Transnational Corporation of Nigeria PLC (TRANSC.ng) listed on the Nigerian Stock Exchange under the Industrial holding sector has released it’s 2017 interim results for the first quarter.For more information about Transnational Corporation of Nigeria PLC (TRANSC.ng) reports, abridged reports, interim earnings results and earnings presentations, visit the Transnational Corporation of Nigeria PLC (TRANSC.ng) company page on AfricanFinancials.Document: Transnational Corporation of Nigeria PLC (TRANSC.ng) 2017 interim results for the first quarter.Company ProfileTransnational Corporation of Nigeria Plc is a diversified conglomerate with business interests in the power generation, hospitality, agriculture and oil and gas sectors. It owns and operates Transcorp Hilton Hotel in Abuja and Transcorp Hotel in Calabar. In the agriculture sector, the company produces orange and pineapple concentrates, mango puree and orange peel oil. It also grows food crops and fodder crops. In the energy sector, the company is involved in upstream petroleum development and has interests in exploring, refining and marketing oil and gas. Other business interests include generating electric power; maritime operations and supplying products for the mining and construction sectors which includes stone, sand, lime and iron. Transnational Corporation of Nigeria Plc’s head office is in Lagos, Nigeria. Transnational Corporation of Nigeria Plc is listed on the Nigerian Stock Exchange
robert reddell Please enter your comment! Mama Mia Absolutely!! The Tourist Development Tax (TDT) should be changed. They (the politicians) always act like the tourist should pay, but then they use the TDT as a political slush fund! Demings incorrectly promotes the tourists will pay most of the new “Transportation Sales Tax”. That is a bunch of “stuff”. Do the math and see how much more Orange County residents will pay for this. This reminds me of an expression…….”the figures don’t lie, but the liars do figure”. Politician’s projections are never correct…..they say what they think we will swallow…… They expect us to drink their kool-aid.Last……..CORPORATIONS NEED TO PAY THEIR FAIR SHARE! 99% FL Corporations do not pay any state income tax. THEN THESE POLITICIANS WANT MORE MONEY FROM US! OUTRAGEOUS!! It should also be noted OC is giving $125 million for the new Universal/Comcast park. Universal/Comcast is a $27 BILLION corporation. They should pay for their own road!!! Free webinar for job seekers on best interview answers, hosted by Goodwill June 11 From the Orange County NewsroomEach week, nearly 1,000 residents move to Central Florida. This presents challenges in providing proper roads, infrastructure, mass transit, sidewalks, etc.At the 2019 State of the County, Mayor Demings announced pursuing a transportation sales tax referendum in November 2020.Orange County Mayor Jerry DemingsFor Phase I of this initiative, Mayor Demings is asking for your input by participating in upcoming community meetings and Transportation surveys. Orange County’s 1.35 million residents have unique transportation needs and priorities depending on where they reside in the County – and we want to hear from you.Over the next several months, Orange County is holding public workshops to gain input from community stakeholders, learn the priorities of residents, businesses and local leaders, and build towards a long-term solution that works for everyone.District 2 Orange County Commissioner Christine MooreFrom these community meetings, Orange County will gather feedback and develop a proposed plan to improve transportation in our community. And next week, the Town Hall meeting is in Apopka.Transportation Town Hall Meeting in District 2December 5, 2019 | 6:30 P.M. – 8 P.M. (Doors Open at 6 P.M.)Wekiva High School2501 N. Hiawassee Rd., Apopka, FL 32703Join Mayor Demings and Commissioner Christine Moore for the upcoming meeting and provide your input on transportation in Orange County.RSVP to Attend 9 COMMENTS Sally December 4, 2019 at 10:26 pm I am not voting in favor of a sales tax increase for Orange County, that is for sure! They need to quit wasting tax payer money. We will get more than enough taxes imposed, without approving it at the voter booth. That is a bunch of crap. I also just realized, when I went to pay our property tax on our home, and used a credit card to pay it, that they don’t just have a standard fee for using a credit card such as, for example, $ 1.50, or maybe $ 2.00 (as an example) NOOOOO, they charge a certain percentage as a credit card transaction fee based on the amount of your tax bill due!!!!! The lady clerk, quoted me a 2. something percent fee. I didn’t catch what the 2. something was, but I said, “you’re kidding”, and she said “NO”, and I said I thought everyone paid the same as a standard transaction fee, like maybe two dollars, for example. “No” she said. She even told me some people with high tax bills, have paid like, a hundred dollars