Canal Group has acquired AlternaTV the platform

first_imgCanal+ Group has acquired Alterna’TV, the platform set up by Eutelsat Americas to distribute Latin American channels overseas, notably in North America.Aterna’TV channels are currently received by over six million subscribers in the Americas via cable and internet TV. Along with the acquisition, which was carried out via its Thema channel distribution subsidiary, Canal+ has signed a long-term capacity agreement with Eutelsat to distribute the platform via the Eutelsat 113 West A and Eutelsat 117 West A satellites.Canal+ said the acquisition aligned with its ambition to grow its position in North America, where Thema set up a local office in 2013. Thema will create a new integrated business unit that will combine its existing activities in the region with Alterna’TV.“The acquisition of Alterna’TV marks a new step in our partnership with Eutelsat with whom we have been working since our creation. It will allow us to scale up our presence in North and Latin America and will reinforce our team and the portfolio of channels we offer pay-TV operators in these markets. It will complement the platform we already operate in Canada with Terra Terra – that notably distributes Planète+ in Canada and became part of Thema in January 2016 – to create Thema America which aims to become a privileged partner of operators, replicating our success with our European model that draws on an innovative editorial and commercial approach,” said Thema CEO, François Thiellet.Patricio Northland, CEO of Eutelsat Americas, a subsidiary of Eutelsat, added: “Our relationship with THEMA and Canal+ enters a new phase with the signature of this agreement. We plan to continue to support the growth of Alterna’TV in the Americas through our fleet of high-power satellites and unique local infrastructure. I take this opportunity to thank the Alterna’TV teams for their significant contribution to its success over the years.”last_img read more

STARTERS ORDERS Saturday

first_img[dropcap]W[/dropcap]elcome to Starters Orders. Our daily midday update from the trading room at Star Sports with our key market movers for the day across all sports.Saturday 27 JuneRACING1.45 NewmarketComicas 8/1 > 9/23.00 CurraghFinal Frontier 11/2 > 100/303.45 NewcastleClever Cookie 9/1 > 11/24.45 CurraghShepherd’s Purse 9/1 > 11/27.40 DoncasterBaroot 14/1 > 6/1FOOTBALLUEFA Under-21 Championship Semi-Final5pm BT SPORT5/2 Portugal U21 6/5 Germany U21 11/5 DRAWUEFA Under-21 Championship Semi-Final8pm BT SPORT6/5 Denmark U21 23/10 Sweden U21 9/4 DRAWFIFA Women’s World Cup 2015 Quarter-Final12:30am (Sat) BBC 112/5 England Women 13/10 Canada Women 2/1 DRAW(All prices subject to fluctuation) What’s your view?CALL STAR SPORTS ON 08000 521 321last_img

