface on high-touch areas like the elbows, forearms and knees and also show up on the scalp and elsewhere, says Bollag, the study’s corresponding author.Because at higher levels, the body sees these protective antimicrobial peptides as danger-associated molecular patterns, or DAMPS, which, as the name indicates, it views as signs of danger. DAMPS then activate toll-like receptors.It’s the increased and chronic level in psoriasis that heightens the awareness and response, says first author Dr. Vivek Choudhary, molecular biologist and physiologist in the MCG Department of Physiology.Once toll-like receptors get activated, the immune system makes proinflammatory cytokines that bring in T cells, which help drive the immune system attacks.”It’s actually T cells that help maintain the disease,” Bollag says, “But we are thinking that the innate immune system is sort of what initiates it,” she says of that toll-like receptor activation.In the continuing vicious cycle, all the immune action prompts the skin cells to actually make more antimicrobials in response to the perceived danger. “It’s a natural system that has kind of gone haywire,” she says.The investigators used S100A9 as their representative antimicrobial. In psoriasis, the levels of S100A9 correlate with the severity of the disease and, when treatment works, blood levels of S100A9 decrease.Related StoriesArtificial intelligence better than humans in diagnosing pigmented skin lesionsScientists discover how resistance to the chemotherapy drug 5-fluorouracil arisesHair loss could soon be a thing of the past, say researchersThey found that both in keratinocytes as well as inflammation-promoting immune cells called macrophages, PG suppressed activation of toll-like receptors by DAMPS, in this case S100A9.Next steps include finding a version of PG that can more easily permeate the skin since the larger lipid is a bit too big to easily pass through the natural barrier. Interestingly, psoriasis hinders the barrier function so PG can initially get through, but when the condition improves, PG’s access deteriorates, the investigators note.They suspect PG’s inhibition of toll-like receptors doesn’t just happen in psoriasis, but that constant fine tuning of the immune response is among its usual functions.”You want to be able to dial it up, but not go overboard,” Bollag says. “We think that may be part of the job of PG, to basically keep the immune system from going from zero to 60 in one second flat.”This is particularly important in body areas regularly exposed to the elements like the skin, lungs and gastrointestinal tract, she says. Maybe part of the problem with psoriasis is that this fine control no longer works well, she says.Inflammation in the absence of an infection is a hallmark of psoriasis. The resulting inflammation produces a “feed forward” response: Keratinocytes start to excessively proliferate and abnormally differentiate and the skin thickens.PG enables the normal differentiation of new skin cells as cells make their way up multiple layers, reach the surface and old cells slough off.PG is made from glycerin, a natural alcohol, water attractor and key component of many lipids, which helps skin look better and aids this healthy production and maturation of high-turnover skin cells. Glycerin is transported by aquaporin-3, which the MCG investigators believe is decreased in psoriasis versus healthy skin.Today there are a variety of topical treatments for psoriasis, including vitamin D analogues and glucocorticoids, but nothing that works great for all patients, Bollag says. Part of the problem likely is that psoriasis causes vary and the reality that they are mostly not understood. Systemic drugs also are given that generally suppress the immune response, which have obvious side effects like leaving patients susceptible to infection and cancer.Bollag doesn’t think PG will be a magic bullet either, but may one day be a good option for patients with mild disease or as an adjunct to other therapies.PG is also a component of surfactant, which enables the airs sacs in the lungs to properly inflate so we can breathe. It’s been shown to inhibit inflammation in the lungs induced by microorganisms and that it works there as well through toll-like receptors. Bollag notes these new findings about what happens in the skin are likely applicable to similar conditions, where this so-called “sterile inflammation” occurs in response to substances naturally found in the body.last_img read more