for the credit card transaction fee. A hundred dollars, that is absolute robbery! Pure greed! Look, call me petty, say OK boomer, whatever, but I charge property insurance on my credit card and do not even have to pay a cc transaction fee……I charge our vehicle insurance on our card and don’t pay a fee. This bunch is greedy! Greedy, greedy, greedy. I know if you pay your City of Apopka utility bill, like at Amscot, or Duke Energy power bill, there is a standard credit card fee, maybe even if paying cash, but it is a small fee, the same for everyone, and is not based on the amount of your bill you owe. AS I SAID, this bunch is greedy, and this should not be allowed by a government entity, basing it on the amount of your tax bill! I feel good to get this off my chest. It is not about the about we paid, it is the principle of it all. Did I use the right “principle”…? LOL If this gets posted, it will be a miracle, as my internet service has been really crappy at night, or maybe I will post ten times, just trying to get it to post, as the service keeps going on and off, driving me crazy…… December 4, 2019 at 10:56 pm Mama Mia December 4, 2019 at 10:42 pm December 6, 2019 at 10:07 am TAGSDistrict 2 Orange County Commissioner Christine MooreMayor Jerry DemingsTransportation Town Hall Previous articleApopka Police Department Arrest ReportNext articleEverything Coming to Hulu in December Denise Connell RELATED ARTICLESMORE FROM AUTHOR Drive around look at all the construction of new condos, hotels, apartments, developments and strip malls the impact fees are designed to cover such road work, transportation, schools and other related projects. the property taxes on those buildings and businesses have to be huge. the purpose for tourist taxes (hotel tax) need to be changed to include roads, paths and other projects that bring people/tourist to these businesses, resorts and parks. Also ask the parks to contribute, they build new theme parks all the time….more tourist. Leave my penny on every dollar spent alone. Cut waste in your own areas of government!They speak of adding a lot more lynx buses to help, how often do we now sit behind a bus that stops every block or two, the traffic and pollution they cause is horrible. lynx should add pullovers for every bus stop so traffic can get by as the off load and load. school buses should turn off the main roads to pick up children, safer for kids, less traffic back ups, better for environment less road rage. Support conservation and fish with NEW Florida specialty license plate My husband spent the day watching the impeachment and putting up our Christmas lights. Duke Energy sent us an offer to Fix our power bill the same amount for 12 months. So we thought it over and signed up for it. They gave us the set price with all the various taxes added on, and it seems like a bargain so that is what we went for. You can drop it, at the end of 12 months if you want, or it will renew after they review your usage. All I know is burn baby burn, the Christmas lights, the heat, the bulbs, the clothes dryer, the tv, the stove and oven, whatever…….Lol. Reply Reply Mama Mia December 4, 2019 at 11:09 pm If you were unable to attend last night’s Orange County Transportation Town Hall Meeting at the Wekiva High School, you may want to attend the last town hall scheduled for Tuesday, Dec 10th in Winter Garden.Here is the link to the infohttp://www.ocfl.net/TrafficTransportation/TransportationInitiative/Meetings/tabid/4498/Default.aspx#.XeqKj_xOnIU December 6, 2019 at 12:09 pm December 5, 2019 at 6:04 pm December 6, 2019 at 8:56 am Reply Mama Mia Reply Reply Reply You have entered an incorrect email address! Please enter your email address here Reply Well, I found out what happened along Maine St. last night. After driving by there today, we saw a yellow crime scene tape around a house and car. The car apparently crashed and wrecked and landed right up against a home there. The black small car was what I would guess to be totaled. It is a miracle it didn’t go through the home. I believe a tree stopped it from going into the home, but the car is longways right against the front of the home. OMG. We had just come by there last night going to Wawa, and coming back toward our home, I saw the fire engine and ambulance, and we were not at Wawa very long, just time to put in some gas. The Anatomy of Fear robert reddell Share on Facebook Tweet on Twitter Here is Orange County trying to hike the sales tax…..but did you catch what I happened to see on tv? The City of Groveland, just gave their residents money back! Yes, their mayor, gave each of their residents, money back that they had, what the mayor said, was an overage of the the money collected from their town’s building permits! Do you know how much they got…..???