Lipid that helps keep skin cell turnover on track may aid in

first_img Source:https://www.augusta.edu/mcg/ Reviewed by James Ives, M.Psych. (Editor)Nov 28 2018A lipid that helps keep skin cell turnover on track may help restore healthy turnover in psoriasis, investigators say.Topical application of the lipid phosphatidylglycerol, or PG, on a mouse model of psoriasis reduced inflammation as well as characteristic, raised skin lesions, they report in the Journal of Investigative Dermatology.They had already shown that PG has a role in both regulating the function of the major cell type in our skin called keratinocytes and suppressing skin inflammation.Now they have the first evidence that PG inhibits toll-like receptor activation by the antimicrobial peptides produced by those skin cells, says Dr. Wendy B. Bollag, cell physiologist in the Department of Physiology at the Medical College of Georgia at Augusta University.Toll-like receptors are a family of receptors that detect external invaders as well as internal damage signals then activate an immune response. Our skin is our largest organ and front line of defense, and a variety of skin cell types make antimicrobial peptides, which function like an endogenous antibiotic to help the skin protect us.The common skin condition psoriasis upsets the works by increasing both the production of skin cells and production of these antimicrobials by those cells.In some patients it may be a problematic immune system that initiates the vicious cycle of skin cells producing proteins called cytokines that call in more immune cells that make more cytokines that cause skin cells to make even more cytokines and excessively proliferate, says Bollag. In others, the antimicrobials may initiate the vicious cycle.Either way, more antimicrobials get produced which is probably beneficial since psoriasis also impairs the skin’s ability to prevent invaders.But these high levels of antimicrobials also produce an inflammatory response much like an invader’s might, resulting in the red, flaky patches that typically surface on high-touch areas like the elbows, forearms and knees and also show up on the scalp and elsewhere, says Bollag, the study’s corresponding author.Because at higher levels, the body sees these protective antimicrobial peptides as danger-associated molecular patterns, or DAMPS, which, as the name indicates, it views as signs of danger. DAMPS then activate toll-like receptors.It’s the increased and chronic level in psoriasis that heightens the awareness and response, says first author Dr. Vivek Choudhary, molecular biologist and physiologist in the MCG Department of Physiology.Once toll-like receptors get activated, the immune system makes proinflammatory cytokines that bring in T cells, which help drive the immune system attacks.”It’s actually T cells that help maintain the disease,” Bollag says, “But we are thinking that the innate immune system is sort of what initiates it,” she says of that toll-like receptor activation.In the continuing vicious cycle, all the immune action prompts the skin cells to actually make more antimicrobials in response to the perceived danger. “It’s a natural system that has kind of gone haywire,” she says.The investigators used S100A9 as their representative antimicrobial. In psoriasis, the levels of S100A9 correlate with the severity of the disease and, when treatment works, blood levels of S100A9 decrease.Related StoriesArtificial intelligence better than humans in diagnosing pigmented skin lesionsScientists discover how resistance to the chemotherapy drug 5-fluorouracil arisesHair loss could soon be a thing of the past, say researchersThey found that both in keratinocytes as well as inflammation-promoting immune cells called macrophages, PG suppressed activation of toll-like receptors by DAMPS, in this case S100A9.Next steps include finding a version of PG that can more easily permeate the skin since the larger lipid is a bit too big to easily pass through the natural barrier. Interestingly, psoriasis hinders the barrier function so PG can initially get through, but when the condition improves, PG’s access deteriorates, the investigators note.They suspect PG’s inhibition of toll-like receptors doesn’t just happen in psoriasis, but that constant fine tuning of the immune response is among its usual functions.”You want to be able to dial it up, but not go overboard,” Bollag says. “We think that may be part of the job of PG, to basically keep the immune system from going from zero to 60 in one second flat.”This is particularly important in body areas regularly exposed to the elements like the skin, lungs and gastrointestinal tract, she says. Maybe part of the problem with psoriasis is that this fine control no longer works well, she says.Inflammation in the absence of an infection is a hallmark of psoriasis. The resulting inflammation produces a “feed forward” response: Keratinocytes start to excessively proliferate and abnormally differentiate and the skin thickens.PG enables the normal differentiation of new skin cells as cells make their way up multiple layers, reach the surface and old cells slough off.PG is made from glycerin, a natural alcohol, water attractor and key component of many lipids, which helps skin look better and aids this healthy production and maturation of high-turnover skin cells. Glycerin is transported by aquaporin-3, which the MCG investigators believe is decreased in psoriasis versus healthy skin.Today there are a variety of topical treatments for psoriasis, including vitamin D analogues and glucocorticoids, but nothing that works great for all patients, Bollag says. Part of the problem likely is that psoriasis causes vary and the reality that they are mostly not understood. Systemic drugs also are given that generally suppress the immune response, which have obvious side effects like leaving patients susceptible to infection and cancer.Bollag doesn’t think PG will be a magic bullet either, but may one day be a good option for patients with mild disease or as an adjunct to other therapies.PG is also a component of surfactant, which enables the airs sacs in the lungs to properly inflate so we can breathe. It’s been shown to inhibit inflammation in the lungs induced by microorganisms and that it works there as well through toll-like receptors. Bollag notes these new findings about what happens in the skin are likely applicable to similar conditions, where this so-called “sterile inflammation” occurs in response to substances naturally found in the body.last_img read more

Electronic driving systems dont always work tests show

first_img Testing finds flaws with electronic car safety systems Testing by AAA shows that electronic driver assist systems on the road today may not keep vehicles in their lanes or spot stationary objects in time to avoid a crash. © 2018 The Associated Press. All rights reserved. Explore further Citation: Electronic driving systems don’t always work, tests show (2018, November 15) retrieved 17 July 2019 from https://phys.org/news/2018-11-electronic-dont.htmlcenter_img The tests brought a warning from the auto club that drivers shouldn’t think that the systems make their vehicles self-driving, and that they should always be ready to take control.AAA also said that use of the word “pilot” by automakers in naming their systems can make some owners believe the vehicles can drive themselves.”These systems are made as an aid to driving, they are not autonomous, despite all of the hype around vehicle autonomy,” said Greg Brannon, AAA’s director of automotive engineering. “Clearly having ‘pilot’ in the name may imply a level of unaided driving, which is not correct for the current state of the development of these systems.”The test results released Thursday come after several highly publicized crashes involving Tesla vehicles that were operating on the company’s system named “Autopilot.” The National Transportation Safety Board is investigating some of the crashes, including a March fatality that involved a Model X that struck a freeway barrier near Mountain View, California.The AAA findings are the second tests showing that the systems can’t handle every situation in real-world driving, including some that are relatively common. In August, the Insurance Institute for Highway Safety released tests that showed similar problems to the AAA study.The auto club tested the systems on four vehicles that had adaptive cruise control, lane-keeping assist and automatic emergency braking. Vehicles tested included the 2018 Mercedes-Benz S Class, the 2018 Nissan Rogue, a 2017 Tesla Model S and a 2019 Volvo XC40. In addition to Tesla’s Autopilot, Volvo calls its system “Pilot Assist,” while Nissan’s is named “ProPilot Assist.”Automakers generally say they tell drivers that their cars aren’t fully self-driving and that they should always be alert and ready to intervene.AAA says the vehicles drifted out of lanes and hugged lane markers, struggling with moderate traffic, curved roads and streets with busy intersections. Three of the four would have failed to avoid a crash when the vehicle ahead of them changed lanes and a simulated stopped vehicle was ahead.”As a result we had to take evasive action,” said Brannon.Only the Tesla system brought the vehicle to a complete stop in all five track test runs, but driver intervention was needed for the others, the AAA report said.The vehicles’ owner’s manuals say that spotting a stationary vehicle after a lead vehicle changes lanes is a design limitation for the systems, Brannon said. But he said researchers expected the vehicles to see stopped vehicles and react in time.Automakers generally say that the systems are designed to supplement a human driver and they make it clear the vehicles don’t drive themselves.Nissan said its system name contains the word “assist,” showing that it’s designed to help the driver.”Mercedes-Benz has always stressed that this technology is designed to assist the driver, not to encourage customers to ignore their responsibilities as drivers,” the automaker said in a statement.Tesla says that it reminds drivers to keep their hands on the wheel. “Tesla has always been clear that Autopilot doesn’t make the car impervious to all accidents,” the company said in a statement earlier this year.A message was left Thursday seeking comment from Volvo.Brannon said that despite their shortcomings, the systems have great potential to save lives and stop crashes from happening.”Anything that can serve as a backstop to a good driver is going to enhance the safety of the system, of the driver,” he said. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. In this March 23, 2018 file photo provided by KTVU, emergency personnel work a the scene where a Tesla electric SUV crashed into a barrier on U.S. Highway 101 in Mountain View, Calif. The test results by AAA released Thursday, Nov. 15, 2018, come after several highly publicized crashes involving Tesla vehicles that were operating on the company’s system named “Autopilot.” The National Transportation Safety Board is investigating some of the crashes, including the March fatality that involved a Model X that struck a freeway barrier. (KTVU via AP, File)last_img read more