Researchers are developing brandnew method to cure brain tumors

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Apr 22 2019Scientists from Far Eastern Federal University (FEFU) in cooperation with colleagues from Blokhin Russian Cancer Research Center (Moscow), Switzerland, and Sweden for the first time studied proteins, which constitute WNT signaling pathway of the cancer stem cells of glioblastoma multiforme (GBM CD133+ CSCs), one of the most aggressive brain tumors. Researchers revealed a number of proteins, which are potential targets to attack during complex antitumor therapy. A related article was published in Oncology Reports.Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors that is extremely resistant to therapy. On average, patients with such diagnosis live for 15 months. Only 27% of patients live more than two years following the diagnosis. According to scientists, tumor resistance to treatment is associated with cancer stem cells, and, in particular, with the activation of WNT signaling pathways in them.WNT signaling pathways in human cells are responsible for a number of essential functions, including cell proliferation, i.e. their reproduction, and the ability to differentiate into other types of cells. Unfortunately, they can contribute to the proliferation of cancer cells.”The behavior of the stem cells of glioblastoma multiforme is an urgent spot calling for research in modern medicine. Irradiation, cytostatics, and contemporary targeted chemotherapy are almost ineffective against cancer stem cells. Our idea is to use radiation simultaneously with drugs that suppress DNA retrieval process in cancer cells, followed by aggressive chemotherapy, one of the strategic objectives of which is to attack cancer stem cells.” said Igor Bryukhovetskiy, the author of the research idea, the Director of the Department of Fundamental Medicine in the FEFU School of Biomedicine.Related StoriesHow cell-free DNA can be targeted to prevent spread of tumorsUsing machine learning algorithm to accurately diagnose breast cancerNew study to ease plight of patients with advanced cancerThe scientist emphasized that he and his colleagues for the first time have managed to study proteins that form the WNT signaling pathway and directly interact with its components in human CD133 + stem cells of glioblastoma multiforme. The researchers found out that the set of proteins (proteome) in glioblastoma stem cells differs fundamentally from the one in other types of tumor cells. Scientists have also recognized other potential targets, the massive suppression of which can lead to a significant improvement of complex antitumor therapy outcome. These important results need further refinement during new in-depth research.How to affect the glioblastoma cancer stem cells is a conundrum far from a trivial. To crack one has engaged the world best laboratories.”In our research, we proceed from the fact we have proved previously: cancer stem cells execute their full potential when building up a bloodstream of a tumor, significantly accelerating its growth rate. Suppression of WNT-signaling proteins will allow increasing the effectiveness of anti-angiogenic therapy, i.e. treatment directed against the formation of new microvessels based on the vascular network already existing in the tissue. Such therapy is an integral part of the modern protocol for the comprehensive treatment of glioblastoma. The results of our studies can be brought into clinical practice in the near future.” summed up Igor Bryukhovetsky. Source:https://www.dvfu.ru/en/last_img read more

Google braces for huge EU fine over Android

first_img‘Financial incentives’In the Android file, the European Commission has accused Google of requiring mobile manufacturers such as Samsung and Huawei to pre-install its search engine and Google Chrome browser on phones, and to set Google Search as the default, as a condition of licensing some Google apps.Google Search and Chrome are as a result pre-installed on the “significant majority” of devices sold in the EU, the commission says. Google is facing a massive fine from the EU this week for abusing its dominant market position EU Competition Commissioner Margrethe Vestager spoke by telephone with Google chief Sundar Pichai on Tuesday night to tell him about the decision in advance, a source close to the matter told AFP.Vestager is expected to announce that Google abused its dominant position in the market by making tie-ups with phone makers like South Korea’s Samsung and China’s Huawei.Two European sources told AFP the fine would be “several billion euros” without giving further details. EU rules say Google could be fined up to 10 percent of parent company Alphabet’s annual revenue, which hit $110.9 billion in 2017.”The fine is based on the length of the infraction, but also on whether antitrust authorities believe there was an intention to commit the offence, and whether they excluded competitors or not,” said another source close to the matter.The European Commission, the 28-nation EU’s executive arm, refused to comment.The long-awaited decision comes as fears of a transatlantic trade war mount due to President Donald Trump’s shock decision to impose tariffs on European steel and aluminium exports.Denmark’s Vestager has targeted a series of Silicon Valley giants in her four years as the 28-nation European Union’s antitrust chief, winning praise in Europe but angering Washington.The case against Android is the most significant of three complaints by the EU against the search titan, which has already been hit with a record-breaking 2.4-billion-euro fine in a Google shopping case.Brussels has repeatedly targeted Google over the past decade amid concerns about the Silicon Valley giant’s dominance of internet search across Europe, where it commands about 90 percent of the market. EU competition commissioner Margrethe Vestager is expected to say Google abused its dominant market position and to impose a multi- billion dollar fine on the internet giant The complaint formally lodged in April also accuses Google of preventing manufacturers from selling smartphones that run on rival operating systems based on the Android open source code.Google also gave “financial incentives” to manufacturers and mobile network operators if they pre-installed Google Search on their devices, the commission said.Vestager’s other scalps include Amazon and Apple.The EU’s biggest ever punishment targeted Apple in 2016 when it ordered the iconic maker of iPhones and iPads to pay Ireland 13 billion euros ($16 billion) in back taxes that it had avoided by a tax deal with Dublin.The EU has also taken on Facebook over privacy issues after it admitted that millions of users may have had their data hijacked by British consultancy firm Cambridge Analytica, which was working for Trump’s 2016 election campaign.The Google decision comes just one week before European Commission chief Jean-Claude Juncker is due to travel to the United States for crucial talks with Trump on the tariffs dispute and other issues.Transatlantic tensions are also high after Trump berated NATO allies over defence spending at a summit last week, over his summit with Russian leader Vladimir Putin, and over the US president’s pull-out from the Iran nuclear agreement and Paris climate deal. Explore further © 2018 AFP EU set to fine Google billions over Android: sources Citation: Google braces for huge EU fine over Android (2018, July 18) retrieved 18 July 2019 from https://phys.org/news/2018-07-google-braces-huge-eu-fine.html Google prepared Wednesday to be hit with huge EU fine for freezing out rivals of its Android mobile phone system in a ruling that could spark new tensions between Brussels and Washington. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Google employees sign protest letter over China search engine NYT