……a whopping, $ 234.00 check in the mail, for each resident in the city!!!! Some of the residents were so stunned, that they got on the phone and called city hall thinking that it was some sort of a scam. The mayor assured them it was not a scam, and was for real! OMG, do you think this would ever, ever happen in Apopka……???? They said it was an overage, and the 1.4 million, could not be used for anything else, so the mayor gave it back to the residents, as an unexpected gift, here at Christmas. I am speechless. We need a mayor like that!!!! What a jolly good soul! December 6, 2019 at 9:02 am Sally Reply Please enter your name here Reply LEAVE A REPLY Cancel reply Drive around look at all the construction of new condos, hotels, apartments, developments and strip malls the impact fees are designed to cover such road work, transportation, schools and other related projects. the property taxes on those buildings and businesses have to be huge. the purpose for tourist taxes (hotel tax) need to be changed to include roads, paths and other projects that bring people/tourist to these businesses, resorts and parks. Also ask the parks to contribute, they build new theme parks all the time….more tourist. Leave my penny on every dollar spent alone. Cut waste in your own areas of government! Mama Mia Looks like Orange County could use a few lights down lonely old dark Maine St. coming from the AHS. That street is too dark entirely. We were heading to Wawa for gas, and I told my husband that Maine Street is entirely too dark, and there are always people walking around out there. We got gas, and as we headed back down Maine St. I noticed the county fire truck and ambulance along there. I don’t know what happened, but I sure hope no one got hit by a car…..just don’t know what was going on there. I appreciate the new lights the county and the city have put out, along RSR and Park Av. Very nice. Save my name, email, and website in this browser for the next time I comment.
Saudi ArabiaMiddle East – North Africa August 4, 2011 – Updated on January 20, 2016 Arab Spring and repression continue from Rabat to Manama RSF_en News News SYRIAFiras Al-Karad, a blogger who was arrested and tortured in March, was arrested again in Deraa on 31 July.The following are still detained:- Mohamed Tahan Jamal, a member of the League of Arab Writers and the Union of Journalists and a signatory of the Aleppo Appeal for the Nation. He was arrested on 20 July.- Abd Al-Majid Tamer and Mahmoud Asem Al-Mohamed, two freelance journalists working for Kurdish news websites who were arrested on 31 May.- Omar Koush, who was arrested at Damascus international airport on 1 May as he returned from a conference in Turkey.- Anas Al-Ma’arawi, a journalist and blogger and founder of the first Arab website specializing in the Android system, who was arrested in a Damascus suburb on 1 July.- Manaf Al Zeitoun, who was arrested on 25 March. There has been no news of him since his arrest.- Mohamed Nijati Tayara, a writer and member of the Human Rights League, who was arrested at a security checkpoint on 12 March and was initially accused of disseminating false information. A Homs criminal court dropped the charges after the second amnesty of 21 June. His case was then transferred to a Damascus appeal court which has yet to take a decision. His health deteriorated after he began a hunger strike with other detainees in protest against their detention and he has not had access to appropriate treatment. His is allowed to see his wife and lawyer once a week but no one else. to go further Saudi ArabiaMiddle East – North Africa While Bahrain and Saudi Arabia use mainly technical means (including satellite jamming and website blocking) to obstruct media freedom, Yemen and Syria continue to resort to violence. Blogger and reporters covering pro-democracy demonstrations have also been roughed up in Morocco.BAHRAINLualua TV, a satellite TV station launched by 15 members of the Bahraini opposition on 17 July in London, has been jammed since the first day despite changing frequency regularly. According to Eutelsat, the jamming is being orchestrated from Bahrain. Lualua TV wanted to broadcast from Bahrain but it was repeatedly denied permission. It is still managing to broadcast on the Hotbird satellite.In a 24 July press release, the head of Lualua TV said: “A lot of hard work has gone into this channel and we are extremely disappointed that we have had trouble broadcasting our message. It comes as no surprise that the source of the jamming is Bahrain. It is as we had expected. We have followed all regulations in the creation of this station and we will not allow this setback to stop us from broadcasting permanently. We are hoping that the interference has now ended, but if it returns we will just have to find other ways to reinforce our message.”SAUDI ARABIAThe Saudi authorities have been blocking access to the newspaper Al-Akhbar’s website because of its coverage of events in Bahrain, including the Saudi military intervention. Amnesty International meanwhile reported on 26 July that its website was rendered inaccessible