Discovery of child pornography leads to Tumblrs removal from Apples App Store

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. The platform first announced an undisclosed issue with the iOS app on Friday. Monday’s update said Tumblr uses an “industry database” to prevent the distribution of illicit content; however, the content that was discovered had not yet been included in that database.Apple requires iOS apps to have content filters to prevent the distribution of child pornography, The Verge reported.”We’re committed to helping build a safe online environment for all users, and we have a zero tolerance policy when it comes to media featuring child sexual exploitation and abuse … We immediately removed this content,” Tumblr’s statement read.Tumblr has a reputation as a platform with a permissive attitude towards adult content. The governments of Indonesia and South Korea have sparred with Tumblr over its handling of sexual content, the BBC reported.Tumblr’s statement gave no timeline for when the app may be restored to the App Store.Apple did not immediately respond to USA TODAY’s request for comment. The social networking service Tumblr announced Monday that its iOS app had been removed from Apple’s App Store after child sexual abuse content had been found on the platform during a routine audit. Citation: Discovery of child pornography leads to Tumblr’s removal from Apple’s App Store (2018, November 23) retrieved 17 July 2019 from https://phys.org/news/2018-11-discovery-child-pornography-tumblr-apple.html ©2018 USA Today Distributed by Tribune Content Agency, LLC. Explore further Indonesia blocks online-blogging site Tumblr over pornlast_img read more

You can run but you cant hide culprit for messup exposed

first_img Athletics 11 Jul 2019 They’re nuts in Naples {{category}} {{time}} {{title}} Athletics 05 Jul 2019 Kirthana hopes to spring a surprise despite not being well prepared Related News Athletics 10 Jul 2019 Khairul’s anything but speedy in his first outing this yearcenter_img Related News “If the official had done his job, this would not have happened,” said the former sprinter and coach.“I’m also puzzled that Khairul Hafiz Jantan and Jonathan Nyepa were cleared to compete in the 100m on Monday. “If their entries were confirmed, what happened to the other four? I’m really not sure what went wrong,” added Mumtaz.“I feel sorry for them as this was their first World University Games.“Kirthana and Aqil were going to use the meet to qualify for the SEA Games while Russel had sacrificed his studies and also used his own money to travel from Australia to Malaysia before flying off with the others to Italy.“I hope other sports officials will take heed of this incident. “They must attend the managers’ meeting and they must make sure the athletes’ names are confirmed.“I hope such a thing will not occur again as this could jeopardise the athletes’ careers,” said Mumtaz. KUALA LUMPUR: The Malaysian Athletics Federation (MAF) have taken a Malaysian University Sports Council (Masum) official to task for his blunder at the World University Games in Naples, Italy.Four athletes – woman triple jumper R. Kirthana, 200m sprinters Russel Nasir Taib, Mohd Aqil Yasmin and pole vaulter Iskandar Alwi – were barred from competing in their events on Wednesday because the official did not confirm their entries 24 hours before their events.MAF deputy president Mumtaz Jaafar said that they are shocked and puzzled by the incident.“It’s a terrible blow to the athletes as they had trained hard and made sacrifices for the Games,” said Mumtaz.last_img read more