first_imgHundreds of Google employees have signed a protest letter over the company’s reported work on a censor-friendly search engine to get back into China, The New York Times said Thursday. Explore further © 2018 AFP Reports: Google won’t renew Pentagon contract to use AI The employees are demanding more transparency so they can understand the moral implications of their work, said the Times, which obtained a copy of the letter.It has been signed by 1,400 employees and is circulating on the company’s internal communications system, the newspaper said, quoting three people who are familiar with the document.The letter argues that the search engine project and Google’s apparent willingness to accept China’s censorship requirements “raise urgent moral and ethical issues.””Currently we do not have the information required to make ethically-informed decisions about our work, our projects, and our employment,” they say in the letter, according to the Times.Employee anger flared with a report earlier this month in The Intercept that Google is secretly building a search engine that will filter content banned in China and thus meet Beijing’s tough censorship rules.Google withdrew its search engine from China eight years ago due to censorship and hacking.The new project is said to be codenamed “Dragonfly.”The tech giant had already come under fire this year from thousands of employees who signed a petition against a $10-million contract with the US military, which was not renewed.With the secret project, Google employees are reportedly worried that they might unknowingly be working on technology that could help China hide information from its people.”We urgently need more transparency, a seat at the table, and a commitment to clear and open processes: Google employees need to know what we’re building,” the protest letter says, according to the Times.At a townhall gathering of employees on Thursday, Google CEO Sundar Pichai said the firm was committed to transparency, and that while it was “exploring many options”, it was “not close to launching a search product in China,” the Financial Times reported, citing a person present at the meeting.center_img Google employees are reportedly concerned about a secret censor-friendly search engine project for China Citation: Google employees sign protest letter over China search engine: NYT (2018, August 17) retrieved 18 July 2019 from https://phys.org/news/2018-08-google-workers-protest-censored-china.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Fantastically Preserved Viking Boat Grave and Skeletons Unearthed in Sweden

first_img Photos: Vikings Accessorized with Tiny Metal Dragons Fierce Fighters: 7 Secrets of Viking Seamen Archaeologists recently unearthed two Viking burial boats in Uppsala, Sweden — one of which was exceptionally preserved and held the remains of a dog, a man and a horse. The Vikings sent a handful of their powerful elites to the afterlife in boats laden with sacrificed animals, weapons and treasure; the funeral practice dates back to the Iron Age (A.D. 550 to 800) but was used throughout the Viking age (A.D. 800 to 1050), according to a statement. These richly appointed graves have been discovered across Scandinavia. For example, archaeologists had previously found one such burial boat in Norway that had evidence of human remains and one in western Scotland that contained a slew of burial items such as an ax, a shield boss, a ringed pin, a hammer and tongs. The elites who were given such elaborate send-offs were also often buried with animals, such as stallions.Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65892-viking-burial-boats-discovered-sweden.html?jwsource=cl已复制直播00:0000:3500:35  These burial boats were typically built with overlapping wooden planks (called “clinker built”) and had symmetrical ends, a true keel and overlapping planks joined together, said Johan Anund, the regional manager for The Archaeologists, an archeological organization working with the National Historical Museums in Sweden. Archaeologists have also found other, simpler boat structures, such as logboats, which are like a dugout wide canoe, Anand told Live Science in an email. [Photos: A Man, a Horse and a Dog Found in Viking Boat Burials] The remains of the dog and the horse were nestled in the bow of the well-preserved boat, while the remains of the man were found in the stern. “We don’t know much” about the man yet, Anund said. But analysis of the skeleton will reveal how old he was, how tall he was and if he had any injuries or diseases. Anund’s group may even be able to figure out where the man grew up and where he lived for most of his life, Anund said. As for the animals buried with him, they could have been sacrificed to help the dead person on the “other side” but could also be there to show the man’s status and rank, Anund said. It’s common to find horses and dogs in such burials, but also big birds like falcons. Archaeologists also found other items on the boat such as a sword, spear, shield, an ornate comb, and leftover wood and iron nails that were likely used in its construction. The other boat was badly damaged, probably because a 16th-century medieval cellar was built right on top of it, according to the statement. Some human and animal bones were still preserved on the damaged ship, but they seem to have been moved around, making it difficult for archaeologists to say much about them, Anund said. Archaeologists discovered the ships, the well and the cellar after a plot of land outside Uppsala was marked off to become a new building for the vicarage of Gamla Uppsala parish. They excavated the boats last month and some of the finds will go on display at Gamla Uppsala museum and the Swedish History Museum in Stockholm. Live Science Editor-in-Chief Jeanna Bryner contributed to this story. Editor’s Note: This article was updated to correct the fact that “clinker” boats meant the boats were made of overlapping wooden planks. Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoLivestlyThe List Of Dog Breeds To Avoid At All CostsLivestlyUndoArticles VallyDad Cuts Daughter’s Hair Off For Getting Birthday Highlights, Then Mom Does The UnthinkableArticles VallyUndo Photos: 10th-Century Viking Tomb Unearthed in Denmarklast_img read more