from within Saudi Arabia after it posted comments criticised a Saudi anti-terrorism bill that aims to reduce the impact on Saudi Arabia of the uprisings in other Arab countries (http://www.dw-world.de/dw/article/9799/0,,15265803,00.html).Shelved in 2003, and revived in response to the wave of Arab revolts, the bill would allow the authorities to prosecute anyone suspected of criticising the king or the crown prince. Its deliberately vague wording would leave room for arbitrary interpretation, restricting free speech and media freedom even more in Saudi Arabia. Like many other international NGOs in recent days, Reporters Without Borders urges the Saudi authorities drop this bill, which would violate its international obligations.Regarded by Reporters Without Borders as an “Enemy of the Internet,” Saudi Arabia is currently blocking more 1,200 websites (list: http://www.albayan.ae/24-hours/2011-07-28-1.1479040) Receive email alerts Organisation News MOROCCOThe journalist Hassan Bourah was attacked in the southwestern city of Guelmim on the evening of 31 July. He was reportedly hit in the stomach and face, insulted and threatened, and his mobile phone and press card were confiscated. He said four men forced him into car and dumped outside the city, far from the demonstrations he had been covering.Khaled Nasser, 26, a blogger based in the southwestern city of Agadir, sustained a bad head injury (http://www.youtube.com/watch?v=ZXrmPDGy5Tk&feature=related) while filming a demonstration on 17 July in support of the opposition 20 February Movement for his blogs (http://www.alfotowa.blogspot.com/ http://khalidaitnasser.blogspot.com/ and http://khalidpress.ektob.com/) and for the Agapress (http://www.agapress.com/) website. He is a member of the Association of Moroccan bloggers. A Nasser support page has been created on Facebook.Mounir El-Kataoui, a reporter for the Moroccan daily Al-Watan Alan, was also attacked while photographing and filming a demonstration in Casablanca on 29 May. Despite wearing a vest with the word “Press,” he was struck hard in the face and lost consciousness and had to be taken to hospital. The police broke his camera and his glasses.Mohamed Benba, a 17-year-old blogger (http://www.mohamedbn.blogspot.com) based in Agadir, and online journalist Bachir Lamti, 28, who edits the Sahara Press website, were the victims of intimidation attempts. Benba was threatened on 10 July following a march in Agadir by the 20 February Movement. Members of the Directorate for Territorial Surveillance, an intelligence agency, went to his school to give him a warning after he posted videos of the march on YouTube. Lamti was hit and insulted by a police officer while trying to film a demonstration in Guelmim on 17 July.YEMENAttacks and threats against journalists and confiscation of independent newspapers continue to be common in Yemen.The editor of the Akhbar Aden newspaper was kidnapped on the evening of 25 July by three men who blindfolded him and drove to a remote location where they insulted him and gave him a beating. He was released at around 4 am.Two sons of Yahia Nouri, deputy editor of the newspaper Al-Mithaq and spokesperson of the General People’s Conference, were physically attacked by government militiamen on 25 July. The journalist Sofiane Faishi was attacked the same day in the Sanaa district of Habra. Employed by the government newspaper Al-Thawra and a correspondent for Akhbar Al-Youm and other local publications, Faishi was one of the first journalists to come out in support of the opposition movement.Yasser Al-Mou’alimi, a presenter on the government satellite TV station Yemeniya, escaped with just a foot injury when gunmen opened fire on his car in an apparent murder attempt as he was returning home on 21 July. Mou’alimi, who was hospitalized after the shooting, had expressed his support for the opposition protests.The security forces in the governorate of Taiz confiscated copies of the 19 July issue of the independent weekly Al-Ahali and copies of the 19 and 20 July issues of the independent Sanaa-based daily Akhbar Al-Youmi.Mahmoud Al-Hajiri, the editor of the Democratic Party’s recently-created newspaper, has been getting telephone threats.Five gunmen stormed the Sanaa headquarters of the independent weekly Al-Nada on the afternoon of 20 July looking for owner and editor Sami Ghaleb and members of its staff. Raids of this kind were carried out three days running. The newspaper stopped publishing several weeks ago and its office is closed because of security problems and the probability that its issues would be confiscated. News RSF joins Middle East and North Africa coalition to combat digital surveillance Follow the news on Saudi Arabia Saudi media silent on RSF complaint against MBS March 9, 2021 Find out more June 8, 2021 Find out more Help by sharing this information April 28, 2021 Find out more NSO Group hasn’t kept its promises on human rights, RSF and other NGOs say
TAGS Local NewsState By Digital AIM Web Support – February 4, 2021 Twitter Previous articleIn thrice-demolished village, a Mideast battle of willsNext articleWinning numbers drawn in ‘All or Nothing Day’ game Digital AIM Web Support Pinterest AUSTIN, Texas (AP) — The winning numbers in Thursday afternoon’s drawing of the Texas Lottery’s “Pick 3 Day” game were: 8-1-8, FIREBALL: 4 (eight, one, eight; FIREBALL: four) Facebook Winning numbers drawn in ‘Pick 3 Day’ game Facebook Pinterest WhatsApp Twitter WhatsApp
Community Enhancement Programme open for applications Previous articleHarps hosting Season and Website launch on WednesdayNext articleEmergency services dealing with crash on main L’kenny to Lifford Rd News Highland Facebook By News Highland – February 5, 2019 Issues of Non-Compliance have been found in almost half of nursing homes inspected by HIQA in late 2018. 56 reports have been published today, four of them relating to nursing homes in Donegal.Of those, major fire safety concerns were identified at the Lakehouse Nursing Home in Portnablagh, with management saying immediate steps were taken to address the issues.In their report, HIQA say the registered provider had not taken adequate precautions to ensure that residents were protected from the risk of fire, or ensure that adequate systems were in place.Due to the findings of this inspection, the report noted, a referral was made to the local fire authority.In its response, the nursing home said procedures had been put in place to address the issues identified.The report also identified issues with management, staff training ad maintenance of the premises.Lakehouse Report available hereAt the Harbour Lights Nursing Home at Bruckless outside Killybegs, the premises was found to be non-compliant, with management saying plans are in place to have all outstanding issues addressed by 2021.Harbour Lights report available hereAn inspection at Nazareth House in Fahan identified issues with staffing, communications and record keeping.Nazareth House report available hereMeanwhile, an inspection of Aras Uí Dhomhnaill in Milford found that some residents did not have an opportunity to participate in activities. In both instances, management say procedures have changed to address these issues.Aras Uí Dhomhnaill report available here Twitter Arranmore progress and potential flagged as population grows WhatsApp Important message for people attending LUH’s INR clinic Loganair’s new Derry – Liverpool air service takes off from CODA Facebook Pinterest Pinterest WhatsApp HIQA publishes reports on four Donegal nursing homes RELATED ARTICLESMORE FROM AUTHOR Twitter Google+ News, Sport and Obituaries on Monday May 24th Google+ Nine til Noon Show – Listen back to Monday’s Programme Homepage BannerNews
Related posts:No related photos. Comments are closed. HR-related/specific courses: MSc/PgDip Human Resource Management,which can be taken full- (12 months for the MSc and nine months for the diploma)or part-time (24 months plus three to six months for the dissertation for theMSc and 24 months for the diploma); MSc/PG Human ResourceManagement/Development, part-time (two years), leading to CIPD graduatemembership; CIPD Certificate in Training Practice (evening or afternoon basisfor 16 weeks); CIPD Certificate in Personnel Practice; CIPD Certificate inTraining Practice; CIPD Core Management. The BSc (Hons) Business Studies whereit is possible to specialise in Human Resource Management in the final year.Salford also holds short courses, in-company training and tailored corporateprogrammes. Founded: It was originally the Royal Salford Technical Institute,set-up in 1896, and became a university in 1967. College CV: Located 1.5 miles from Manchester city centre, Salford isone of the UK’s largest universities with 18,000 students, including 2,000international students from 80 countries. It is a popular university withemployers because of its record in applied courses (Salford pioneered theconcept of sandwich degrees in the 1950s). Two-thirds of its undergraduatecourses offer work placements, many of which contribute towards the finaldegree award. In the Teaching Quality Assessments by HEFCE (Higher EducationFunding Council for England) since 1996, the 15 subject areas have scored anaverage of 21 out of 24 points. The School of Management, where the HR coursestake place, draws on an international and national network of affiliates fromindustry as well as the academic world. It also designs and implementspostgraduate qualification programmes for specific companies and corporateclients include GEC Plessey, British Aerospace, Norwich Union and several NHStrusts. It is a CIPD Centre of Excellence. Entry: For the MSc courses, a good honours degree or equivalent or astipulated level of performance on the Access Certificate or Diploma. Some workexperience in HR is desirable for the MSc course leading to graduate membershipof the CIPD but is not essential. For entry requirements for CIPD professionalcourses, see website. Star HR academics: Dr John Kidger, best known for his work in thearea of international HRM; Dr Ralph Darlington, whose specialist areas includeindustrial relations. Alumni: There is an active alumni network and the associationnegotiates benefits for members. Events are held throughout the year. www.salford.ac.uk HR academy: University of SalfordOn 12 Mar 2002 in Personnel Today Previous Article Next Article
Back to overview,Home naval-today Raytheon Awarded USD 6.5 Mln Zumwalt Deal View post tag: Naval Authorities October 3, 2014 View post tag: deal View post tag: News by topic View post tag: Navy View post tag: Raytheon View post tag: 6.5% Raytheon Co., Integrated Defense Systems, Tewksbury, Massachusetts, is being awarded a $6,5 million modification to a previously awarded contract for fiscal 2015 class services engineering efforts in support of the Zumwalt Class Destroyer Program. The purpose of this modification is to provide class services engineering efforts supporting the DDG 1000 Class Mission Systems Equipment (MSE).These efforts include MSE design and analysis, engineering and life cycle supportability, architecture and design studies, concept of operations, crewing, mission and requirements analyses, interoperability, mission support services, and test & evaluation.Most of the work will be performed in Portsmouth, Rhode Island, and is expected to be completed by September 2015. Fiscal 2014 research, development, test and evaluation contract funds in the amount of $1,099,990 will be obligated at the time of award and will expire at the end of the current fiscal year. The Naval Sea Systems Command, Washington, District of Columbia, is the contracting activity.[mappress]Press Release, October 03, 2014; Image: US Navy View post tag: Mln Follow @navaltoday View post tag: USD View post tag: americas Raytheon Awarded USD 6.5 Mln Zumwalt Deal View post tag: Zumwalt Share this article
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Over the last few months, Saturday Night Live has been lampooning the Presidential election in their cold opens. With Kate McKinnon playing Hillary Clinton and Alec Baldwin playing Donald Trump, sketches have poked fun at both candidates and their campaigns.With Trump’s victory in the election last week, many fans tuned into SNL wondering what the show would do. Instead of making a joke, the show opened with McKinnon at the piano, dressed as Hillary Clinton, performing Leonard Cohen’s anthemic ballad, “Hallelujah.” With Cohen’s recent passing and Trump’s recent victory, the opening provided an emotional moment to open the episode. At the end of the song, McKinnon turned to the camera and said, “I’m not giving up, and neither should you.” You can watch the performance in the video below.
The past year has been a hopeful one in the fight against Alzheimer’s disease. New findings have brought clarity to understanding the disease’s progress; new drugs to attack it are in trials.Rudolph Tanzi, the Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation at Harvard Medical School, last month was named to Time magazine’s list of the 100 most influential people in the world for his contributions to that fight, specifically his work uncovering the disease’s genetic underpinnings. Tanzi spoke with the Gazette about the past, present, and promising future of research into Alzheimer’s disease.GAZETTE: Where are we with Alzheimer’s, medically and scientifically?TANZI: We’re a lot farther along now than we were even last year. Back in 1986, as a Harvard student in the graduate school, my doctoral study was to discover the first Alzheimer’s gene, which is the gene that makes the amyloid. [There were also] two more genes that I discovered in 1995 called the presenilins — I say “discovered” but they’re always co-discovered; you always work with others.Those three genes and a fourth gene — all discovered in the ’80s and ’90s — all lead to excessive accumulation of beta amyloid in the brain. Beta amyloid makes up the plaque. This supported the original hypothesis of a fellow named George Glenner, who back in 1984 discovered what the amyloid was made of. I used his information about that protein to find the gene.The idea is that amyloid triggers the whole rest of the disease: the tangles that form inside the nerve cells and the inflammation that also kills a lot of nerve cells. But when we put the Alzheimer’s genes into mice, they got amyloid, they got some inflammation, and eventually they got some cognitive problems. You can say it was an Alzheimer’s model, but it really wasn’t because they didn’t get the tangles.The tangles are made up of the protein tau, which creates these twisted filaments inside the nerve cells and shuts the nerve cell down. In the mouse, the amyloid wasn’t leading to the tangles.So a lot of people said, “See, the genetics may say it’s the amyloid, but the mouse models say it’s not, because the amyloid didn’t lead to the tangles. So tangles must be coming by themselves.” Then there was a big argument: What causes the disease, the amyloid or the tangles?Some of us said they both cause the disease, but it starts with the amyloid because the genetics say so. But there were two problems. Amyloid didn’t lead to tangles in mice. And, second, in clinical trial after clinical trial, targeting the amyloid failed.People said, “It’s not amyloid, the hypothesis is wrong.” I kept saying, “No, the clinical trials are failing the hypothesis, the hypothesis is not failing the trial.”Either the drugs weren’t potent enough or they were toxic. But then some pretty good therapies were used, like these immunotherapies — these antibodies — and they failed. And so we started to worry a little bit because [the drugs] were removing some amyloid but [the subjects] still weren’t getting better.Then big news came from a study in Australia, where they tracked amyloid in people’s brains — people who were unaffected and people who had the disease.What came out of that study was that amyloid accumulates in the brain 15 years before symptoms. So in these trials, you’re treating full-blown Alzheimer’s patients for amyloid, but amyloid had already accumulated, started the disease, and done its job.It’s kind of like if you have a patient who has congestive heart failure or heart attack and they go to a cardiologist who says, “Here, just take this drug that will lower your cholesterol.” It’s too late. You had to have done that 15 years before.GAZETTE: So is the model of the disease now that the amyloid accumulates, it creates or in some way triggers the tau protein, and the tau makes the disease?TANZI: Yes, that’s exactly right, and that’s the second part of the story. Now pharmaceutical companies have started treating patients very early on in the disease. Reisa Sperling at Harvard is treating patients who don’t even have the disease yet, but imaging of the brain shows they have high amyloid so they’re at high risk of getting the disease.Secondly, Biogen just came out with a study where they treated patients with mild Alzheimer’s with an antibody called BIIB037. And when they removed the amyloid with the antibody, they actually got cognitive improvement. That was a first proof of concept that if you hit amyloid early enough, you can improve the disease.The Biogen antibody approach was based on a paper we published in 2005, where we showed that there are naturally occurring antibodies in the body, auto antibodies, to fight against amyloid.Then there was the other study we had last year, Alzheimer’s in a dish. It modeled Alzheimer’s for the first time, where you get both plaque and tangles. We were able to do this in a dish by mimicking the brain with a gel-like substance. That paper rested, finally, that 30-year [amyloid vs. tangles] debate.We showed that if you use human neurons made from stem cells and you grow it in a gel that mimics the brain, that indeed amyloid causes tangles. So now there’s no doubt. And if you stop the amyloid, you stop the tangles.You combine that with the new Biogen result and that’s why I say just in the last year, we finally have new clarity.GAZETTE: So are we at a threshold in our understanding of the disease?TANZI: Absolutely, I feel like this is the most exciting single year, between the Alzheimer’s in a dish and the Biogen result, since the discovery of the last major Alzheimer’s gene in 1995. So it’s the most exciting year in 20 years.The other exciting thing is the new genetic study. I run what is called the Alzheimer’s Genome Project, funded by a local foundation that’s just amazing, called the Cure Alzheimer’s Fund. Back in 2008, Time magazine called our first Alzheimer’s Genome Project paper one of the top 10 medical breakthroughs of the year.The gene we found back then, called CD33, we now know is the main switch that determines whether there’s inflammation in the brain as a result of all this pathology — the plaque, the tangles, the dying neurons. We know from autopsies people who died cognitively intact — no dementia in their 80s — yet with brains full of plaques and tangles. You ask what protected them: They didn’t have inflammation.We’ve done whole-genome sequencing of those brains. We’re finding variance in genes that control inflammation. That protected them. So now we know which genes are controlling inflammation. We’re setting up drug screenings using the 3-D model and other models to try to stop neuroinflammation despite rampant plaque and tangle pathology and neuronal cell death. We feel if we can do that, we can probably prevent a lot of Alzheimer’s disease.So just this year, we came to the realization that genes involved in the immune system control inflammation in the brain, and seem to be the final piece of the puzzle. First you get plaque, then tangles, then that inflammation really pushes you over the slippery slope into dementia. All this says if you have a drug cocktail where you stop amyloid, you prevent the tangles, you chill out inflammation, then you’ll stop this disease.GAZETTE: How likely is it that that sort of a cocktail will be developed? Are we five, 10, 20, we-don’t-know-how-many years away?TANZI: For amyloid, you have the Biogen antibody — we’ll see what happens, they’re going right to phase 3 [clinical trials].I also have two drugs in clinical trials. One, that stops the amyloid from aggregating, is called PBT2, from Prana Biotechnology, a company I founded in my lab. That drug aims to stop the aggregation of the amyloid in the brain so it can clear out. And then we have another drug that is just getting into clinical trials that stops the amyloid from being made, that’s called GSM, which stands for gamma-secretase modulator. So one of them basically turns off the spigot, the other unclogs the drain.I think Biogen will lead the way in terms of showing how to get amyloids out, but the antibodies they’re making are very expensive. So if you want to prevent this disease in 5 to 10 million people, as the baby boomers get older, it’s going to be tough for health care to cover.What they’re doing is opening the door with proof of concept. People like us are making little white pills that do the same thing. Hopefully — if we’re successful and it’s safe and it works — it will become what I would consider the statin for Alzheimer’s. I envision a day when you’re 40 years old, you get your brain imaged, if your amyloid looks like it’s too high for your age, then you start taking a drug that brings your amyloid back down.The second part is the tangles. What if you’ve already made some tangles? The problem is that the tangles spread through the brain. A dying neuron can spit out a tangle, which travels to a healthy neuron and causes a new tangle. In this scenario, it’s like amyloid is the match that lights the fire, but the tangle is the fire that spreads through the brain. And inflammation would be fanning the flames.A company called C2N based at WashU [Washington University, in St. Louis] just licensed to the pharmaceutical company AbbVie an antibody that stops the tangles from spreading. That is aimed for clinical trials over the next year or so. There you’re hitting the tangles.For the third part, inflammation, we just learned what the key genes are for neuroinflammation: CD33, and another gene called TREM2. Those are the main targets for stopping inflammation and those drug programs are just starting.In terms of a timeline, I think we’ll have drugs to stop amyloid that can be used for prevention in the next five to 10 years. And I think the amyloid antibody could also be in the next five to 10 years. The inflammation drugs, we could get lucky because we know exactly what we need to do, we need to stop this gene, CD33. So I think that’s maybe 10 to 15 years out.GAZETTE: So if you have Alzheimer’s now, there’s not a lot that is promising, but for prevention of future cases, we have a fairly short horizon?TANZI: For prevention, yes, it’s fairly short.If you have it now, your best bet is going to be these inflammation drugs, because the amyloid and the tangles have already done their job. Now it’s the inflammation that’s taking you out. Since we know the cells we’re targeting — they’re called microglial cells — we know what the [genetic] targets are, it could happen faster.But there’s another thing you can do even with everything going wrong. You can protect the neurons from dying even in the face of neuroinflammation. You would try to protect them against free radicals and oxidative stress, because that’s how inflammation kills.When your glial cells see a lot of dead neurons, the assumption by the glial cells is that this is an infection by a bacteria or a virus or a fungus. The inflammation allows you to shoot out free radicals like little bullets aimed at killing the infection. But in this case it’s actually killing the nerve cells, like friendly fire. So we need to chill them out; I call it a microglial chill pill. And we know that CD33 is the target, TREM2 is the target, so that can happen faster than you would think.GAZETTE: What did you think when you heard you were on Time’s list of influential people? Is it helpful to your work and to Alzheimer’s research generally?TANZI: My unit just threw me a big party, they brought in a big potluck lunch and it was great. I said, “You know, this is an honor not just for me but for Alzheimer’s research and for all of you, for everyone doing research against this disease.”I think it’s great, because it brings Alzheimer’s awareness up. Something like this acts as a vehicle to raise money, to raise support, to raise awareness. That’s what I’m most excited about.GAZETTE: How does funding for your research break down?TANZI: About 70 percent of my funding is federal and 30 percent private, with most of the latter coming from Cure Alzheimer’s Fund followed by Boston-area families.